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The map label for this gene is opdA [H]

Identifier: 78049300

GI number: 78049300

Start: 4324657

End: 4326681

Strand: Reverse

Name: opdA [H]

Synonym: XCV3744

Alternate gene names: 78049300

Gene position: 4326681-4324657 (Counterclockwise)

Preceding gene: 78049301

Following gene: 78049299

Centisome position: 83.55

GC content: 64.99

Gene sequence:

>2025_bases
ATGACCAACCCGCTGCTCGATCTGTCCGGACTGCCGTCCTTCGATGCGATCGGCCCCGAACACGTGGGCCCGGCGATCGA
CCAACTGCTCGCCGAGGCCGAGGCGGCGGTGAAGGCGGCCGAGCAGGTCAGCCCGGTGTGCTGGGACAGCTTCGTCACGC
CGCTGGACGATGCCACCGAGCGGCTATGGCGTGCGTGGGGGCAGGTGGGGCACCTGCAGGCGGTGGTCAACACGCCCGAG
CTGCGCGAGGCCTATAACTGCAATCTGCCCAAGGTGAGCCGCTTCGGCAGCGCGCTGGCGCAGAATCTGGCGCTGTATGC
GCAATACAAGGCGCTGGCGCAATCGCCGGAAGCCGCACACTTCGATGAGGCGCGTCGCAAGGTGCTGGAAAACGCGCTAC
GCGATTTCCGCTTGGGCGGTGCAGAACTCGATGATGCCGCCAAGGCGCGGTTCGCACAGATCCAGGAAGAACTCTCAGCG
TTGGCAGCCAAATTCTCGCAGAACGTACTCGACGCCACCGATGCGTGGTCGTACGTGACCGAAGACCAGACCCAGCTGTC
GGGCCTGCCGGCAGAAGTGATTGCCGCCGCGCGCGCCGCCGCCGAAAAGGACGGCGTGCCGGGCTGGAAATTCACCTTGC
AGATGCCGTGCTATCTGCCGGTGCAGAGCGATGCCGACAGCCGCGACCTGCGCGCGCGGCTGTATCGCGCCAATGCCGAG
CGCGCGTCCGAATTCGGCGATGCCACGCTGGACAACAGCGCCAACATCGATCGCATCCTGGCCCTGCGCGCCGAGTTGGC
GCAGCTGCTCGGCTTTGCCAGTTACGCCGACTATTCGGTTGCCACCAAGATGGCGCAGAGCCCCGACGAGGTGATGGGCT
TCCTGCGCGATCTGGCCGCGCGCGCCAAGCCGCATGCACAGCGCGACCGCGCCGAGCTGGAAGCCTTTGCGCGCGACGAG
TTGGGTCTGGATGAACTGCAGGCCTGGGACCTGGCCTACGCCTCGGAAAAACTCAAGCAGGCGCGTTACAGCTTTTCCGA
GCAGGAGGTGAAGCAGTACTTCACCGAACCGAAGGTACTGGCCGGCCTGTTCGATGTGATCCACAGCCTGTACGGGCTCA
CCGTCAAACCCGACAGCGCGCCGGTGTGGCACCCGGACGTGCGGTTCTACCGGTTGGAAGATGCGCAAGGCACCCTGGTT
GGCCAGTTCTATCTGGACTTGTACGCGCGCGAAGGCAAACGCGGCGGCGCGTGGATGGACGATTGCCGCAATCGCCGCAA
CACCGCCAACGGTGTGCAGACGCCGCTGGTGTATCTGGTGTGCAACTTCGGGCGTGGCAGCGGCGATGCACCGGCCACCT
TCCGCCACGGCGAAGTCACCACGCTGTTCCATGAAATGGGCCACGGCCTGCATCAGTTGCTCACGCAGATTGGCGAGCTG
GGCGTGGCCGGCATCAATGGCGTGGAATGGGACGCGGTAGAGCTGCCCAGCCAGTTCATGGAAAACTTCTGCTGGGAGTG
GGAGCGCGTGCAGGCGATGACCGCGCACGTTCAGACCGGCGAACCGCTGCCTCGGAATCTGTTCGATCGCCTGCTGGCGG
CGCGCAATTTCCAGAGCGGCATGTTCACCGTGCGTCAGCTGGAATTCGCCTTGTTCGACATGCAACTGCACAGCACCTAC
GACCCCTCGCAGGACAGCGTGCTGCAATTGATCGAGCGCGTGCGCGACGAAGTGGCGGTCAATCGGCCGCCGGCATGGAA
TCGCTTCCCGCATCAGTTCAGCCATATTTTTGCAGGTGGCTATGCGGCCGGCTATTACAGCTACAAGTGGGCCGAAGTGC
TCAGCGCCGATGCCTATGCCGCATTCGAAGAGGCGCCCGATCAACTGGAGCAGACCGGCGCACGGTTCCGCGCCGAGGTG
CTTGCGCGTGGCGGCAGTCGTCCGGCGGCGGAGAACTTCCGCGCGTTCCGCGGTCGGGCCCCGACCATCGATGCGCTGCT
ACGGCATAACGGCATGGCGGGCTGA

Upstream 100 bases:

>100_bases
TCGGTGCCGTGCTCACCTGCTGACGGTTGCGTGCCACGGTGTGCCTGCCACGTTTGCCGATCCTTGAATCCACTCATCCA
GTCCATTGCCGGAGCGCTCC

Downstream 100 bases:

>100_bases
CGGCGCCGATGGCGCAGTCGTCATCTGCTACCGTCGCCACGGCGTTCGCATTGCATTGAGGTGAGCTGTCCTATAACCGC
GACCTGGCGCCTCTTCGGGG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MTNPLLDLSGLPSFDAIGPEHVGPAIDQLLAEAEAAVKAAEQVSPVCWDSFVTPLDDATERLWRAWGQVGHLQAVVNTPE
LREAYNCNLPKVSRFGSALAQNLALYAQYKALAQSPEAAHFDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSA
LAAKFSQNVLDATDAWSYVTEDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAARAKPHAQRDRAELEAFARDE
LGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGTLV
GQFYLDLYAREGKRGGAWMDDCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTQIGEL
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHSTY
DPSQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEV
LARGGSRPAAENFRAFRGRAPTIDALLRHNGMAG

Sequences:

>Translated_674_residues
MTNPLLDLSGLPSFDAIGPEHVGPAIDQLLAEAEAAVKAAEQVSPVCWDSFVTPLDDATERLWRAWGQVGHLQAVVNTPE
LREAYNCNLPKVSRFGSALAQNLALYAQYKALAQSPEAAHFDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSA
LAAKFSQNVLDATDAWSYVTEDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAARAKPHAQRDRAELEAFARDE
LGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGTLV
GQFYLDLYAREGKRGGAWMDDCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTQIGEL
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHSTY
DPSQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEV
LARGGSRPAAENFRAFRGRAPTIDALLRHNGMAG
>Mature_673_residues
TNPLLDLSGLPSFDAIGPEHVGPAIDQLLAEAEAAVKAAEQVSPVCWDSFVTPLDDATERLWRAWGQVGHLQAVVNTPEL
REAYNCNLPKVSRFGSALAQNLALYAQYKALAQSPEAAHFDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSAL
AAKFSQNVLDATDAWSYVTEDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAER
ASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAARAKPHAQRDRAELEAFARDEL
GLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGTLVG
QFYLDLYAREGKRGGAWMDDCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTQIGELG
VAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHSTYD
PSQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEVL
ARGGSRPAAENFRAFRGRAPTIDALLRHNGMAG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=610, Percent_Identity=31.6393442622951, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI14149738, Length=668, Percent_Identity=27.6946107784431, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI156105687, Length=670, Percent_Identity=24.4776119402985, Blast_Score=163, Evalue=5e-40,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=48.9705882352941, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=686, Percent_Identity=31.3411078717201, Blast_Score=274, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71999758, Length=560, Percent_Identity=25.1785714285714, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32565901, Length=589, Percent_Identity=23.0899830220713, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319793, Length=686, Percent_Identity=28.134110787172, Blast_Score=294, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6322715, Length=653, Percent_Identity=24.6554364471669, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21356111, Length=680, Percent_Identity=30.2941176470588, Blast_Score=259, Evalue=5e-69,
Organism=Drosophila melanogaster, GI20129717, Length=417, Percent_Identity=27.3381294964029, Blast_Score=151, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 74927; Mature: 74795

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLDLSGLPSFDAIGPEHVGPAIDQLLAEAEAAVKAAEQVSPVCWDSFVTPLDDATE
CCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHH
RLWRAWGQVGHLQAVVNTPELREAYNCNLPKVSRFGSALAQNLALYAQYKALAQSPEAAH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSALAAKFSQNVLDATDAWSYVT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
CCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCHHHHHHHHHHHHHH
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKPHAQRDRAELEAFARDELGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVL
HCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHH
AGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGTLVGQFYLDLYAREGKRGGAWMD
HHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHH
DCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTQIGEL
HHHCCCCCCCCHHCCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHC
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
MFTVRQLEFALFDMQLHSTYDPSQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
YAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEVLARGGSRPAAENFRAFRGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
PTIDALLRHNGMAG
CHHHHHHHCCCCCC
>Mature Secondary Structure 
TNPLLDLSGLPSFDAIGPEHVGPAIDQLLAEAEAAVKAAEQVSPVCWDSFVTPLDDATE
CCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHH
RLWRAWGQVGHLQAVVNTPELREAYNCNLPKVSRFGSALAQNLALYAQYKALAQSPEAAH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSALAAKFSQNVLDATDAWSYVT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
CCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCHHHHHHHHHHHHHH
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKPHAQRDRAELEAFARDELGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVL
HCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHH
AGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGTLVGQFYLDLYAREGKRGGAWMD
HHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHH
DCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTQIGEL
HHHCCCCCCCCHHCCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHC
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
MFTVRQLEFALFDMQLHSTYDPSQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
YAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEVLARGGSRPAAENFRAFRGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
PTIDALLRHNGMAG
CHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]