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The map label for this gene is mutM [H]

Identifier: 78049946

GI number: 78049946

Start: 5053538

End: 5054368

Strand: Reverse

Name: mutM [H]

Synonym: XCV4390

Alternate gene names: 78049946

Gene position: 5054368-5053538 (Counterclockwise)

Preceding gene: 78049948

Following gene: 78049945

Centisome position: 97.6

GC content: 61.85

Gene sequence:

>831_bases
TTGTTGGATGCGCTGATGCCCGAGTTGCCCGAGGTCGAAACGACGTTGCGTGGCCTGTCGCCGCATCTGGTTGGGCAGCG
GATCCATGGCGTGATCCTGCGTCGGCCCGATTTGCGCTGGCCGATTCCCGAGCAGATCGAGCGCTTGCTCCCCGGCGCTA
CCATTACCAACGTGCGCCGACGCGCGAAATATCTGTTGATCGATACAGATGCGGGCGGCAGCGCGCTGTTGCATCTGGGG
ATGTCCGGAAGTCTGCGGGTGCTGCCAGGCGACACCCTGCCGCGGGCGCATGACCATGTGGATATCAGTCTGCAGAACGG
GCGCGTGCTGCGCTTCAACGATCCGCGTCGCTTTGGCTGCCTGCTGTGGCAATCCGGCACACAAACCCATGAGTTGCTCG
CTGCGCTTGGTCCAGAACCATTATCGGACGCATTTACTGGCGATTATCTCCACGCACTGGCACAAGGGCGGCGTGCCGCC
GTCAAAACCTTTTTGATGGATCAGGCCGTGGTTGTCGGGGTTGGAAATATCTACGCTGCCGAAAGCCTGCATCGGGCGGG
AATCAGTCCGCTGCGCGAGGCGGGAAAAGTGTCGCTGGCGCGGTATCGGCGTCTGGCTGACGCAGTGAAAGACATCCTGG
CGTATGCCATCCAACGCGGCGGGACTACCTTGCGCGACTTCATCAGCCCGGATGGTGCGCCTGGCTATTTCGAGCAGGAA
CTCTCTGTGTACGGGCGCGAAGGCGAGGCCTGCAAGCAATGTGGGCGGGTGTTGAAGCACGCGACGATTGGTCAACGCGC
CACGGTGTGGTGCGGGAGCTGTCAGCGATAA

Upstream 100 bases:

>100_bases
AAGGCAGGGATAGACCAGCGATGGCACGCCGGCAGCGTCGCATTGATTGCATTTGAGTGTTTCGACCCCATTAGCTGCCT
TGCCGGTATGTGACCGGCGC

Downstream 100 bases:

>100_bases
GCGCGATATCGCGCCGACGCGGTGTTTGAGCACTGGTACTCTCGCGATCGTGTCACGATCGTTGCCGCGCAAGTCACAAC
AAAGCGACTCCGAGCAACTC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MLDALMPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYLLIDTDAGGSALLHLG
MSGSLRVLPGDTLPRAHDHVDISLQNGRVLRFNDPRRFGCLLWQSGTQTHELLAALGPEPLSDAFTGDYLHALAQGRRAA
VKTFLMDQAVVVGVGNIYAAESLHRAGISPLREAGKVSLARYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQE
LSVYGREGEACKQCGRVLKHATIGQRATVWCGSCQR

Sequences:

>Translated_276_residues
MLDALMPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYLLIDTDAGGSALLHLG
MSGSLRVLPGDTLPRAHDHVDISLQNGRVLRFNDPRRFGCLLWQSGTQTHELLAALGPEPLSDAFTGDYLHALAQGRRAA
VKTFLMDQAVVVGVGNIYAAESLHRAGISPLREAGKVSLARYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQE
LSVYGREGEACKQCGRVLKHATIGQRATVWCGSCQR
>Mature_276_residues
MLDALMPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYLLIDTDAGGSALLHLG
MSGSLRVLPGDTLPRAHDHVDISLQNGRVLRFNDPRRFGCLLWQSGTQTHELLAALGPEPLSDAFTGDYLHALAQGRRAA
VKTFLMDQAVVVGVGNIYAAESLHRAGISPLREAGKVSLARYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQE
LSVYGREGEACKQCGRVLKHATIGQRATVWCGSCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=271, Percent_Identity=52.7675276752767, Blast_Score=290, Evalue=7e-80,
Organism=Escherichia coli, GI1786932, Length=274, Percent_Identity=26.2773722627737, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30282; Mature: 30282

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDALMPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRR
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHCCCCHHHHHHH
RAKYLLIDTDAGGSALLHLGMSGSLRVLPGDTLPRAHDHVDISLQNGRVLRFNDPRRFGC
HCEEEEEECCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCEEE
LLWQSGTQTHELLAALGPEPLSDAFTGDYLHALAQGRRAAVKTFLMDQAVVVGVGNIYAA
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCHHEEECCCHHHH
ESLHRAGISPLREAGKVSLARYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHH
LSVYGREGEACKQCGRVLKHATIGQRATVWCGSCQR
HHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure
MLDALMPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRR
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHCCCCHHHHHHH
RAKYLLIDTDAGGSALLHLGMSGSLRVLPGDTLPRAHDHVDISLQNGRVLRFNDPRRFGC
HCEEEEEECCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCEEE
LLWQSGTQTHELLAALGPEPLSDAFTGDYLHALAQGRRAAVKTFLMDQAVVVGVGNIYAA
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCHHEEECCCHHHH
ESLHRAGISPLREAGKVSLARYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHH
LSVYGREGEACKQCGRVLKHATIGQRATVWCGSCQR
HHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]