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The map label for this gene is iunH [H]

Identifier: 78049063

GI number: 78049063

Start: 4018695

End: 4019633

Strand: Reverse

Name: iunH [H]

Synonym: XCV3507

Alternate gene names: 78049063

Gene position: 4019633-4018695 (Counterclockwise)

Preceding gene: 78049064

Following gene: 78049062

Centisome position: 77.62

GC content: 67.63

Gene sequence:

>939_bases
ATGACTGACAAGATACCGCTGCTGATCGACACCGACCCTGGCGTGGACGACGCCTTGGCGCTGCTGATGGCCTTCAACGA
CACACGCCACGAGGTGGTCGGCCTGACCATCGCCGCCGGCAACGTGGGCCTGGAGCACACCGTGCGCAACGCCTTGAAGG
TCTGCGAGATCGCTGGCCGTACCGATGTGCCGGTCTACGCCGGCTGCCCGCAGCCGTTGCTGCACCCGTCGGTGGATGCG
GCGCACGTGCACGGTCTCGACGGATTCGGCGATGTGGGCCTGGCACCGGCCAAGCGCACTGCCGAGGCCGAACACGCCGC
GCTCGCCATCCTGCGTCTGTCGCACGAACACGCCGGCAAGCTGCTGCTGGTGGCGCTCGGTCCACTGACCAATCTTGCCC
TGGCGCTCACCCTGGACCCGACCCTGCCGCAGCGCGTGGCGCGGCTGGTGGTGATGGGCGGAGCGTTGACCGGGCACGGC
AATATCACCGCTGCGGCCGAGTTCAATATCGGATTCGACCCGGAAGCGGCGCATATCGTGTTCGGCGGTTTTCCGCAGTT
CGACGTGGCCGACTGGGAAGCCACCATTGCCCACGGCCTGCTGCACCGGGACGTGGAGCAATGGCTGGCGGCCGATTCTG
GCCGCGCCCGATTCTACGAGGAGATCTCGCGCAAGACCCGGCTGTGGTCCGAAGACAGCCGCGGCGAGTACTGGTATGCC
GCCGACGCGCTGGCGATGGCGTTCGCACTGCACCCGGAAGGCGCGCAGCGGCTGGAACAGCGCCCGGTCCATATCGAACT
GTCCGGTGCGCATACCCGTGGCATGACCCTGGTGGACTGGAACCGGCAGGGCGGGGCGCCCGACAATGCCAATCTGCTGC
TGGCCTATGACATCCAGCAGTTCTACGCGCTGGTCGGGGCCGCCCTGGCGGCGAACTGA

Upstream 100 bases:

>100_bases
GATTCGTAACAGCGTGGCGGCTGCGTGCTGCTGATTCGCGTGGCCGGCCGATCCTTGCGAAGATGCGGCAACGAATCCCG
AATGCCCAATCCCGAATCCC

Downstream 100 bases:

>100_bases
GGCGACCTTGCGCCGGCTGCCTGGGCGCAGCTATAATACCCGACTTATCCAGGCAGCCCGGCGCCAAGTCCATGAAAGAT
AACGTTCATCCCAACTACAA

Product: inosine-uridine preferring nucleoside hydrolase

Products: uracil; ribose; cytosine [C]

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTDKIPLLIDTDPGVDDALALLMAFNDTRHEVVGLTIAAGNVGLEHTVRNALKVCEIAGRTDVPVYAGCPQPLLHPSVDA
AHVHGLDGFGDVGLAPAKRTAEAEHAALAILRLSHEHAGKLLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHG
NITAAAEFNIGFDPEAAHIVFGGFPQFDVADWEATIAHGLLHRDVEQWLAADSGRARFYEEISRKTRLWSEDSRGEYWYA
ADALAMAFALHPEGAQRLEQRPVHIELSGAHTRGMTLVDWNRQGGAPDNANLLLAYDIQQFYALVGAALAAN

Sequences:

>Translated_312_residues
MTDKIPLLIDTDPGVDDALALLMAFNDTRHEVVGLTIAAGNVGLEHTVRNALKVCEIAGRTDVPVYAGCPQPLLHPSVDA
AHVHGLDGFGDVGLAPAKRTAEAEHAALAILRLSHEHAGKLLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHG
NITAAAEFNIGFDPEAAHIVFGGFPQFDVADWEATIAHGLLHRDVEQWLAADSGRARFYEEISRKTRLWSEDSRGEYWYA
ADALAMAFALHPEGAQRLEQRPVHIELSGAHTRGMTLVDWNRQGGAPDNANLLLAYDIQQFYALVGAALAAN
>Mature_311_residues
TDKIPLLIDTDPGVDDALALLMAFNDTRHEVVGLTIAAGNVGLEHTVRNALKVCEIAGRTDVPVYAGCPQPLLHPSVDAA
HVHGLDGFGDVGLAPAKRTAEAEHAALAILRLSHEHAGKLLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHGN
ITAAAEFNIGFDPEAAHIVFGGFPQFDVADWEATIAHGLLHRDVEQWLAADSGRARFYEEISRKTRLWSEDSRGEYWYAA
DALAMAFALHPEGAQRLEQRPVHIELSGAHTRGMTLVDWNRQGGAPDNANLLLAYDIQQFYALVGAALAAN

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786871, Length=307, Percent_Identity=34.2019543973941, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788486, Length=305, Percent_Identity=32.1311475409836, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786213, Length=307, Percent_Identity=33.2247557003257, Blast_Score=114, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI32565474, Length=290, Percent_Identity=31.0344827586207, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17565698, Length=295, Percent_Identity=30.8474576271186, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320608, Length=211, Percent_Identity=31.7535545023697, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24641839, Length=292, Percent_Identity=32.5342465753425, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24583915, Length=295, Percent_Identity=31.5254237288136, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24641837, Length=323, Percent_Identity=29.7213622291022, Blast_Score=107, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 33436; Mature: 33305

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKIPLLIDTDPGVDDALALLMAFNDTRHEVVGLTIAAGNVGLEHTVRNALKVCEIAGR
CCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCC
TDVPVYAGCPQPLLHPSVDAAHVHGLDGFGDVGLAPAKRTAEAEHAALAILRLSHEHAGK
CCCCEECCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCHHCHHHHHHEEEEEECCCCCCC
LLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHGNITAAAEFNIGFDPEAAHIV
EEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCCEEE
FGGFPQFDVADWEATIAHGLLHRDVEQWLAADSGRARFYEEISRKTRLWSEDSRGEYWYA
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEH
ADALAMAFALHPEGAQRLEQRPVHIELSGAHTRGMTLVDWNRQGGAPDNANLLLAYDIQQ
HHHHHHHHEECCCHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEECHHH
FYALVGAALAAN
HHHHHHHHHHCC
>Mature Secondary Structure 
TDKIPLLIDTDPGVDDALALLMAFNDTRHEVVGLTIAAGNVGLEHTVRNALKVCEIAGR
CCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCC
TDVPVYAGCPQPLLHPSVDAAHVHGLDGFGDVGLAPAKRTAEAEHAALAILRLSHEHAGK
CCCCEECCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCHHCHHHHHHEEEEEECCCCCCC
LLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHGNITAAAEFNIGFDPEAAHIV
EEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCCEEE
FGGFPQFDVADWEATIAHGLLHRDVEQWLAADSGRARFYEEISRKTRLWSEDSRGEYWYA
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEH
ADALAMAFALHPEGAQRLEQRPVHIELSGAHTRGMTLVDWNRQGGAPDNANLLLAYDIQQ
HHHHHHHHEECCCHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEECHHH
FYALVGAALAAN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine; H2O; cytidine [C]

Specific reaction: uridine + H2O = uracil + ribose cytidine + H2O = cytosine + ribose [C]

General reaction: Pyrimidine-specific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA