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The map label for this gene is gabP [H]

Identifier: 78048687

GI number: 78048687

Start: 3549737

End: 3551125

Strand: Reverse

Name: gabP [H]

Synonym: XCV3131

Alternate gene names: 78048687

Gene position: 3551125-3549737 (Counterclockwise)

Preceding gene: 78048688

Following gene: 78048686

Centisome position: 68.57

GC content: 66.95

Gene sequence:

>1389_bases
ATGCCGCTTCCGACCGATTCCGTTGCTGAGACCGCTGCGCCCGCCGCGCCTGCATTGCGCCATGCGCTGAAGCCGCGGCA
ATTGATGATGATGGGCCTGGGCACGGCGATCGGCGCCGGGCTGTTTCTGGGATCCGGTGTAGGCATCCACGCGGCCGGTC
CGGCGGTACTGATCTCGTATCTGATTGCCGGGGCGTTGGTCATCATCGTGATGAACGCGCTGGGCGAAATGGCCGCCGCC
AAGCCGGCCAGCGGGGCATTCTCGGTGTACGCCGCCGATGCGATGGGCCCGACGGCCGGCGCCACCGTGGGCTGGCTGTG
GTGGTTTCAGGTGGTGGTGGTGATTGCGGCCGAGGCGGTAGGTGCCGCCGGGCTGCTGGCCACGGTCTGGCCGGCGTTGC
CGGTGCCGTTGCTGGCGTTGCTGTTCATGGCCACGTTCACTGCGATCAATCTGCTCGGCGTGCGCAACTTTGGCGAGTTC
GAATTCTGGTTCGCCATTCTGAAAGTGCTGGCGATCGTGGTGTTCCTGCTGATCGGCGTGGCGTTGCTGGCGGGCTGGTT
GCCCGGAGTGGCATCGCCCGGGCTGTCCAACTTCACCCAGAACGGCGGCTTTGCGCCCAAGGGCCTGGCCGGTATCGGCT
CGGCGTTGCTGGTGGTGGTGTTTGCCTTCGGCGGCACCGAAATCGTGGCGGTGGCCGCCGCGGAAACCGCCGACCCGGGA
CGTAGCCTGGCGCGCACCATTCGCACTGTCGCCTGGCGCATCCTGGTGTTCTATATCGGGTCGATCAGCGTGATCGTGGC
GGTGGTGCCGTGGACCAGCGCCGCGCTCAGCTCGCCGTTCGCGGCCGTGCTGGACGTGGCACGCATTCCCGGTGCCGCCA
CGGCGATCACCCTGGTGGCGGTGGTCGCGCTGCTGTCGGCGCTCAACGCTAATCTGTACGGTGCCTCGCGGATGATCTTC
TCGCTGGCCCAGCGCGGCGAAGCGCCGCGGTTGCTGGCCAGGACCAGCGGCGAGCAAGTGCCGCTGGTGGCGGTGATCGC
CAGCGTGTTGTTCGGCTTCGCCGCCGCAGCGCTGGAGTTGCTGTATCCGAACAAGGTGTTGCCAATGCTGCTCAACATCG
TCGGCGCCACTTGCCTGCTGGTGTGGACGATCTCGCTGGTATCGCAACTGATCTTGCGCGCCCGCGCGGACCGTGCCGGC
CTTGCGTTGCCGTTCCGCATGCGCGGCTATCCGTTTCTGACCGTGCTGGCGCTGGTCATCCTGGGCGTGATCTTCGTGTT
GTTGGCCTCTTCGGCCGATACGCGCGCGCAATTCCTCTCGATGGTCGCGCTGACCGCAGTCATCGCAGCGGTCAGCGAAG
TTGCGCGGCGCCTGCGTGCGCGGATGTGA

Upstream 100 bases:

>100_bases
TCGCGAGACATCGCCACTCCTTCCCCGGGCTGGAGTCAAGAGGCGCGGCAGGCGCTGCGACGCGGTATCGTGTCGCGATT
CCATCCATGCAAGCCTGTCC

Downstream 100 bases:

>100_bases
GGAATTGGAAGCGTGGCAGTGTGTTGGTGCGTTGTGTGCGCTGGCGGGCGTGTCAGCTGTAACCGGCGGCCAGCGCTCAT
GACGCGAGTGCAACCGGCAA

Product: amino acid transporter family protein

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MPLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISYLIAGALVIIVMNALGEMAAA
KPASGAFSVYAADAMGPTAGATVGWLWWFQVVVVIAAEAVGAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEF
EFWFAILKVLAIVVFLLIGVALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLDVARIPGAATAITLVAVVALLSALNANLYGASRMIF
SLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAG
LALPFRMRGYPFLTVLALVILGVIFVLLASSADTRAQFLSMVALTAVIAAVSEVARRLRARM

Sequences:

>Translated_462_residues
MPLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISYLIAGALVIIVMNALGEMAAA
KPASGAFSVYAADAMGPTAGATVGWLWWFQVVVVIAAEAVGAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEF
EFWFAILKVLAIVVFLLIGVALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLDVARIPGAATAITLVAVVALLSALNANLYGASRMIF
SLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAG
LALPFRMRGYPFLTVLALVILGVIFVLLASSADTRAQFLSMVALTAVIAAVSEVARRLRARM
>Mature_461_residues
PLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISYLIAGALVIIVMNALGEMAAAK
PASGAFSVYAADAMGPTAGATVGWLWWFQVVVVIAAEAVGAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEFE
FWFAILKVLAIVVFLLIGVALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPGR
SLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLDVARIPGAATAITLVAVVALLSALNANLYGASRMIFS
LAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGL
ALPFRMRGYPFLTVLALVILGVIFVLLASSADTRAQFLSMVALTAVIAAVSEVARRLRARM

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=428, Percent_Identity=23.3644859813084, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI181337167, Length=406, Percent_Identity=26.8472906403941, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI114326544, Length=426, Percent_Identity=23.7089201877934, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI114326550, Length=426, Percent_Identity=23.7089201877934, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI110347453, Length=370, Percent_Identity=25.1351351351351, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI258645169, Length=435, Percent_Identity=22.9885057471264, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258614005, Length=436, Percent_Identity=22.7064220183486, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614003, Length=436, Percent_Identity=22.7064220183486, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789017, Length=408, Percent_Identity=41.421568627451, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.995337995338, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786302, Length=415, Percent_Identity=34.4578313253012, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI87081708, Length=435, Percent_Identity=37.0114942528736, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1786602, Length=425, Percent_Identity=35.5294117647059, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1790653, Length=437, Percent_Identity=33.1807780320366, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1788480, Length=435, Percent_Identity=34.7126436781609, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI48994972, Length=444, Percent_Identity=34.009009009009, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87081915, Length=423, Percent_Identity=33.806146572104, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87081869, Length=237, Percent_Identity=26.5822784810127, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=419, Percent_Identity=24.8210023866348, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=32.8798185941043, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324061, Length=448, Percent_Identity=31.25, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=446, Percent_Identity=29.372197309417, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=411, Percent_Identity=31.1435523114355, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=442, Percent_Identity=30.7692307692308, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=371, Percent_Identity=31.8059299191375, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=413, Percent_Identity=27.6029055690073, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=438, Percent_Identity=29.6803652968037, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=411, Percent_Identity=28.7104622871046, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=402, Percent_Identity=26.865671641791, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324990, Length=411, Percent_Identity=28.7104622871046, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=416, Percent_Identity=26.9230769230769, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=408, Percent_Identity=26.7156862745098, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320251, Length=450, Percent_Identity=26.6666666666667, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=354, Percent_Identity=29.3785310734463, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=27.7078085642317, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319608, Length=452, Percent_Identity=24.7787610619469, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=22.3790322580645, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24668806, Length=422, Percent_Identity=24.4075829383886, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356285, Length=422, Percent_Identity=24.4075829383886, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24668802, Length=422, Percent_Identity=24.4075829383886, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221512776, Length=411, Percent_Identity=24.330900243309, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24666159, Length=402, Percent_Identity=24.3781094527363, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47612; Mature: 47480

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISY
CCCCCCHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LIAGALVIIVMNALGEMAAAKPASGAFSVYAADAMGPTAGATVGWLWWFQVVVVIAAEAV
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEFEFWFAILKVLAIVVFLLIGV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLDVARIPGAATAITLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHH
VVALLSALNANLYGASRMIFSLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALEL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGLALPFRMRGYPFLTVLALVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHH
LGVIFVLLASSADTRAQFLSMVALTAVIAAVSEVARRLRARM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISY
CCCCCHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LIAGALVIIVMNALGEMAAAKPASGAFSVYAADAMGPTAGATVGWLWWFQVVVVIAAEAV
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAAGLLATVWPALPVPLLALLFMATFTAINLLGVRNFGEFEFWFAILKVLAIVVFLLIGV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLDVARIPGAATAITLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHH
VVALLSALNANLYGASRMIFSLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALEL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGLALPFRMRGYPFLTVLALVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHH
LGVIFVLLASSADTRAQFLSMVALTAVIAAVSEVARRLRARM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]