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The map label for this gene is hemC

Identifier: 161702955

GI number: 161702955

Start: 2859314

End: 2860318

Strand: Reverse

Name: hemC

Synonym: Bcep18194_A5752

Alternate gene names: 161702955

Gene position: 2860318-2859314 (Counterclockwise)

Preceding gene: 78067223

Following gene: 78067220

Centisome position: 77.43

GC content: 71.34

Gene sequence:

>1005_bases
ATGAATTCCGAGACCCCTGCGGCCGGGCCGCAACAGGCACAGCTGCCCGCGACGTTGACGATTGCTTCGCGCGAGAGCCG
CCTGGCGATGTGGCAAGCCGAACATGTGCGTGATGCGCTGCGCAAATTATATCCAGCTTGTGACGTGAACATCCTCGGGA
TGACGACGCGCGGCGACCAGATTCTCGATCGCACGCTGTCGAAGGTCGGCGGCAAGGGCCTGTTCGTGAAGGAACTGGAG
GCCGCGCTGGCCGACGGCCGCGCCGATCTCGCCGTGCATTCGCTGAAGGACGTGCCGATGGCGCTGCCCGACGGCTTCTC
GCTCGCCGCGATCATGGAGCGCGAAGACCCGCGCGATGCATTCGTGTCGAACGACTACGCGTCGCTCGACGCGCTGCCGG
CCGGCGCCGTGGTCGGCACGTCGAGCCTGCGCCGCGAGGCGATGCTGCGCTCGCGCTATCCGCACCTGGAAGTGCTGCCG
CTGCGCGGCAACCTCGATACCCGCCTGTCGAAACTCGACCGCGGCGACTACGCGGCGATCATCCTCGCGGCTGCCGGCCT
GAAGCGCCTCGGCCTCGAAACGCGGATCCGCGCGTTGCTCGACGTCGAGGCGAGCCCGCCCGCCGCAGGCCAGGGCGCGC
TCGGCATCGAGATCGCATCGCACCGCAGCGACGTCGCCGCGTGGCTCGCACCGCTGCACGACCCGCAGACCGCGCTCGCG
GTCGAGGCCGAGCGGATGGTGTCGCGCGCGCTCGGCGGCAGCTGCGAGGTGCCGCTCGCCGCGCACGCGGTGTGGCGCGC
GGGCGAACTGTACCTCACCGGCCGCGTGTCGACGACCGACGGCAAGCGTGTGCTGACGGCCGAGGAGTGCGGGGCCGTCG
TGACCGTCGCCGATGCGCTCGCGCTCGGCCGCGCCGTGTCCGACGAACTCGAGGCGCAAGGCGCGCTCGACATCGTCCAG
GCGCTGCTCGCGGGCTCGCCGCCCGCCGGCAAGGGCGACGCCTGA

Upstream 100 bases:

>100_bases
CGCGTGGCGGCAGGCCGGGCGCAGGCTCCAGGCCCGGGCGGGCAGGGGCGTGCGTGCTACCATTGTTCGATCTTCAATCC
CGTCCTTCGATGTTCCAGCA

Downstream 100 bases:

>100_bases
TGGCGGGCGGCGCGCGCGCGTTCACCGCTGTCCTGACGCGCCCGGACGGCCAGTCCGGCGCGCTTGCGTCGCAACTGGCC
GAGGCCGGTTGCGACGTGCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MNSETPAAGPQQAQLPATLTIASRESRLAMWQAEHVRDALRKLYPACDVNILGMTTRGDQILDRTLSKVGGKGLFVKELE
AALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLP
LRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLETRIRALLDVEASPPAAGQGALGIEIASHRSDVAAWLAPLHDPQTALA
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQ
ALLAGSPPAGKGDA

Sequences:

>Translated_334_residues
MNSETPAAGPQQAQLPATLTIASRESRLAMWQAEHVRDALRKLYPACDVNILGMTTRGDQILDRTLSKVGGKGLFVKELE
AALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLP
LRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLETRIRALLDVEASPPAAGQGALGIEIASHRSDVAAWLAPLHDPQTALA
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQ
ALLAGSPPAGKGDA
>Mature_334_residues
MNSETPAAGPQQAQLPATLTIASRESRLAMWQAEHVRDALRKLYPACDVNILGMTTRGDQILDRTLSKVGGKGLFVKELE
AALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLP
LRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLETRIRALLDVEASPPAAGQGALGIEIASHRSDVAAWLAPLHDPQTALA
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQ
ALLAGSPPAGKGDA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=267, Percent_Identity=47.565543071161, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI66933009, Length=267, Percent_Identity=47.565543071161, Blast_Score=241, Evalue=6e-64,
Organism=Escherichia coli, GI48994974, Length=315, Percent_Identity=53.3333333333333, Blast_Score=300, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=39.1849529780564, Blast_Score=208, Evalue=9e-55,
Organism=Drosophila melanogaster, GI20130425, Length=280, Percent_Identity=44.2857142857143, Blast_Score=207, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35113; Mature: 35113

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSETPAAGPQQAQLPATLTIASRESRLAMWQAEHVRDALRKLYPACDVNILGMTTRGDQ
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHH
ILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDA
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHH
FVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLSKLDRGDYAAI
HHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCHHHH
ILAAAGLKRLGLETRIRALLDVEASPPAAGQGALGIEIASHRSDVAAWLAPLHDPQTALA
HHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHH
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADAL
HHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCEEEEHHHCCCEEHHHHHH
ALGRAVSDELEAQGALDIVQALLAGSPPAGKGDA
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNSETPAAGPQQAQLPATLTIASRESRLAMWQAEHVRDALRKLYPACDVNILGMTTRGDQ
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHH
ILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDA
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHH
FVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLSKLDRGDYAAI
HHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCHHHH
ILAAAGLKRLGLETRIRALLDVEASPPAAGQGALGIEIASHRSDVAAWLAPLHDPQTALA
HHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHH
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADAL
HHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCEEEEHHHCCCEEHHHHHH
ALGRAVSDELEAQGALDIVQALLAGSPPAGKGDA
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA