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The map label for this gene is map [H]

Identifier: 78049450

GI number: 78049450

Start: 4479319

End: 4480065

Strand: Reverse

Name: map [H]

Synonym: XCV3894

Alternate gene names: 78049450

Gene position: 4480065-4479319 (Counterclockwise)

Preceding gene: 78049451

Following gene: 78049448

Centisome position: 86.51

GC content: 62.78

Gene sequence:

>747_bases
ATGGCGGTGTCTGGCCAGCTCCTGGCGCAGGTATTCGATGCGCTGGATCGCTTGCCGCTGGAAGGTCGCAGCACGCTGGA
ACTCAACGGGTTTGTCGAGCGCATGATTGTCGATGAGCTCGACGCACGGCCTGCGAGCAAGGGGCAGTACGGTTTCGAGT
TCGTACTCAACGCATCCATCGACGATGTGGTCTGCCATGGCGTGCCATCGGCCGACGACGTGTTGCGCAGCGGGCAGATC
GTCAACCTGGACATTACGCTGGAAAAGAACGGCTATATCGCCGATTCCAGTACCACGTACCTGGTGGGCGAGGTCGCTTA
CCCGGCACGTCGCCTGGTGCAGGCCACGTATCAGGCGATGTGGAAAGGGATTGCAGCGGTGCGCCCGGGCGCGCGCTTGG
GCGATATCGGCCATGCCATTGCGCGGCACGCGCGTGCGCACGGCTATAGCGTGGTCAAGGAATACTGCGGGCACGGCATC
GGCCGTGAGATGCATGAAGACCCGCAAATTCTGCATTACGGCCACGCGGGCACTGGCTTGGAACTGCAGGAAGGCATGGT
GTTCACCATCGAGCCGATGATCAACCAGGGCCGTGCGGCGATCCGTTCGCAACCGGATCAGTGGCCGGTGCATACGCGCG
ATGGCAGGTTGTCGGCGCAGTTCGAACATACCGTGGCGGTGACGCGCACTGGCGTACGTGTGTTGACCTTGCGGCCCGCC
GAAGTGCCGCTGTGCGTGGTGGAGTGA

Upstream 100 bases:

>100_bases
TTCAGCAGATCGTGGCCGAACAATTGCGCGCGGCGGGCGTACGGCCGCAAGCCTTGAAACCGGGCCGGGCGTGATCAAGT
CGCCCGACGAGATCGCGCTG

Downstream 100 bases:

>100_bases
CGCACCGCAACGCATGGCGTCAGGCGGCTGTCAGTCGGCCGGGACGCGCGGCGTCGCCTCTGGCCGGCGCGGAATCAGCG
GGGTGGTGTTGGTGTGCAGA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MAVSGQLLAQVFDALDRLPLEGRSTLELNGFVERMIVDELDARPASKGQYGFEFVLNASIDDVVCHGVPSADDVLRSGQI
VNLDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAMWKGIAAVRPGARLGDIGHAIARHARAHGYSVVKEYCGHGI
GREMHEDPQILHYGHAGTGLELQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGRLSAQFEHTVAVTRTGVRVLTLRPA
EVPLCVVE

Sequences:

>Translated_248_residues
MAVSGQLLAQVFDALDRLPLEGRSTLELNGFVERMIVDELDARPASKGQYGFEFVLNASIDDVVCHGVPSADDVLRSGQI
VNLDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAMWKGIAAVRPGARLGDIGHAIARHARAHGYSVVKEYCGHGI
GREMHEDPQILHYGHAGTGLELQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGRLSAQFEHTVAVTRTGVRVLTLRPA
EVPLCVVE
>Mature_247_residues
AVSGQLLAQVFDALDRLPLEGRSTLELNGFVERMIVDELDARPASKGQYGFEFVLNASIDDVVCHGVPSADDVLRSGQIV
NLDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAMWKGIAAVRPGARLGDIGHAIARHARAHGYSVVKEYCGHGIG
REMHEDPQILHYGHAGTGLELQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGRLSAQFEHTVAVTRTGVRVLTLRPAE
VPLCVVE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=238, Percent_Identity=41.1764705882353, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI40385867, Length=218, Percent_Identity=38.0733944954128, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1786364, Length=238, Percent_Identity=43.6974789915966, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788728, Length=225, Percent_Identity=29.3333333333333, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=244, Percent_Identity=38.1147540983607, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=223, Percent_Identity=41.2556053811659, Blast_Score=170, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21355531, Length=238, Percent_Identity=37.3949579831933, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24583427, Length=236, Percent_Identity=37.2881355932203, Blast_Score=154, Evalue=6e-38,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27137; Mature: 27006

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSGQLLAQVFDALDRLPLEGRSTLELNGFVERMIVDELDARPASKGQYGFEFVLNASI
CCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
DDVVCHGVPSADDVLRSGQIVNLDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAM
CHHHCCCCCCHHHHHHCCCEEEEEEEECCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHH
WKGIAAVRPGARLGDIGHAIARHARAHGYSVVKEYCGHGIGREMHEDPQILHYGHAGTGL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
ELQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGRLSAQFEHTVAVTRTGVRVLTLRPA
EECCCEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEEHEEEEEEECCEEEEEECCC
EVPLCVVE
CCCEEEEC
>Mature Secondary Structure 
AVSGQLLAQVFDALDRLPLEGRSTLELNGFVERMIVDELDARPASKGQYGFEFVLNASI
CCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
DDVVCHGVPSADDVLRSGQIVNLDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAM
CHHHCCCCCCHHHHHHCCCEEEEEEEECCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHH
WKGIAAVRPGARLGDIGHAIARHARAHGYSVVKEYCGHGIGREMHEDPQILHYGHAGTGL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
ELQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGRLSAQFEHTVAVTRTGVRVLTLRPA
EECCCEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEEHEEEEEEECCEEEEEECCC
EVPLCVVE
CCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]