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The map label for this gene is fucP [H]

Identifier: 78049845

GI number: 78049845

Start: 4922386

End: 4923687

Strand: Reverse

Name: fucP [H]

Synonym: XCV4289

Alternate gene names: 78049845

Gene position: 4923687-4922386 (Counterclockwise)

Preceding gene: 78049848

Following gene: 78049844

Centisome position: 95.08

GC content: 64.44

Gene sequence:

>1302_bases
ATGCATCACAGTGACATTGCCGCGTCGCCGCGCGGCAACCTGGCGCGTACCGCCATGGTTCCCCTGTTGTTGATCGTCAG
CCTGTTCTTTCTATGGGGCATGGCCAACAACCTCAACGACATCCTGATCAAGCAGTTCAAGAAGGCGTTCGAGCTGACCG
ACCTGCAGGCCGGGCTGGTGCAGAGCGCGTTCTACATGGGCTATTTCGTGTTCGCGATGCCGGCGGCGATGTTCATGCGC
CGCTACAGCTACAAGGCCGCGGTGGTGCTGGGCCTGCTGCTGTACGCCTGCGGTGCGTTCCTGTTCTATCCGGCCGCGCA
GGTGCACACCTACTGGCTGTTCCTGCTGGCGCTGTTCGTGATCGCCAGCGGCCTGGCGTTCCTGGAAACCACGGCCAACC
CGCTGGTGACCGTCCTTGGTCCGGCCGATGGCGCGGCGCGACGCCTGAATCTTGCGCAGGCGTTCAATCCGCTGGGCTCG
ATTACCGGCGTGCTGGTCGGCCAGCACTTCATCTTCTCCGGCGTGGAGCACACCCCGGCCGAACTGGCAGCGATGGCGCC
GGCCGCGCGCGAGGCGTTCTTCGCCACCGAATCGGCGGCCGTGCAGATGCCCTACCTGATCATCGGTGCGGTGGTGGTGC
TGTGGGCGATCCTGATCGCGCTGGTGCGTTTTCCCAGCGGCGCGCCGGAGGCAGACACCGGCGTTGCGCCCAGGCGCGCA
CGCTTCAGCGAACTGCTGCGTAACCGCTTGTTCGTGTTTGCGGTGGTGGCGCAGTTCTTTTACGTGGGCGCGCAGGTCGG
CATCTGGAGTTATCTGATCCGCTATCTGCAGGACGCAGTGCCTGGCACGCCGGAAAAAACCGCTGCGACCTATCTGACCA
TCTCGCTGGTGCTGTTCATGGCCGGCCGCTTCATCGGCACTGCGCTGTTGCGTTACCTGGCGCCTGCGAAGCTGTTGGCA
AGTTTTGCCGTGATCAATCTGGTCTTGTGCGCGGTGGCCATCGCGCTACCCGGCTGGACCGGGCTGTACGCGCTGGTGGC
GGCCAGCGTGTTCATGTCGGTGATGTTCCCGACCATTTTTGCGCTGGGCCTGGACGGCATGCACGACGATGCCCGCAAGC
TGGGCTCGTCCATGCTGGTGATGTCCATCATCGGCGGTGCCTTGCTTACGGCGGTGATGGGCGCGGTATCGGATATGGCC
GGCATCCACTGGGCGATGGTGGTGCCGGGTGCGTGCTTTGCGGTGATTTTGTCGTTCGCGTTGCGCGCACGTCGCGCGGC
GCCCGTCGTTGCAGGAGCCTGA

Upstream 100 bases:

>100_bases
AAATATAAACAAAGATTTTATATTTGCATGGCGCTGGCCTGCGCAGTACGCTCGCCCGATTGCAACGCAAGCGCCACAGC
CTTGGGAGGGGAACGGTCGC

Downstream 100 bases:

>100_bases
GCATGCCGCGCCTTTGTTATGTGCTGGATCTACACGACGATGCAGCGCTGATCGCCGAGTACGAGCGCTGGCATCAGCCC
ACCGAGGTGTGGCCGGAGGT

Product: L-fucose:H+ symporter

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MHHSDIAASPRGNLARTAMVPLLLIVSLFFLWGMANNLNDILIKQFKKAFELTDLQAGLVQSAFYMGYFVFAMPAAMFMR
RYSYKAAVVLGLLLYACGAFLFYPAAQVHTYWLFLLALFVIASGLAFLETTANPLVTVLGPADGAARRLNLAQAFNPLGS
ITGVLVGQHFIFSGVEHTPAELAAMAPAAREAFFATESAAVQMPYLIIGAVVVLWAILIALVRFPSGAPEADTGVAPRRA
RFSELLRNRLFVFAVVAQFFYVGAQVGIWSYLIRYLQDAVPGTPEKTAATYLTISLVLFMAGRFIGTALLRYLAPAKLLA
SFAVINLVLCAVAIALPGWTGLYALVAASVFMSVMFPTIFALGLDGMHDDARKLGSSMLVMSIIGGALLTAVMGAVSDMA
GIHWAMVVPGACFAVILSFALRARRAAPVVAGA

Sequences:

>Translated_433_residues
MHHSDIAASPRGNLARTAMVPLLLIVSLFFLWGMANNLNDILIKQFKKAFELTDLQAGLVQSAFYMGYFVFAMPAAMFMR
RYSYKAAVVLGLLLYACGAFLFYPAAQVHTYWLFLLALFVIASGLAFLETTANPLVTVLGPADGAARRLNLAQAFNPLGS
ITGVLVGQHFIFSGVEHTPAELAAMAPAAREAFFATESAAVQMPYLIIGAVVVLWAILIALVRFPSGAPEADTGVAPRRA
RFSELLRNRLFVFAVVAQFFYVGAQVGIWSYLIRYLQDAVPGTPEKTAATYLTISLVLFMAGRFIGTALLRYLAPAKLLA
SFAVINLVLCAVAIALPGWTGLYALVAASVFMSVMFPTIFALGLDGMHDDARKLGSSMLVMSIIGGALLTAVMGAVSDMA
GIHWAMVVPGACFAVILSFALRARRAAPVVAGA
>Mature_433_residues
MHHSDIAASPRGNLARTAMVPLLLIVSLFFLWGMANNLNDILIKQFKKAFELTDLQAGLVQSAFYMGYFVFAMPAAMFMR
RYSYKAAVVLGLLLYACGAFLFYPAAQVHTYWLFLLALFVIASGLAFLETTANPLVTVLGPADGAARRLNLAQAFNPLGS
ITGVLVGQHFIFSGVEHTPAELAAMAPAAREAFFATESAAVQMPYLIIGAVVVLWAILIALVRFPSGAPEADTGVAPRRA
RFSELLRNRLFVFAVVAQFFYVGAQVGIWSYLIRYLQDAVPGTPEKTAATYLTISLVLFMAGRFIGTALLRYLAPAKLLA
SFAVINLVLCAVAIALPGWTGLYALVAASVFMSVMFPTIFALGLDGMHDDARKLGSSMLVMSIIGGALLTAVMGAVSDMA
GIHWAMVVPGACFAVILSFALRARRAAPVVAGA

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family [H]

Homologues:

Organism=Escherichia coli, GI1789166, Length=417, Percent_Identity=49.400479616307, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46353; Mature: 46353

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHSDIAASPRGNLARTAMVPLLLIVSLFFLWGMANNLNDILIKQFKKAFELTDLQAGLV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
QSAFYMGYFVFAMPAAMFMRRYSYKAAVVLGLLLYACGAFLFYPAAQVHTYWLFLLALFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASGLAFLETTANPLVTVLGPADGAARRLNLAQAFNPLGSITGVLVGQHFIFSGVEHTPA
HHCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHH
ELAAMAPAAREAFFATESAAVQMPYLIIGAVVVLWAILIALVRFPSGAPEADTGVAPRRA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
RFSELLRNRLFVFAVVAQFFYVGAQVGIWSYLIRYLQDAVPGTPEKTAATYLTISLVLFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGRFIGTALLRYLAPAKLLASFAVINLVLCAVAIALPGWTGLYALVAASVFMSVMFPTIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ALGLDGMHDDARKLGSSMLVMSIIGGALLTAVMGAVSDMAGIHWAMVVPGACFAVILSFA
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRARRAAPVVAGA
HHHHHCCCCCCCC
>Mature Secondary Structure
MHHSDIAASPRGNLARTAMVPLLLIVSLFFLWGMANNLNDILIKQFKKAFELTDLQAGLV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
QSAFYMGYFVFAMPAAMFMRRYSYKAAVVLGLLLYACGAFLFYPAAQVHTYWLFLLALFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASGLAFLETTANPLVTVLGPADGAARRLNLAQAFNPLGSITGVLVGQHFIFSGVEHTPA
HHCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHH
ELAAMAPAAREAFFATESAAVQMPYLIIGAVVVLWAILIALVRFPSGAPEADTGVAPRRA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
RFSELLRNRLFVFAVVAQFFYVGAQVGIWSYLIRYLQDAVPGTPEKTAATYLTISLVLFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGRFIGTALLRYLAPAKLLASFAVINLVLCAVAIALPGWTGLYALVAASVFMSVMFPTIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ALGLDGMHDDARKLGSSMLVMSIIGGALLTAVMGAVSDMAGIHWAMVVPGACFAVILSFA
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRARRAAPVVAGA
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647 [H]