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The map label for this gene is xapR [H]

Identifier: 78064739

GI number: 78064739

Start: 94750

End: 95649

Strand: Reverse

Name: xapR [H]

Synonym: Bcep18194_A3262

Alternate gene names: 78064739

Gene position: 95649-94750 (Counterclockwise)

Preceding gene: 78064741

Following gene: 78064738

Centisome position: 2.59

GC content: 70.22

Gene sequence:

>900_bases
ATGGATCTCACCCTGCTCCGTGCGTTTGCAACGGTCGCGCGCGAAGGCAACCTGACGCGCGCCGCCGTACACCTGCACCT
GACGCAGCCAGCGGTCAGCCTGCAGATCAAGCATCTGCAGGAAACGCTTGGCGTCACGCTGTTTACGCGCACGTCGCGCG
GGCTCGCGCTCACGCGCGACGGCCAGACGCTGTTGCCGCATGCGGAACGCGCGCTCGCCGCGGCCGCCGACGTGCAGCGC
GCCGCTGCTGCGCTGCGGCACGAGGTGCGCGGCCGGCTGCGGATCGGCACGATCCTCGATCCGGGTTTCCTGCGGCTCGG
CGGCTTCCTGCGCGCGCTCGTCGAAACCCATCCTCAGATCGAGACGGCGCTGCGGCACGGGATGTCGGGCTGGGTGATCG
AACAGGTGCGCACGCAGGCGCTCGACGTCGGCTACTACATCGGCCGTCCGGGCGAGGACGACCCGCTCGACGGCGCGCTG
TTCCACACCGTCACGCTCACGCATTTCCAGTACCGCGTGCTTGCGCCGGCCGGCTGGAAGGAGCGCGTGCAGCGCGCCCA
CGACTGGCGCTCGCTGGCCGCGCTGCCGTGGATCTGGACGCCGCCGGCGTCCGCGCACCACCGGCTGCTGTCCCGGCGCT
TCGCCGATGCCGGCGCGCAGCCGCTCAAGGTTGCCGAGGTCGACCAGGAGCAGTCGATGCTCGATCTCGTCAAATCGGGG
ATCGGGTTGACGCTCGCGCGCGACTCGACCGCGCTGGCCGAAGCGCACGCGCATGCGCTGACGATCGTCGAGCCCGTGAC
GGTGCCGACCGAACTGACGTTCGTGGCACTCGCCGAGCGGTGCGATGAACCGGCGATCGCGGCGGCACTGCGGCTGATAG
AAGCGCAATGGTCGATATGA

Upstream 100 bases:

>100_bases
GGCCCCGCGCGCCACGACCGATGAAGCGTACTCCGGCCGCCGGCCGCCAATCCAATGAGTTATGCTGAACTGCGTTATAA
GCTGCGCTCATATCACGACG

Downstream 100 bases:

>100_bases
GTGTCGCTGATAGCGCTACGGCTGGCCAAGCACCGGGCGTCAACGCCTGACACATCGCCGGTCGGCAACCGGCGGCCGTG
CGGGCCATCACGTGTGCATG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MDLTLLRAFATVAREGNLTRAAVHLHLTQPAVSLQIKHLQETLGVTLFTRTSRGLALTRDGQTLLPHAERALAAAADVQR
AAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVIEQVRTQALDVGYYIGRPGEDDPLDGAL
FHTVTLTHFQYRVLAPAGWKERVQRAHDWRSLAALPWIWTPPASAHHRLLSRRFADAGAQPLKVAEVDQEQSMLDLVKSG
IGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVALAERCDEPAIAAALRLIEAQWSI

Sequences:

>Translated_299_residues
MDLTLLRAFATVAREGNLTRAAVHLHLTQPAVSLQIKHLQETLGVTLFTRTSRGLALTRDGQTLLPHAERALAAAADVQR
AAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVIEQVRTQALDVGYYIGRPGEDDPLDGAL
FHTVTLTHFQYRVLAPAGWKERVQRAHDWRSLAALPWIWTPPASAHHRLLSRRFADAGAQPLKVAEVDQEQSMLDLVKSG
IGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVALAERCDEPAIAAALRLIEAQWSI
>Mature_299_residues
MDLTLLRAFATVAREGNLTRAAVHLHLTQPAVSLQIKHLQETLGVTLFTRTSRGLALTRDGQTLLPHAERALAAAADVQR
AAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVIEQVRTQALDVGYYIGRPGEDDPLDGAL
FHTVTLTHFQYRVLAPAGWKERVQRAHDWRSLAALPWIWTPPASAHHRLLSRRFADAGAQPLKVAEVDQEQSMLDLVKSG
IGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVALAERCDEPAIAAALRLIEAQWSI

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=258, Percent_Identity=28.6821705426357, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693105, Length=278, Percent_Identity=24.4604316546763, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI157672245, Length=141, Percent_Identity=34.7517730496454, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787601, Length=219, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082132, Length=161, Percent_Identity=31.6770186335404, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994962, Length=73, Percent_Identity=46.5753424657534, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790208, Length=304, Percent_Identity=25.3289473684211, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32809; Mature: 32809

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTLLRAFATVAREGNLTRAAVHLHLTQPAVSLQIKHLQETLGVTLFTRTSRGLALTRD
CCHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCEEEECC
GQTLLPHAERALAAAADVQRAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCHH
ETALRHGMSGWVIEQVRTQALDVGYYIGRPGEDDPLDGALFHTVTLTHFQYRVLAPAGWK
HHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHEEEHHEEEEEECCCCHH
ERVQRAHDWRSLAALPWIWTPPASAHHRLLSRRFADAGAQPLKVAEVDQEQSMLDLVKSG
HHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCC
IGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVALAERCDEPAIAAALRLIEAQWSI
CCEEEECCCHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLTLLRAFATVAREGNLTRAAVHLHLTQPAVSLQIKHLQETLGVTLFTRTSRGLALTRD
CCHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCEEEECC
GQTLLPHAERALAAAADVQRAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCHH
ETALRHGMSGWVIEQVRTQALDVGYYIGRPGEDDPLDGALFHTVTLTHFQYRVLAPAGWK
HHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHEEEHHEEEEEECCCCHH
ERVQRAHDWRSLAALPWIWTPPASAHHRLLSRRFADAGAQPLKVAEVDQEQSMLDLVKSG
HHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCC
IGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVALAERCDEPAIAAALRLIEAQWSI
CCEEEECCCHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]