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The map label for this gene is cysM [C]

Identifier: 78049301

GI number: 78049301

Start: 4326880

End: 4327983

Strand: Reverse

Name: cysM [C]

Synonym: XCV3745

Alternate gene names: 78049301

Gene position: 4327983-4326880 (Counterclockwise)

Preceding gene: 78049308

Following gene: 78049300

Centisome position: 83.58

GC content: 67.03

Gene sequence:

>1104_bases
ATGTCGCAGCGCCAGTGGGTGGCCGCCGCCATCCGGAAGATCGAGGCCGATTTCAATCGTTCGGCCGACACCCACCTGAT
TCCGATGGAACTGCCGGGCTATCCAGGCATCGACCTGTACTTCAAGGACGAGTCCAGCCACCCGACCGGCAGCCTCAAGC
ACCGCCTGGCGCGCTCGCTGTTCCTGTACGCGCTCACCAATGGCTGGCTGCGCGCCGGGCGCCCGGTGATCGAGGCGTCC
AGTGGCTCCACGGCCATTTCCGAAGCATATTTCGCGCGCCTGCTGGGCGTGCCCTTCATCGCGGTGATGCCCGCCTCGAC
CTCGCCGGAGAAGATCGCCGCGATTCAATTCCAGGGCGGCCGCTGCCACCTGGTCGAACGCGCCTGCGACCTGGACAGCG
CCTCGCACCAGCTCGCACGCGAGACCGGCGGGCACTTCATGGACCAGTTCACCTATGCCGAGCGTGCCACTGACTGGCGC
GCCAACAACAACATCGCCGAATCGATCTTCAAGCAACTGGCCGAAGAGCCGCACCCGATCCCGGACTGGATCGTCTGCAG
CCCCGGCACCGGCGGTACCAGCGCCACCCTGGGCCGCTACGTGCGCTATCGGCGCCATGCCACCCGCATCCTGTGCGCCG
ACCCGGAAGTGTCGGTGTTCTTCGACGGCTATTGCCGCGCAGTGGACGGCCAATGCCCCAAGGAGCTGGCCATCACCGGC
GGTTCGCGCATCGAAGGCATCGGCCGCCCGCGGGTGGAATCGAGCTTCATTGCCAGCTGCGTGGATGTGATGATCAAGGT
GCCCGATGCGCTGAGCCTGGCGGCCATGCGCCACGTCAGCGCCACGCTGGGCCGCCGCGTGGGCGGCTCCACCGGCACCA
ACTTCGTCGGCGTGCTGCAGGCTGCCCGGCGCATGCGCGACGAAGGCCGGCAGGGCTCCATCGTCACCATCCTGTGCGAT
GCCGGCGAACGATACGCGCACAGTTATTACGACCCGGCCTGGTACCAGGCGCGCGCGATCGATGTCAGCGACAGCGATAC
AGCCATTGCGCTGGCCGTGAACGGCGGCGATTTGCCTGCCTTGCCTTGTGCGGCGCTGGAATGA

Upstream 100 bases:

>100_bases
GCATAGCATCGGCCCCCAGCTGTCCGCCCGATGCGCTGGGTGCGTAAGCGGGCAGGTGGGGGCGGTAGAATTGAGGCTAC
TTTCGCAGCCAAGTCCTGCC

Downstream 100 bases:

>100_bases
CCGCCATATCCGGGACGTAGGCATCAAGGCGCTGCGCTCACCGCCACGCCCGTGCGATCGGTGTCCGCAGTCGGCAGGTC
CAGGCGCGCACCGTGCCCTC

Product: putative cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSQRQWVAAAIRKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGRPVIEAS
SGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIQFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWR
ANNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPKELAITG
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLQAARRMRDEGRQGSIVTILCD
AGERYAHSYYDPAWYQARAIDVSDSDTAIALAVNGGDLPALPCAALE

Sequences:

>Translated_367_residues
MSQRQWVAAAIRKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGRPVIEAS
SGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIQFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWR
ANNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPKELAITG
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLQAARRMRDEGRQGSIVTILCD
AGERYAHSYYDPAWYQARAIDVSDSDTAIALAVNGGDLPALPCAALE
>Mature_366_residues
SQRQWVAAAIRKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGRPVIEASS
GSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIQFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWRA
NNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPKELAITGG
SRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLQAARRMRDEGRQGSIVTILCDA
GERYAHSYYDPAWYQARAIDVSDSDTAIALAVNGGDLPALPCAALE

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=306, Percent_Identity=27.4509803921569, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI295821200, Length=306, Percent_Identity=27.4509803921569, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557415, Length=306, Percent_Identity=27.4509803921569, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=27.6094276094276, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=362, Percent_Identity=33.1491712707182, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17539800, Length=359, Percent_Identity=29.5264623955432, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17539640, Length=355, Percent_Identity=28.7323943661972, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562970, Length=329, Percent_Identity=26.4437689969605, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=27.2425249169435, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=28.1818181818182, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321594, Length=333, Percent_Identity=27.027027027027, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643623, Length=346, Percent_Identity=28.6127167630058, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129101, Length=346, Percent_Identity=28.6127167630058, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39896; Mature: 39764

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRQWVAAAIRKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSL
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYALTNGWLRAGRPVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIQFQGG
HHHHHHHCHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCC
RCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWRANNNIAESIFKQLAEEPHPI
EEEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
PDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPKELAITG
CCEEEECCCCCCCHHHHHHHHHHHHHHCEEEECCCCEEEEECCEEEECCCCCCHHHEECC
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLQ
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AARRMRDEGRQGSIVTILCDAGERYAHSYYDPAWYQARAIDVSDSDTAIALAVNGGDLPA
HHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCEEEEEEECCCCCCEEEEEECCCCCCC
LPCAALE
CCCCCCC
>Mature Secondary Structure 
SQRQWVAAAIRKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSL
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYALTNGWLRAGRPVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIQFQGG
HHHHHHHCHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCC
RCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWRANNNIAESIFKQLAEEPHPI
EEEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
PDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPKELAITG
CCEEEECCCCCCCHHHHHHHHHHHHHHCEEEECCCCEEEEECCEEEECCCCCCHHHEECC
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLQ
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AARRMRDEGRQGSIVTILCDAGERYAHSYYDPAWYQARAIDVSDSDTAIALAVNGGDLPA
HHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCEEEEEEECCCCCCEEEEEECCCCCCC
LPCAALE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]