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The map label for this gene is cls [H]

Identifier: 78049807

GI number: 78049807

Start: 4880844

End: 4882367

Strand: Reverse

Name: cls [H]

Synonym: XCV4251

Alternate gene names: 78049807

Gene position: 4882367-4880844 (Counterclockwise)

Preceding gene: 78049808

Following gene: 78049805

Centisome position: 94.28

GC content: 65.42

Gene sequence:

>1524_bases
ATGCGCAGGGCGGGCCGTTTCGTTATTGCCCCCCTGTCTATGCACCGCCGTTGCGTTTGCGCGCGGCCAAGTCAGAATCG
GATTCCTGATGAAAACGGACCACTGATGCTGCCCGATTGGGTCACAGGTACCTGGCTGCTGGCGCTGGACTGGGCGATCC
GCCTGGCCGCGCTGCTATGGATTCCCGCCCGCACCACGCCGGGTGCCGCGCGCAGCTGGCTGCTGTTGATCGGCTTTGTG
CCAGTGGTCGGTCTGCCGCTGTACCTGTTGTTCGGCCACCCATGGTTGTCGCGGCTGCGGGTGGAGCGGCAAGCCACCGC
TTCGCAGGTGATTCGCGAACAACAACTGCCCTTGCATGCATTGCGCTGGATGCCGCAGGCAGACACCAGCAGTGCCGAAG
TGGTGCCGCTGATCGAACGCGAGGGCGATTTCATGCCCACCCTGGGCAACGCGGTGGAATTGCTCGACGACTACGCGCAG
TCGTTGCAGGCCCTGATCGCGGCGATCGACGCGGCCGACAAACGTGTGCACCTGCTGTACTACCTGATGTTCGACGATGC
GGTGGGCGAGGCGGTGGTGGCGGCGCTGGAACGCGCCAGCGCGCGCGGCGTGCGTTGCCGCGTGCTGCTGGATGCGGTGG
GCGCCAAGCGCGGCCTGCGCCGTTACCGCAAGCGCCTGCAGGACGGCGGCGTGCAGGTGCTGGCGGTACTGCCGGGCGGC
CTGCGCTGGCGTCGCAGCGGCCGCATGGATCTGCGCAACCATCGCAAGATTGCGGTGCTCGACAACCGGGTGGCGTTTGT
CGGTTCGCAGAACCTGGCCGAAGCCGGCTTCATCCATGGCGTGCCCAATCGCGAATTGGTGGCACGCGTGCGCGGGCCGG
TGGTCAATCATCTGGAAGCGGTCTTCGCCAGCGACTGGTTCACCGAAACCGGAGAGCGGCTGAATGTGTGGCCCGATGCA
CCGGTGTGCGAGGCCAATATCGCGACGCAGTTGCTGCCCAGCGGGCCGGCGTACCCGTTCGAAAATGCGCGCGATGCGAT
CAATGCGGTGATCCATCTGGCGCGGCGCAAGGTGGTGCTGGTCACGCCGTACTTCGTGCCCGACGAAGCCTTGCTGAGCG
CATTGCGCATCGCCGCCGTCTCGGGCGTGGACGTGCAGCTGATCCTGTCCGAGCACAACAATCAACGCCTGGCCGCGTGG
GCGCAGGAAGCCTATTTCGAAGAACTGCTGCGTTGCGGGGTGAAGATTTCGCTGTATCGCCCGCACTTTCTGCACGCCAA
GCACCTGAGCATGGATGAAGACATCGCGCTGGTGGGCTCGATCAATCTGGACATCCGCTCGTTCGCGCTCAACGCCGAGA
TCGGCATGCTCTGCTACGACACTGGGGTGGTGCAGCGGTTGCGTGAGATCGAGCAGGATTATCTGGCCAACGCGCGGCAA
CTGACGTTGGAACAGTGGCGTCGCCGCCCGGCCTGGCGCCGCAGTCGCGAGGGCATTGCGCGGCTGGCCGACGCGTTGAT
GTAG

Upstream 100 bases:

>100_bases
ATCGGCATGACCACGCGCAGCGACTGGTATCCCACCCGGATGCAGTCGGCCTTCGTGCAGACGTTGCGGCAGGTCTGCGC
CGAACGCGTGCAGCCGGCCG

Downstream 100 bases:

>100_bases
GGCGCCTGGGTCAATCCAGGCGCATGACCTGAAAGACGTTGCCCTCCGGGTCGCGGCCGTCGTACATCTGGTACGCAAAG
CCGGGGTAACGTTTGAGCTC

Product: cardiolipin synthase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MRRAGRFVIAPLSMHRRCVCARPSQNRIPDENGPLMLPDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFV
PVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQLPLHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQ
SLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVAALERASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGG
LRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAGFIHGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLNVWPDA
PVCEANIATQLLPSGPAYPFENARDAINAVIHLARRKVVLVTPYFVPDEALLSALRIAAVSGVDVQLILSEHNNQRLAAW
AQEAYFEELLRCGVKISLYRPHFLHAKHLSMDEDIALVGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQ
LTLEQWRRRPAWRRSREGIARLADALM

Sequences:

>Translated_507_residues
MRRAGRFVIAPLSMHRRCVCARPSQNRIPDENGPLMLPDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFV
PVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQLPLHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQ
SLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVAALERASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGG
LRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAGFIHGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLNVWPDA
PVCEANIATQLLPSGPAYPFENARDAINAVIHLARRKVVLVTPYFVPDEALLSALRIAAVSGVDVQLILSEHNNQRLAAW
AQEAYFEELLRCGVKISLYRPHFLHAKHLSMDEDIALVGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQ
LTLEQWRRRPAWRRSREGIARLADALM
>Mature_507_residues
MRRAGRFVIAPLSMHRRCVCARPSQNRIPDENGPLMLPDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFV
PVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQLPLHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQ
SLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVAALERASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGG
LRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAGFIHGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLNVWPDA
PVCEANIATQLLPSGPAYPFENARDAINAVIHLARRKVVLVTPYFVPDEALLSALRIAAVSGVDVQLILSEHNNQRLAAW
AQEAYFEELLRCGVKISLYRPHFLHAKHLSMDEDIALVGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQ
LTLEQWRRRPAWRRSREGIARLADALM

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=471, Percent_Identity=32.2717622080679, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1787007, Length=333, Percent_Identity=30.03003003003, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 56913; Mature: 56913

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAGRFVIAPLSMHRRCVCARPSQNRIPDENGPLMLPDWVTGTWLLALDWAIRLAALLW
CCCCCCEEEEEHHHCCEEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHH
IPARTTPGAARSWLLLIGFVPVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQLPLHA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQSLQALIAAIDAADKRVHLLY
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YLMFDDAVGEAVVAALERASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGG
EEEHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAGFIHGVPNRELVARVRGPVVNHLEA
CEECCCCCCCCCCCCEEEEECCEEEEECCCCCHHCCCCCCCCCHHHHHHHHCHHHHHHHH
VFASDWFTETGERLNVWPDAPVCEANIATQLLPSGPAYPFENARDAINAVIHLARRKVVL
HHHHHHHHCCCCEEECCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VTPYFVPDEALLSALRIAAVSGVDVQLILSEHNNQRLAAWAQEAYFEELLRCGVKISLYR
EECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEC
PHFLHAKHLSMDEDIALVGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQ
CCEECHHHCCCCCCEEEEEEECCEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCHHH
LTLEQWRRRPAWRRSREGIARLADALM
HHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRAGRFVIAPLSMHRRCVCARPSQNRIPDENGPLMLPDWVTGTWLLALDWAIRLAALLW
CCCCCCEEEEEHHHCCEEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHH
IPARTTPGAARSWLLLIGFVPVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQLPLHA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQSLQALIAAIDAADKRVHLLY
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YLMFDDAVGEAVVAALERASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGG
EEEHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAGFIHGVPNRELVARVRGPVVNHLEA
CEECCCCCCCCCCCCEEEEECCEEEEECCCCCHHCCCCCCCCCHHHHHHHHCHHHHHHHH
VFASDWFTETGERLNVWPDAPVCEANIATQLLPSGPAYPFENARDAINAVIHLARRKVVL
HHHHHHHHCCCCEEECCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VTPYFVPDEALLSALRIAAVSGVDVQLILSEHNNQRLAAWAQEAYFEELLRCGVKISLYR
EECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEC
PHFLHAKHLSMDEDIALVGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQ
CCEECHHHCCCCCCEEEEEEECCEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCHHH
LTLEQWRRRPAWRRSREGIARLADALM
HHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA