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The map label for this gene is pyrE

Identifier: 78064893

GI number: 78064893

Start: 275318

End: 276004

Strand: Reverse

Name: pyrE

Synonym: Bcep18194_A3416

Alternate gene names: 78064893

Gene position: 276004-275318 (Counterclockwise)

Preceding gene: 78064895

Following gene: 78064892

Centisome position: 7.47

GC content: 62.45

Gene sequence:

>687_bases
ATGACAGGCTACGATCGTCAGTCGATCTCGGATACGACCGCCAAAATCCTGCTCGAAGTACAGGCAGTGCACTTCAATGC
AGAAAAACCGTTCATCTTCACGTCCGGCTGGGCAAGCCCCGTCTATATCGACTGCCGCAAGCTGATTTCGTATCCGCGCG
TGCGCCGCGCGCTGATGGAAATGGCTGAAACGACGATCACGCGCGACATCGGCTTCGAGCAGATCGACGCGGTGGCGGGC
GGCGAGACGGCCGGCATCCCGTTCGCGGCCTGGATCGCGGACCGGATGATGGTGCCGATGCAGTACGTGCGCAAAAAGCC
GAAGGGTTTCGGCCGCAACGCGCAGATCGAAGGCCATCTGGAAGAAGGCTCGCGCGTGCTGCTGGTGGAAGACCTGACGA
CCGACAGCCGCAGCAAGATCAACTTCGTCAACGCGCTGCGCACCGCGGGCGCGACGGTGAACCACTGCTTCGTGCTGTTC
CACTACAACATCTTCAAGGAAAGCGTGTCGGTCCTGAAGGACATCGACGTCGACCTGCACGCGCTCGCCACGTGGTGGGA
CGTGCTGCGCGTCGCGAAGGCATCGGGCTACTTCGAGACCAAGACGCTCGACGAAGTCGAGAAATTCCTGCACGCACCGG
CCGAGTGGTCGGCGGCGCACGGCGGCGCGACGTCCCCGAAGGACTGA

Upstream 100 bases:

>100_bases
GCGATTGGCCCTCCGATCGCGCCCCGGCCCCCTGGGCAGGTTCCCCTTGCTGCGCCACCGGGCCCGCGCCCGCTCTTCGC
TCATCACCCAAGGAATGCCC

Downstream 100 bases:

>100_bases
CGCCGTGCCGGCCCGCTGGCCGGCGTCCTGGCCGAACAAGCCGCCCGCTTCATCGCGGGCGGTTTTTTTTCGCCCGCCGA
TTTTGCGTCCGTCGATCCGC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTGYDRQSISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRALMEMAETTITRDIGFEQIDAVAG
GETAGIPFAAWIADRMMVPMQYVRKKPKGFGRNAQIEGHLEEGSRVLLVEDLTTDSRSKINFVNALRTAGATVNHCFVLF
HYNIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKD

Sequences:

>Translated_228_residues
MTGYDRQSISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRALMEMAETTITRDIGFEQIDAVAG
GETAGIPFAAWIADRMMVPMQYVRKKPKGFGRNAQIEGHLEEGSRVLLVEDLTTDSRSKINFVNALRTAGATVNHCFVLF
HYNIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKD
>Mature_227_residues
TGYDRQSISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRALMEMAETTITRDIGFEQIDAVAGG
ETAGIPFAAWIADRMMVPMQYVRKKPKGFGRNAQIEGHLEEGSRVLLVEDLTTDSRSKINFVNALRTAGATVNHCFVLFH
YNIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKD

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=208, Percent_Identity=27.4038461538462, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17508631, Length=131, Percent_Identity=35.1145038167939, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17554964, Length=169, Percent_Identity=27.2189349112426, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17933654, Length=198, Percent_Identity=28.2828282828283, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25499; Mature: 25368

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYDRQSISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRALME
CCCCCCCHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAETTITRDIGFEQIDAVAGGETAGIPFAAWIADRMMVPMQYVRKKPKGFGRNAQIEGHL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
EEGSRVLLVEDLTTDSRSKINFVNALRTAGATVNHCFVLFHYNIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGYDRQSISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRALME
CCCCCCHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAETTITRDIGFEQIDAVAGGETAGIPFAAWIADRMMVPMQYVRKKPKGFGRNAQIEGHL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
EEGSRVLLVEDLTTDSRSKINFVNALRTAGATVNHCFVLFHYNIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA