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The map label for this gene is murC

Identifier: 78065122

GI number: 78065122

Start: 531226

End: 532623

Strand: Direct

Name: murC

Synonym: Bcep18194_A3646

Alternate gene names: 78065122

Gene position: 531226-532623 (Clockwise)

Preceding gene: 78065121

Following gene: 78065123

Centisome position: 14.38

GC content: 68.67

Gene sequence:

>1398_bases
ATGAAACACATCGTCAAACACATTCATTTCGTCGGGATCGGCGGCGCGGGCATGAGCGGCATCGCCGAAGTGCTCGTCAA
CCTCGGCTACGAGGTCAGCGGCTCGGACCTGTCGCGCAACGCGGTGACGGATCGTCTCCAGGCGCTCGGCGCGCGGATCG
CGATCGGCCACGACGCGGTGAACATCGAGGGCGCGAACGCGGTGGTCGTCTCGACGGCCGTGCGCTCGGACAACCCGGAA
GTGCTGGCCGCGCGCGCGAAGCGCGTGCCGATCGTGCAGCGCGCGGTGATGCTGGCGGAGCTGATGCGTCTGAAGCAGGG
CATCGCGATCGCCGGCACGCACGGCAAGACCACGACGACGAGCCTCGTCGCGAGCGTGCTCGCGGCGGGCGGGCTCGATC
CGACCTTCGTGATCGGCGGGCGCCTGATCAGCGCCGGCGCGAACGCGCGGCTCGGCACGGGCGATTTCATCGTCGCCGAG
GCCGACGAGTCGGACGCGTCGTTCCTGAACCTGTATCCGGTGATCGAAGTCATCACGAACATCGACGCCGACCACATGGA
CACCTACGGCCACGATTTCGCGCGGCTCAAGCAGGCGTTCATCGAATTCACGCAGCGCCTGCCGTTCTACGGCAGCGCGG
TCGTGTGCGTCGACGATCCGAACGTGCGGCAGATCATCCCGTTCATCTCGAAGCCGGTCGTGCGCTACGGCCTGTCGCCG
GACGCGCAGGTGCGCGCGGAAGACATCGATGCGCGCGACGGCCGCATGCATTTCACGGTGATCCGTGACGGGCGCGCGCC
GCTCGCGGTCGTGCTGAACATGCCGGGCCTGCACAACGTGCAGAACGCGCTCGCGGCGATCGCGATCGCGACCGATCTCG
GCGTGTCGGACGACGCGATCCAGCTGGCGCTGGCGGAATTCAACGGCGTCGGCCGGCGCTTCCAGCGCTACGGCGAGGTG
CCGGCCGCGGACGGCGGCCAGTACACGCTGATCGACGACTACGGCCATCACCCGGTCGAGATGGCCGCGACGATCGCGGC
CGCGCGCGGCGCGTTCCCGGGCCGCCGCCTCGTGCTGGCGTTCCAGCCGCACCGCTACACGCGCACGCGCGACTGCTTCG
ACGATTTCGTCAACGTGCTGTCGACGGTCGACGCGCTGGTGCTGACGGAAGTCTACGCAGCCGGCGAGGCGGCGATCTCG
ACGGCCAACGGCGACGCGCTGTCGCGTGCGCTGCGCACCGTAGGGAAGGTTGACCCGGTGTTCGTCGCAACGGTCGACGA
CGTGCCGGACGCATTGGCGAAGGTCGCGCAGAACGGCGACGTGGTGATCACGATGGGCGCGGGTTCGATCGGCGGCGTGC
CGGCGAAGGTTGCGCAGCACACTCAACAGAAGGCATGA

Upstream 100 bases:

>100_bases
ACATGGCGGAACGTTCGCGCTCGCTGGCGAAGCCCGAAGCCACCGACGAAGTCGCGCGCGTGTGCGCGAAGGCGGCCGGC
GCGAACCTGGAAACACTGCA

Downstream 100 bases:

>100_bases
CATGAGCGGGATTGATCCGAAACGTTTCGGCAAGGTGGCGGTGTTGTTCGGCGGCGAGTCCTCGGAGCGCGAGGTGTCGC
TCACGTCGGGCAAGCTCGTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYEVSGSDLSRNAVTDRLQALGARIAIGHDAVNIEGANAVVVSTAVRSDNPE
VLAARAKRVPIVQRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLISAGANARLGTGDFIVAE
ADESDASFLNLYPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCVDDPNVRQIIPFISKPVVRYGLSP
DAQVRAEDIDARDGRMHFTVIRDGRAPLAVVLNMPGLHNVQNALAAIAIATDLGVSDDAIQLALAEFNGVGRRFQRYGEV
PAADGGQYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLAFQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAAIS
TANGDALSRALRTVGKVDPVFVATVDDVPDALAKVAQNGDVVITMGAGSIGGVPAKVAQHTQQKA

Sequences:

>Translated_465_residues
MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYEVSGSDLSRNAVTDRLQALGARIAIGHDAVNIEGANAVVVSTAVRSDNPE
VLAARAKRVPIVQRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLISAGANARLGTGDFIVAE
ADESDASFLNLYPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCVDDPNVRQIIPFISKPVVRYGLSP
DAQVRAEDIDARDGRMHFTVIRDGRAPLAVVLNMPGLHNVQNALAAIAIATDLGVSDDAIQLALAEFNGVGRRFQRYGEV
PAADGGQYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLAFQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAAIS
TANGDALSRALRTVGKVDPVFVATVDDVPDALAKVAQNGDVVITMGAGSIGGVPAKVAQHTQQKA
>Mature_465_residues
MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYEVSGSDLSRNAVTDRLQALGARIAIGHDAVNIEGANAVVVSTAVRSDNPE
VLAARAKRVPIVQRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLISAGANARLGTGDFIVAE
ADESDASFLNLYPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCVDDPNVRQIIPFISKPVVRYGLSP
DAQVRAEDIDARDGRMHFTVIRDGRAPLAVVLNMPGLHNVQNALAAIAIATDLGVSDDAIQLALAEFNGVGRRFQRYGEV
PAADGGQYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLAFQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAAIS
TANGDALSRALRTVGKVDPVFVATVDDVPDALAKVAQNGDVVITMGAGSIGGVPAKVAQHTQQKA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=459, Percent_Identity=53.8126361655773, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=29.7916666666667, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49085; Mature: 49085

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYEVSGSDLSRNAVTDRLQALGARIAIGHDAV
CCCHHHHEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCEEEECCCEE
NIEGANAVVVSTAVRSDNPEVLAARAKRVPIVQRAVMLAELMRLKQGIAIAGTHGKTTTT
EECCCCEEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAAGGLDPTFVIGGRLISAGANARLGTGDFIVAEADESDASFLNLYPVIEVITN
HHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCVDDPNVRQIIPFISKPVVRYGLSP
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCHHHHHCCCC
DAQVRAEDIDARDGRMHFTVIRDGRAPLAVVLNMPGLHNVQNALAAIAIATDLGVSDDAI
CCCEECCCCCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHH
QLALAEFNGVGRRFQRYGEVPAADGGQYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEE
FQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAAISTANGDALSRALRTVGKVDPV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCE
FVATVDDVPDALAKVAQNGDVVITMGAGSIGGVPAKVAQHTQQKA
EEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYEVSGSDLSRNAVTDRLQALGARIAIGHDAV
CCCHHHHEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCEEEECCCEE
NIEGANAVVVSTAVRSDNPEVLAARAKRVPIVQRAVMLAELMRLKQGIAIAGTHGKTTTT
EECCCCEEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAAGGLDPTFVIGGRLISAGANARLGTGDFIVAEADESDASFLNLYPVIEVITN
HHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCVDDPNVRQIIPFISKPVVRYGLSP
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCHHHHHCCCC
DAQVRAEDIDARDGRMHFTVIRDGRAPLAVVLNMPGLHNVQNALAAIAIATDLGVSDDAI
CCCEECCCCCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHH
QLALAEFNGVGRRFQRYGEVPAADGGQYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEE
FQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAAISTANGDALSRALRTVGKVDPV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCE
FVATVDDVPDALAKVAQNGDVVITMGAGSIGGVPAKVAQHTQQKA
EEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA