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The map label for this gene is rppH [H]

Identifier: 78065147

GI number: 78065147

Start: 557111

End: 557758

Strand: Reverse

Name: rppH [H]

Synonym: Bcep18194_A3671

Alternate gene names: 78065147

Gene position: 557758-557111 (Counterclockwise)

Preceding gene: 78065150

Following gene: 78065146

Centisome position: 15.1

GC content: 61.11

Gene sequence:

>648_bases
ATGCTGGATCGTGAAGGCTTTCGCCCGAACGTCGGCATCATCCTCTTGAACGCGCGCAACGAGGTGTTTTGGGGCAAGCG
GCTCCGCGAGCATTCCTGGCAGTTTCCTCAAGGTGGGATCAAGTATGGCGAGACCCCCATGCAGGCGATGTACCGGGAAC
TGCACGAGGAAACGGGCCTGCATCCGGAACACGTCAAGATAATCGGCCGCACTCGCGACTGGTTGCGTTATGAGGTGCCT
GACAAGTTCATTAAACGCGAAGTACGCGGTCATTACCGCGGCCAGAAGCAGATCTGGTTCCTGCTGCGGATGGTTGGACG
CGATTGCGACATTTGCTTGCGCGCGACCGACCACCCGGAGTTCGATGCGTGGCGCTGGAACGAGTACTGGGTGCCGCTCG
ATGCGGTGATCGAGTTCAAGCGGGATGTCTATCAGTTGGCGCTGACGGAACTGTCGCGCTTCCTGCGCCGCCCGGCGCAG
CGAGCCGAGAAGCCGCGCGGGCCGCGTCTGTCGCGCTATCCGCGCGTCATTGGCGTACAGGCCCAGCAGACGCTGACGAT
TGTCGACACATCGGTAGTCTGTTCGGAGATCGAAGTGGAAGCGAGCACGCTCGACGAGATGCCGCCCCACGTGATCGTCG
GCAAATGA

Upstream 100 bases:

>100_bases
TTCAGCCGGTGTACCCCGCGCGGATTCGCTCCGTCACGGTGCGCAGCGCCCGTTATCTGTTTATAATCAAAGCAATTTTA
AAGGATTCGAAGGTGGTTGT

Downstream 100 bases:

>100_bases
CGAATCGAACTGCATGACCGGGCGCGACCTTGGTGTCGCGCCCTTTTTTTACGAGGAATGCATATTGAAAGCGATTGCTC
TCGCGCTCGCATCGATTGCC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MLDREGFRPNVGIILLNARNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLHPEHVKIIGRTRDWLRYEVP
DKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQ
RAEKPRGPRLSRYPRVIGVQAQQTLTIVDTSVVCSEIEVEASTLDEMPPHVIVGK

Sequences:

>Translated_215_residues
MLDREGFRPNVGIILLNARNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLHPEHVKIIGRTRDWLRYEVP
DKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQ
RAEKPRGPRLSRYPRVIGVQAQQTLTIVDTSVVCSEIEVEASTLDEMPPHVIVGK
>Mature_215_residues
MLDREGFRPNVGIILLNARNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLHPEHVKIIGRTRDWLRYEVP
DKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQ
RAEKPRGPRLSRYPRVIGVQAQQTLTIVDTSVVCSEIEVEASTLDEMPPHVIVGK

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=175, Percent_Identity=44.5714285714286, Blast_Score=173, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 25480; Mature: 25480

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDREGFRPNVGIILLNARNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGL
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
HPEHVKIIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPE
CHHHEEEEECCCHHHEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQRAEKPRGPRLSRYPRVIGVQ
CCCEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
AQQTLTIVDTSVVCSEIEVEASTLDEMPPHVIVGK
CCCEEEEEEHHHHHHHHHCCHHHHHCCCCEEEECC
>Mature Secondary Structure
MLDREGFRPNVGIILLNARNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGL
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
HPEHVKIIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPE
CHHHEEEEECCCHHHEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQRAEKPRGPRLSRYPRVIGVQ
CCCEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
AQQTLTIVDTSVVCSEIEVEASTLDEMPPHVIVGK
CCCEEEEEEHHHHHHHHHCCHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA