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The map label for this gene is sucD [H]

Identifier: 78048904

GI number: 78048904

Start: 3832767

End: 3833642

Strand: Reverse

Name: sucD [H]

Synonym: XCV3348

Alternate gene names: 78048904

Gene position: 3833642-3832767 (Counterclockwise)

Preceding gene: 78048905

Following gene: 78048903

Centisome position: 74.03

GC content: 65.07

Gene sequence:

>876_bases
ATGTCCGTTTTGATTAACAAGAACACCAAGGTGATCGTGCAGGGCTTTACCGGCCAGCAGGGCACCTTCCACGCCACTCA
GATGGTCGAGTACGGCACCCAGGTCGTCGGCGGCGTGACGCCCGGCAAGGGCGGCACCACCCACATCAATCTGCCGGTGT
TCAACACCGTGGCCGATGCGGTCCAGGCCACCGGCGCCGACGCCTCGGTGATCTACGTGCCGCCGCCGTACGCGGCCGAT
GCGATTCTGGAAGCGGCTGCGGCCGGCATCAAGGTCATCGTCTGCATCACCGAGGGCATCCCGGTGCTGGACATGCTGCG
CGTCAAGAACGTGCTGACCCGTTCGCATCCGGACACCGTGCTGATCGGGCCGAACTGCCCCGGCGTGATTACCCCGGGCG
AGTGCAAGATCGGCATCATGCCGGGCCACATCCACAAGCCGGGCAAGATCGGCATCGTGTCGCGTTCGGGCACGCTGACC
TATGAAGCGGTCAAGCAGACCACCGAAGTGGGCCTGGGCCAGAGCACCTGCATCGGCATCGGTGGCGACCCGATCAACGG
CCTGAACTTCGTCGACTGCTTCAAGCTGTTCAACGAAGACCCGCAGACCGAAGGCATCATCATGGTGGGTGAAATCGGTG
GCGACGCCGAGGAAGCCGGTGCCGAGTACATCAAGAACCACGTCAAGAAGCCGGTTGTCGGCTTCATCGCCGGTGCCTCC
GCGCCGGCCGGCAAGCGCATGGGCCATGCCGGTGCGATCGCGTCCGGTGGCAAGGGCACGGCCGAAGGCAAGTTCGCGGC
GATGGAAGCCGCCGGCGTCAAGACCGTCCGCTCGCCGGGCGATCTGGGTGCGGCGATTGCGGCGCTGGTGAAGTAA

Upstream 100 bases:

>100_bases
CATGGCCATCATCCCGGCCGACAACATCAACGACGGCGCCAAGAAAGTCGTTGAAGCTGTCAAGAACGCCGCCTGATCCA
CGATACCGAAGGAACTATCC

Downstream 100 bases:

>100_bases
GTCTTACCAGTGTGGTGTCGCAGAAAGCCGCCTTCGGGCGGCTTTCTGCGTTTACGGGGATGCCTGATGCAGATAGCAGG
GATTGCGCACTGCACGACGC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSVLINKNTKVIVQGFTGQQGTFHATQMVEYGTQVVGGVTPGKGGTTHINLPVFNTVADAVQATGADASVIYVPPPYAAD
AILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSHPDTVLIGPNCPGVITPGECKIGIMPGHIHKPGKIGIVSRSGTLT
YEAVKQTTEVGLGQSTCIGIGGDPINGLNFVDCFKLFNEDPQTEGIIMVGEIGGDAEEAGAEYIKNHVKKPVVGFIAGAS
APAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVKTVRSPGDLGAAIAALVK

Sequences:

>Translated_291_residues
MSVLINKNTKVIVQGFTGQQGTFHATQMVEYGTQVVGGVTPGKGGTTHINLPVFNTVADAVQATGADASVIYVPPPYAAD
AILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSHPDTVLIGPNCPGVITPGECKIGIMPGHIHKPGKIGIVSRSGTLT
YEAVKQTTEVGLGQSTCIGIGGDPINGLNFVDCFKLFNEDPQTEGIIMVGEIGGDAEEAGAEYIKNHVKKPVVGFIAGAS
APAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVKTVRSPGDLGAAIAALVK
>Mature_290_residues
SVLINKNTKVIVQGFTGQQGTFHATQMVEYGTQVVGGVTPGKGGTTHINLPVFNTVADAVQATGADASVIYVPPPYAADA
ILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSHPDTVLIGPNCPGVITPGECKIGIMPGHIHKPGKIGIVSRSGTLTY
EAVKQTTEVGLGQSTCIGIGGDPINGLNFVDCFKLFNEDPQTEGIIMVGEIGGDAEEAGAEYIKNHVKKPVVGFIAGASA
PAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVKTVRSPGDLGAAIAALVK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=288, Percent_Identity=65.9722222222222, Blast_Score=328, Evalue=2e-90,
Organism=Homo sapiens, GI38569423, Length=315, Percent_Identity=29.8412698412698, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI38569421, Length=315, Percent_Identity=29.8412698412698, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786949, Length=291, Percent_Identity=71.8213058419244, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17550194, Length=290, Percent_Identity=63.1034482758621, Blast_Score=343, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17553126, Length=289, Percent_Identity=63.6678200692042, Blast_Score=340, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI17551266, Length=310, Percent_Identity=30.3225806451613, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17557344, Length=257, Percent_Identity=30.7392996108949, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=293, Percent_Identity=54.6075085324232, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21356559, Length=289, Percent_Identity=56.7474048442907, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI28574296, Length=294, Percent_Identity=60.8843537414966, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI281363477, Length=310, Percent_Identity=28.3870967741935, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363475, Length=310, Percent_Identity=28.3870967741935, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363473, Length=310, Percent_Identity=28.3870967741935, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 29592; Mature: 29460

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLINKNTKVIVQGFTGQQGTFHATQMVEYGTQVVGGVTPGKGGTTHINLPVFNTVADA
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHH
VQATGADASVIYVPPPYAADAILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSHPDTV
HHHCCCCCEEEEECCCCHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEE
LIGPNCPGVITPGECKIGIMPGHIHKPGKIGIVSRSGTLTYEAVKQTTEVGLGQSTCIGI
EECCCCCCEECCCCEEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEEEC
GGDPINGLNFVDCFKLFNEDPQTEGIIMVGEIGGDAEEAGAEYIKNHVKKPVVGFIAGAS
CCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCC
APAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVKTVRSPGDLGAAIAALVK
CCCCCCCCCCCCCCCCCCCCCCCCEEEEHHCCCCEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
SVLINKNTKVIVQGFTGQQGTFHATQMVEYGTQVVGGVTPGKGGTTHINLPVFNTVADA
EEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHH
VQATGADASVIYVPPPYAADAILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSHPDTV
HHHCCCCCEEEEECCCCHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEE
LIGPNCPGVITPGECKIGIMPGHIHKPGKIGIVSRSGTLTYEAVKQTTEVGLGQSTCIGI
EECCCCCCEECCCCEEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEEEC
GGDPINGLNFVDCFKLFNEDPQTEGIIMVGEIGGDAEEAGAEYIKNHVKKPVVGFIAGAS
CCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCC
APAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVKTVRSPGDLGAAIAALVK
CCCCCCCCCCCCCCCCCCCCCCCCEEEEHHCCCCEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]