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The map label for this gene is rmlD [H]

Identifier: 78049262

GI number: 78049262

Start: 4282297

End: 4283118

Strand: Reverse

Name: rmlD [H]

Synonym: XCV3706

Alternate gene names: 78049262

Gene position: 4283118-4282297 (Counterclockwise)

Preceding gene: 78049263

Following gene: 78049261

Centisome position: 82.71

GC content: 69.22

Gene sequence:

>822_bases
GTGGCAGCGACCCGTAGCGGGCAGCTACCTGACGGTACGACCTGCGAGACCGCGGATTTCGATGCGCCGGAAACATTGCC
TGGCTTGCTAGACCGCTTGCAGCCAAGTTGCGTCGTCAACGCAGCCGCCTATACGGCCGTCGATCGTGCCGAGCAGGAGC
GTGATGCCGCCTTCCGTGCCAATGCCGAGGCGCCGGCGGTCATCGCGCAATGGTGCGCGCGCGCCGGTGTGCCCCTGGTC
CATTACTCGACCGACTATGTCTTCGATGGACAGGGCACGCACCCCTATCGGCCGGACGATGCCACCGCGCCGCTCGGCGT
GTACGGGCAAAGCAAACTGGCCGGCGAGCAGGCAGTGCAGGCGGCCGGCGGCCGTCATCTGATCTTCCGCACTGCCTGGG
TCTACGCGGCGCATGGACACAATTTCCTGCGCACGATGCTGCGCGTGGGCGCCGAGCGCGACGTGCTGCGCGTGGTCGCC
GACCAGATCGGCACGCCAACGCCAGCGGCGTTAATCGCCGACATCACGGCGCACGCGCTGCGCCAGCCGGGCGAACCCTC
CGGCTTGTGGCATCTGACCGCCGCCGGGCAGACCACCTGGCACGGCTTCGCCGAAGCCATCTTCGCGCAGGCGCGCGCGC
GCGGCCTGCTCGCCCGTGCGCCGCGCGTGGAGGCGATCAGCACCGCCGACTATCCCACGCCGGCCACGCGCCCGGCCTAT
TCGCGACTGGATATCCACAGCCTGCAGGACACCTTCGGCGTCCGCCTGCCGGACTGGCAGGATGGACTGAGCCAGGTGCT
GGACACGCTCGCCCAACGATGA

Upstream 100 bases:

>100_bases
GCTTGCCAACCTTCCCAGCATGATCACGTTGGTGGTTGGTGCCAGCGGACAGGTCGGTACAGAGCTGTTGCGTGCACTTG
CAAGGGGCGGGGCAGAGGTG

Downstream 100 bases:

>100_bases
GCGTCGTCGGTGGTGCCATCGATCGGTGCGGCTTCAGCACCGACTCATAGCTTGCACTTCGCTTCGGCTACCATCAGGGT
TGATCCGCGCCGGACCGGCG

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MAATRSGQLPDGTTCETADFDAPETLPGLLDRLQPSCVVNAAAYTAVDRAEQERDAAFRANAEAPAVIAQWCARAGVPLV
HYSTDYVFDGQGTHPYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWVYAAHGHNFLRTMLRVGAERDVLRVVA
DQIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARARGLLARAPRVEAISTADYPTPATRPAY
SRLDIHSLQDTFGVRLPDWQDGLSQVLDTLAQR

Sequences:

>Translated_273_residues
MAATRSGQLPDGTTCETADFDAPETLPGLLDRLQPSCVVNAAAYTAVDRAEQERDAAFRANAEAPAVIAQWCARAGVPLV
HYSTDYVFDGQGTHPYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWVYAAHGHNFLRTMLRVGAERDVLRVVA
DQIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARARGLLARAPRVEAISTADYPTPATRPAY
SRLDIHSLQDTFGVRLPDWQDGLSQVLDTLAQR
>Mature_272_residues
AATRSGQLPDGTTCETADFDAPETLPGLLDRLQPSCVVNAAAYTAVDRAEQERDAAFRANAEAPAVIAQWCARAGVPLVH
YSTDYVFDGQGTHPYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWVYAAHGHNFLRTMLRVGAERDVLRVVAD
QIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARARGLLARAPRVEAISTADYPTPATRPAYS
RLDIHSLQDTFGVRLPDWQDGLSQVLDTLAQR

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=107, Percent_Identity=37.3831775700935, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI11034825, Length=91, Percent_Identity=41.7582417582418, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788352, Length=255, Percent_Identity=47.4509803921569, Blast_Score=241, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 29345; Mature: 29214

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATRSGQLPDGTTCETADFDAPETLPGLLDRLQPSCVVNAAAYTAVDRAEQERDAAFRA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NAEAPAVIAQWCARAGVPLVHYSTDYVFDGQGTHPYRPDDATAPLGVYGQSKLAGEQAVQ
CCCCHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AAGGRHLIFRTAWVYAAHGHNFLRTMLRVGAERDVLRVVADQIGTPTPAALIADITAHAL
HCCCCEEEEEHEEHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARARGLLARAPRVEAISTADYPTPATRPAY
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCH
SRLDIHSLQDTFGVRLPDWQDGLSQVLDTLAQR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AATRSGQLPDGTTCETADFDAPETLPGLLDRLQPSCVVNAAAYTAVDRAEQERDAAFRA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NAEAPAVIAQWCARAGVPLVHYSTDYVFDGQGTHPYRPDDATAPLGVYGQSKLAGEQAVQ
CCCCHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AAGGRHLIFRTAWVYAAHGHNFLRTMLRVGAERDVLRVVADQIGTPTPAALIADITAHAL
HCCCCEEEEEHEEHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARARGLLARAPRVEAISTADYPTPATRPAY
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCH
SRLDIHSLQDTFGVRLPDWQDGLSQVLDTLAQR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]