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The map label for this gene is yciC [H]

Identifier: 78064723

GI number: 78064723

Start: 78092

End: 79405

Strand: Direct

Name: yciC [H]

Synonym: Bcep18194_A3246

Alternate gene names: 78064723

Gene position: 78092-79405 (Clockwise)

Preceding gene: 78064722

Following gene: 78064725

Centisome position: 2.11

GC content: 65.07

Gene sequence:

>1314_bases
ATGAATCCGGCAATGAACCAGCCGTTGCCCGTCACCGTGCTGTCGGGCTTCCTCGGCGCCGGCAAGACCACGCTGCTCAA
TCACATCCTCGCGAACCGCGCGGGCCTGAAGGTCGCCGTGATCGTCAACGATCTCGCGGCGGTCAACATCGATGCCTCGC
TCGTGCGCGATGCGCAGGCGCTGTCGCACGTCGAGGAACGCCTCGTCGAGATGTCGAACGGCTGCATCTGCTGCACGCTG
CGTGACGACCTGCTCGTCGAAATCCGCACGCTCGCGTCCGAAGGGCGCTTCGACGCGATCATGATCGAATCGACCGGCAT
CGCGGAGCCGATGCCGATCGCCGAAACCTTCACGTTCGTCGACGACGACGGCACGTCGCTGTCGAAAATCGCGCGGCTCG
ATACGCTCGTCACCGTGGTCGATGCGTACAACTTCCTGCGCGACTACGGCTCGGACGACGCGCTCGCGACGCGCGGCATC
GCCGCATCGGAAGAGGACGACCGCACGCTCGTCGAGCTGCTGATCGAGCAGATCGAGTTCTGCGACGTGCTGGTGATCAA
CAAGGCCGATCTCGTTGCCGCGGACGACCTCGCACGCCTGCAGCACATTCTTGCGCGACTCAATCCGCGCGCGCACCAGG
TCGTGTCGACGTTCGGCAACGTGCCGCTCGACGAAGTGCTGAACACGGGCCGCTTCGATTTCGACGAGGCCGCGAACGCA
CCGGGCTGGCTCGCGTCGCTCGATCACGATCACACGCACTGCGACGACCCGGACTGCCATGACGAACATCATGCGCACGT
GCACGGCGAAGCCGACGAATTCGGCATCGGCAATTTTGTTTACCGTGCGCGCCGGCCGTTTCATCCGGCACGACTCTGGG
CGCTGTTGCATCAGGAGTGGCCGGGCGTGCTGCGCAGCAAGGGCTTCTTCTGGCTCGCGACGCGCAACGACATCGCGGGA
TCGCTGTCGCAGGCGGGCGGCGTATGCCGGCATGGCCCGGCAGGTCTCTGGTGGGCGGCGCAGGATCGTGCGGAATGGCC
CGACGACGATGAGCTGCTCGGTGAAATCCGCGCCGAATGGCACGGCGATCTCGACGACCACAGTGTGGGCGATCGTCGGC
AGGAACTCGTGCTGATCGGCATCGCGCTCGACGCGGATGCATGGCGCGAGAAGCTCGATGCCTGCCTGCTGACCGATGCG
GAATTCGCACTCGGCGCAGCGGGATGGGATGCATTCGACGATCCGTTCCCGGCATGGGATGTCGATTCGCACGACGACGA
CGATCACGGCGACACGCAGATCGTGCACGCGTAA

Upstream 100 bases:

>100_bases
AATGCGGGCTCACGCCGCAGTTTCGCCCGTCCACGGGACGATCGCGCCCCGGAAGGGCGCCGCGGCCGCTTTTTCAATTT
TTCCGTTGGTGCATATCGCT

Downstream 100 bases:

>100_bases
CGCGTTGTAAAAACAACCGTTAAATCTTGCAAGAGGGGCGCGGACTGTGGCGAAAATGCCGCGCGCGCCCAACAAAAAAC
CCGCCGAAAGGCGGGTTTTT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNPAMNQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASLVRDAQALSHVEERLVEMSNGCICCTL
RDDLLVEIRTLASEGRFDAIMIESTGIAEPMPIAETFTFVDDDGTSLSKIARLDTLVTVVDAYNFLRDYGSDDALATRGI
AASEEDDRTLVELLIEQIEFCDVLVINKADLVAADDLARLQHILARLNPRAHQVVSTFGNVPLDEVLNTGRFDFDEAANA
PGWLASLDHDHTHCDDPDCHDEHHAHVHGEADEFGIGNFVYRARRPFHPARLWALLHQEWPGVLRSKGFFWLATRNDIAG
SLSQAGGVCRHGPAGLWWAAQDRAEWPDDDELLGEIRAEWHGDLDDHSVGDRRQELVLIGIALDADAWREKLDACLLTDA
EFALGAAGWDAFDDPFPAWDVDSHDDDDHGDTQIVHA

Sequences:

>Translated_437_residues
MNPAMNQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASLVRDAQALSHVEERLVEMSNGCICCTL
RDDLLVEIRTLASEGRFDAIMIESTGIAEPMPIAETFTFVDDDGTSLSKIARLDTLVTVVDAYNFLRDYGSDDALATRGI
AASEEDDRTLVELLIEQIEFCDVLVINKADLVAADDLARLQHILARLNPRAHQVVSTFGNVPLDEVLNTGRFDFDEAANA
PGWLASLDHDHTHCDDPDCHDEHHAHVHGEADEFGIGNFVYRARRPFHPARLWALLHQEWPGVLRSKGFFWLATRNDIAG
SLSQAGGVCRHGPAGLWWAAQDRAEWPDDDELLGEIRAEWHGDLDDHSVGDRRQELVLIGIALDADAWREKLDACLLTDA
EFALGAAGWDAFDDPFPAWDVDSHDDDDHGDTQIVHA
>Mature_437_residues
MNPAMNQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASLVRDAQALSHVEERLVEMSNGCICCTL
RDDLLVEIRTLASEGRFDAIMIESTGIAEPMPIAETFTFVDDDGTSLSKIARLDTLVTVVDAYNFLRDYGSDDALATRGI
AASEEDDRTLVELLIEQIEFCDVLVINKADLVAADDLARLQHILARLNPRAHQVVSTFGNVPLDEVLNTGRFDFDEAANA
PGWLASLDHDHTHCDDPDCHDEHHAHVHGEADEFGIGNFVYRARRPFHPARLWALLHQEWPGVLRSKGFFWLATRNDIAG
SLSQAGGVCRHGPAGLWWAAQDRAEWPDDDELLGEIRAEWHGDLDDHSVGDRRQELVLIGIALDADAWREKLDACLLTDA
EFALGAAGWDAFDDPFPAWDVDSHDDDDHGDTQIVHA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI146231952, Length=234, Percent_Identity=32.4786324786325, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI33469141, Length=234, Percent_Identity=32.0512820512821, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI126722884, Length=234, Percent_Identity=32.0512820512821, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI148727351, Length=234, Percent_Identity=32.0512820512821, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI223941779, Length=251, Percent_Identity=30.6772908366534, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI223941776, Length=219, Percent_Identity=31.9634703196347, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI119120938, Length=148, Percent_Identity=36.4864864864865, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87082430, Length=234, Percent_Identity=32.9059829059829, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788499, Length=109, Percent_Identity=37.6146788990826, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=234, Percent_Identity=28.6324786324786, Blast_Score=93, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 48075; Mature: 48075

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPAMNQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASLVRDAQA
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHHHHHH
LSHVEERLVEMSNGCICCTLRDDLLVEIRTLASEGRFDAIMIESTGIAEPMPIAETFTFV
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHEEEEE
DDDGTSLSKIARLDTLVTVVDAYNFLRDYGSDDALATRGIAASEEDDRTLVELLIEQIEF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHH
CDVLVINKADLVAADDLARLQHILARLNPRAHQVVSTFGNVPLDEVLNTGRFDFDEAANA
CCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHCCC
PGWLASLDHDHTHCDDPDCHDEHHAHVHGEADEFGIGNFVYRARRPFHPARLWALLHQEW
CCCEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHC
PGVLRSKGFFWLATRNDIAGSLSQAGGVCRHGPAGLWWAAQDRAEWPDDDELLGEIRAEW
CHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHH
HGDLDDHSVGDRRQELVLIGIALDADAWREKLDACLLTDAEFALGAAGWDAFDDPFPAWD
CCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
VDSHDDDDHGDTQIVHA
CCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MNPAMNQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASLVRDAQA
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHHHHHH
LSHVEERLVEMSNGCICCTLRDDLLVEIRTLASEGRFDAIMIESTGIAEPMPIAETFTFV
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHEEEEE
DDDGTSLSKIARLDTLVTVVDAYNFLRDYGSDDALATRGIAASEEDDRTLVELLIEQIEF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHH
CDVLVINKADLVAADDLARLQHILARLNPRAHQVVSTFGNVPLDEVLNTGRFDFDEAANA
CCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHCCC
PGWLASLDHDHTHCDDPDCHDEHHAHVHGEADEFGIGNFVYRARRPFHPARLWALLHQEW
CCCEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHC
PGVLRSKGFFWLATRNDIAGSLSQAGGVCRHGPAGLWWAAQDRAEWPDDDELLGEIRAEW
CHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHH
HGDLDDHSVGDRRQELVLIGIALDADAWREKLDACLLTDAEFALGAAGWDAFDDPFPAWD
CCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
VDSHDDDDHGDTQIVHA
CCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]