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The map label for this gene is hemL [H]

Identifier: 78049904

GI number: 78049904

Start: 4999904

End: 5001367

Strand: Reverse

Name: hemL [H]

Synonym: XCV4348

Alternate gene names: 78049904

Gene position: 5001367-4999904 (Counterclockwise)

Preceding gene: 78049905

Following gene: 78049903

Centisome position: 96.58

GC content: 67.55

Gene sequence:

>1464_bases
ATGATGGCACCGACAATGAGCGTGACTTCCGCGATTTCGCAATGGCCCGATGTGGACCAGCTGTATCGCCGCTTCGATGC
GTTGGTCAAACAGCCGATGCGGCCGGTCCGGCGCGAAGGCATGGACAAGGTGATGCGCTACTTCGAGCAGCGCTGCCAAG
GCTCCAAGCAGTTGGGCGACGCCGCGCAGCGGGTGATTCCCGGCGGCGTGCAGCACAACCTGGCCTTCAATTACCCGTTC
TCGCTGGCGATGCGCAGCGCCGAGGGCGCCTACCTGACCGACGTCGACGACAACCGCTACATCGATTTCCTGCAGGCCGG
CGGACCGACCTTGCTCGGCTCCAACCCGCCGGCGTTGCGCGCACGCGTCAACGAGGTGCTGGACCAGTGCGGACCGGTGA
CCGGACTGCTGCACGAATACGAGGTCAAACTGGCCGAGCTGGTCTGCGCCAGCATGCCGGCGGTGGAGATGGTGCGCCTG
CTCGGTTCGGGAACCGAGGCGGTGATGGGCGCGGTGCGCCTGGCGCGCGCGTATACCCGCAAGCGCTGGATCATCAAGAT
CGGCGGTGCGTATCACGGCTGGAGCGACCAGTTGGTGTACGGCCTGCGCCTGCCCGGCACCGGCCGCATGGAAGCGATCG
GCATTCCGCGTGGGGCGACCGCGCATACCCAGGAATGCCTGCCCAACGATCTGGACGCGTTGCGCCGCAAGCTGCAATTC
AATCGCCTGCGCGGCGGCACCGCGGCGGTGCTGCTGGAACCGCTGGGGCCGGAGAGCGGCACCCGCCCGGTGCATGCGGA
CTACAACCGCCAGGTGCGCGCGCTGTGCGACGAGTTCGGGGCGCTGCTGATCTTCGACGAAGTGGTCACCGGTTTCCGGT
TGGGCCCCGGCGGTGCGCAAGGCTACTTCGGCGTTGCGCCGGACATCACCGTGCTGGGCAAGTGCCTGGCCGGCGGCTAT
CCGATGGCCGGGGCGATCGGGGGCCGCCGCGAGGTCATGATGAGCCTGGTGGGCGGCATCGGCACGACCGCGCGGCGCGC
CTTTGTCGGCGGCACGCTCTCGGCCAATCCGCTGTCCTGCGTGGCCGGCTACTACGCGTTGCTGGAAGCGCAGCAGAACG
ATGCCGCCGGCCGCGCCGGTCGCGCCGGCGATCGCCTGCGTGCGGGTCTGGAGGCGATCATCCAGCGCCGCGGATTGCCG
TACGTGGTCTACAACATGGGCTCGATCGTGCACCTGCAGACCTCCGGCGTGCTGCTGCTGGACACCGGCAACCTCTACAA
ACTCTGGCGCGTGCGCAACGAAGCCAAGGCGCGCAAGCACATGATGGAAGAGATGGGCGCGGCGTATTCGGCGCATGGCC
TGATCACCCTGGCCGGTAGCCGCATCTACACCAGCATGGCCGACACCGATGCGGTGATCGACGAGGCCCTGAACCGTTTC
GACGATGTCTTCGCACTGGTCTGA

Upstream 100 bases:

>100_bases
GTGCGGCGCGCGAGCCCGACCTCGCTGCCGGCCTGCTGCGGGTGCTGACGGCGCTGGATTCCAGCCGGCACACGTCCGGC
GCGTCCTCCCTTTCCCAGAC

Downstream 100 bases:

>100_bases
GCCGATGAACGCCACCGATGCCCTGCGCGACACCTGGCTGCAGACCCGCGAACGGCTGCAGGCCTCCCACTTGCTCGGCG
ACGATGACGCGGCCTTGTCG

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MMAPTMSVTSAISQWPDVDQLYRRFDALVKQPMRPVRREGMDKVMRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPF
SLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALRARVNEVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRL
LGSGTEAVMGAVRLARAYTRKRWIIKIGGAYHGWSDQLVYGLRLPGTGRMEAIGIPRGATAHTQECLPNDLDALRRKLQF
NRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCDEFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLAGGY
PMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANPLSCVAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLP
YVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNEAKARKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRF
DDVFALV

Sequences:

>Translated_487_residues
MMAPTMSVTSAISQWPDVDQLYRRFDALVKQPMRPVRREGMDKVMRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPF
SLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALRARVNEVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRL
LGSGTEAVMGAVRLARAYTRKRWIIKIGGAYHGWSDQLVYGLRLPGTGRMEAIGIPRGATAHTQECLPNDLDALRRKLQF
NRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCDEFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLAGGY
PMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANPLSCVAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLP
YVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNEAKARKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRF
DDVFALV
>Mature_487_residues
MMAPTMSVTSAISQWPDVDQLYRRFDALVKQPMRPVRREGMDKVMRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPF
SLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALRARVNEVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRL
LGSGTEAVMGAVRLARAYTRKRWIIKIGGAYHGWSDQLVYGLRLPGTGRMEAIGIPRGATAHTQECLPNDLDALRRKLQF
NRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCDEFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLAGGY
PMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANPLSCVAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLP
YVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNEAKARKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRF
DDVFALV

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=357, Percent_Identity=28.0112044817927, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI284507298, Length=163, Percent_Identity=34.3558282208589, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786349, Length=437, Percent_Identity=37.2997711670481, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789016, Length=424, Percent_Identity=29.2452830188679, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787560, Length=349, Percent_Identity=30.0859598853868, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI145693181, Length=314, Percent_Identity=31.2101910828025, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788044, Length=292, Percent_Identity=31.5068493150685, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789759, Length=286, Percent_Identity=29.3706293706294, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786991, Length=300, Percent_Identity=30.6666666666667, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21357415, Length=330, Percent_Identity=28.7878787878788, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 52858; Mature: 52858

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAPTMSVTSAISQWPDVDQLYRRFDALVKQPMRPVRREGMDKVMRYFEQRCQGSKQLGD
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAQRVIPGGVQHNLAFNYPFSLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALR
HHHHHCCCCCCCCEEECCCHHHHEECCCCCEEEECCCCCEEHHHHCCCCEEECCCCHHHH
ARVNEVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRLLGSGTEAVMGAVRLARAYTR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
KRWIIKIGGAYHGWSDQLVYGLRLPGTGRMEAIGIPRGATAHTQECLPNDLDALRRKLQF
CEEEEEECCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHH
NRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCDEFGALLIFDEVVTGFRLGPGGAQ
HHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCEECCCCCCC
GYFGVAPDITVLGKCLAGGYPMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANPLSC
CCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHH
VAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLPYVVYNMGSIVHLQTSGVLLL
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEE
DTGNLYKLWRVRNEAKARKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRF
ECCCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
DDVFALV
HHHHHCC
>Mature Secondary Structure
MMAPTMSVTSAISQWPDVDQLYRRFDALVKQPMRPVRREGMDKVMRYFEQRCQGSKQLGD
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAQRVIPGGVQHNLAFNYPFSLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALR
HHHHHCCCCCCCCEEECCCHHHHEECCCCCEEEECCCCCEEHHHHCCCCEEECCCCHHHH
ARVNEVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRLLGSGTEAVMGAVRLARAYTR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
KRWIIKIGGAYHGWSDQLVYGLRLPGTGRMEAIGIPRGATAHTQECLPNDLDALRRKLQF
CEEEEEECCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHH
NRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCDEFGALLIFDEVVTGFRLGPGGAQ
HHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCEECCCCCCC
GYFGVAPDITVLGKCLAGGYPMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANPLSC
CCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHH
VAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLPYVVYNMGSIVHLQTSGVLLL
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEE
DTGNLYKLWRVRNEAKARKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRF
ECCCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
DDVFALV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA