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The map label for this gene is pyrF [H]

Identifier: 78049934

GI number: 78049934

Start: 5040788

End: 5041519

Strand: Reverse

Name: pyrF [H]

Synonym: XCV4378

Alternate gene names: 78049934

Gene position: 5041519-5040788 (Counterclockwise)

Preceding gene: 78049935

Following gene: 78049928

Centisome position: 97.36

GC content: 70.08

Gene sequence:

>732_bases
ATGAGCCGCGCGCCCTTGCCGCTGGCCGCGCATGAGCGGCTGATCTTCGCGCTGGATGTGCCCGGCCACGATGAAGCGAT
CGCCTGGGTGGACCGGCTCGGCGATTCGGTGTCGTTCTACAAGATCGGCATGGAGCTGCTGGCATCGGGCGAGTACTTCC
ACGTGCTCGATGCGCTGGCCAAGCGCGACAAGCGCGTGTTCGTGGACCTCAAGTTCTTCGACATTCCCGCCACCGTGGCC
GGCACCATCCGCCGCCTGGCGCAGTGGCCGGTGAGTTATTGCACGGTGCACGGCTGGCACGCCGGCATGCTGCAGGCCGC
CGCCGAGGCCAATCACGGTGACATGCGCCTGCTGGCGGTCACGGTACTGACGTCGATGGGCCGCCCGGACCTGGCGGCAA
TGGGCATCGACCGTGAACCGGTGGACGTGGTGGTGGAACGCGCGCTGGCTGCGCAGGCCGCCGGGATCGATGGCGTGATC
GCTTCGGGGCAGGAAGCCGGCCCGATCCGCCGCGCCACTGGCCCGGACTTTTCGATCGTCTGCCCCGGCATCCGCCCCGG
CGGCCCGGTCGGCGACGACCAGCAACGCACGGTCGGCGTGGCGCAGGCCTTCACCGACGGCGCCGACGCGATCGTCGTTG
GCCGCCCGATCCGCCAGGCGAGCGACCCTGCAGCCGCTGCCACCGCCATCCAGGACGAGATCCGCGCGGCACTGCCGCAG
AACGGAAACTGA

Upstream 100 bases:

>100_bases
CCAGCTACGGCGGCTGGGAGCCGGCGCAGTTCAACAACGACTACGCGCAACCCTGGCAAAAGCGCCACGACGCCAAGCGC
GCTGCGCTGGAGGTGGCCCG

Downstream 100 bases:

>100_bases
TCGGGCCGAAGCAGCGGCCAGCTTCCAAATAAATCAATAGGTAGGCGGCAACAATTAAAGCATTGCTTTAATGTGAAAGT
CTCGTTAACATGCCAGCGTC

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSRAPLPLAAHERLIFALDVPGHDEAIAWVDRLGDSVSFYKIGMELLASGEYFHVLDALAKRDKRVFVDLKFFDIPATVA
GTIRRLAQWPVSYCTVHGWHAGMLQAAAEANHGDMRLLAVTVLTSMGRPDLAAMGIDREPVDVVVERALAAQAAGIDGVI
ASGQEAGPIRRATGPDFSIVCPGIRPGGPVGDDQQRTVGVAQAFTDGADAIVVGRPIRQASDPAAAATAIQDEIRAALPQ
NGN

Sequences:

>Translated_243_residues
MSRAPLPLAAHERLIFALDVPGHDEAIAWVDRLGDSVSFYKIGMELLASGEYFHVLDALAKRDKRVFVDLKFFDIPATVA
GTIRRLAQWPVSYCTVHGWHAGMLQAAAEANHGDMRLLAVTVLTSMGRPDLAAMGIDREPVDVVVERALAAQAAGIDGVI
ASGQEAGPIRRATGPDFSIVCPGIRPGGPVGDDQQRTVGVAQAFTDGADAIVVGRPIRQASDPAAAATAIQDEIRAALPQ
NGN
>Mature_242_residues
SRAPLPLAAHERLIFALDVPGHDEAIAWVDRLGDSVSFYKIGMELLASGEYFHVLDALAKRDKRVFVDLKFFDIPATVAG
TIRRLAQWPVSYCTVHGWHAGMLQAAAEANHGDMRLLAVTVLTSMGRPDLAAMGIDREPVDVVVERALAAQAAGIDGVIA
SGQEAGPIRRATGPDFSIVCPGIRPGGPVGDDQQRTVGVAQAFTDGADAIVVGRPIRQASDPAAAATAIQDEIRAALPQN
GN

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=228, Percent_Identity=37.280701754386, Blast_Score=123, Evalue=1e-29,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 25693; Mature: 25561

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAPLPLAAHERLIFALDVPGHDEAIAWVDRLGDSVSFYKIGMELLASGEYFHVLDALA
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHH
KRDKRVFVDLKFFDIPATVAGTIRRLAQWPVSYCTVHGWHAGMLQAAAEANHGDMRLLAV
HCCCEEEEEEEEECCCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHCCCCCCHHHHHH
TVLTSMGRPDLAAMGIDREPVDVVVERALAAQAAGIDGVIASGQEAGPIRRATGPDFSIV
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEE
CPGIRPGGPVGDDQQRTVGVAQAFTDGADAIVVGRPIRQASDPAAAATAIQDEIRAALPQ
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
NGN
CCC
>Mature Secondary Structure 
SRAPLPLAAHERLIFALDVPGHDEAIAWVDRLGDSVSFYKIGMELLASGEYFHVLDALA
CCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHH
KRDKRVFVDLKFFDIPATVAGTIRRLAQWPVSYCTVHGWHAGMLQAAAEANHGDMRLLAV
HCCCEEEEEEEEECCCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHCCCCCCHHHHHH
TVLTSMGRPDLAAMGIDREPVDVVVERALAAQAAGIDGVIASGQEAGPIRRATGPDFSIV
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEE
CPGIRPGGPVGDDQQRTVGVAQAFTDGADAIVVGRPIRQASDPAAAATAIQDEIRAALPQ
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
NGN
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]