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The map label for this gene is creC [H]

Identifier: 78048570

GI number: 78048570

Start: 3427361

End: 3428809

Strand: Reverse

Name: creC [H]

Synonym: XCV3014

Alternate gene names: 78048570

Gene position: 3428809-3427361 (Counterclockwise)

Preceding gene: 162138532

Following gene: 78048568

Centisome position: 66.21

GC content: 66.53

Gene sequence:

>1449_bases
ATGCGGCTTGGTCTCAAGCTGTTCCTGGGCTTCTTCCTGATCGTGGGCCTGGCCGCGTTCTTCGTGATGCGCGTGTTCGT
CAACGAGGTCAAGCCAGGGGTGCGCCAGGCGATGGAATCCACGCTGGTGGATGCGGCCAATGTGCTGGCGGAAATGGCCA
GTGGCGAGTTGGCTGCCGGCACGCTTGCCGATGGCCGCTTCGCGCGCAACGTGGCCAGGGCCCAGCAGCGCGACCCCAAG
GCGTGGGTATGGCGCTTTCGCAAGAACACGGTGGATTACCGCGTGACCGTCACCGATGCGCGCGGCGTGGTGGTGTTCGA
TTCGCTGGGCCGCGACGTGGGCCGCGACAACTCGCGCTGGAACGATGTCTATCGCACGCTGCGCGGCGAATATGGCGCGC
GTTCCAGCCCGGACATCGATGGCGACCCTGCCGCCACGGTGATGCATGTGGCCGCGCCGATCTACGCACCGGACGACCCC
GGCAAACTGATCGGCGTGCTGACCCTGGCGCAGCCCAATCGCAGCATCGACCCGTTTATCGAAGCCAGCCAGCGCAACAT
CCTGCAGCGCGGCGCCTGGTTGATCGGCATTTCCGTGTTGATCGGCATCTTGATGACCTGGTGGTTGATGCGTGGCATCG
GCCGGCTCAATCGCTATGCGCAGGCGGTGAGCGCCGGCATCCCGGTACCGCCGCCCAAACCGCGTGGCGATGAAATCGGC
GATCTGGGCCAGGCGCTGGAAAGCATGCGTCGCAAGCTGGAAGGCAAGGCCTACGTGGAGCAGTACGTGCAGTCGCTGAC
GCACGAGATGAAAAGCCCGCTGGCGGCCATTCGCGGTGCCTCGGAGTTGTTGACCGAGCCACTGCCGGAGGCCGACCGCC
AGCACTTCGTTGCCACCATCCGCGCGCAGGAACACCGGCTCACCGAAACCATCGACAAGCTGCTGGCACTGGCCGAGGTG
GAGCAGCACGGCTGGCTGCAGAAGCGCGAGCCCATCGGTATTGATGGGCTGCTGCAGGCTGCGGCGGACGCGGTGGCGCT
GCGTGCAGCGGCGGCGGGCATCACCGTGGAGGTGGACGCAGGGGCTGGCGCGCCAGGCGATCACCACGTACTGGGCGATG
GGTTTCTGCTCAGGCAGGCACTGATCAATCTGCTCGAAAACGCCATCGCGTTTTCGACGCAAGACAGCCATGTGCGCCTG
CAGGCGCGGCTGCGCGACGGACACTGGGAGTTGCTGGTTGAAGACCGCGGCAGTGGCGTGCCGGATTACGCGCTCGAGCG
CGTCTTCGAGCGGTTCTATTCGCTGGCACGCCCGCAGACCGGCCAGCGCAGCTCCGGTCTCGGCTTGCCGTTCGTGCGCG
AGGTTGCGCGCCTGCATGGCGGGGACGTGATGCTGGGCAACCGCGATGGTGGCGGTGCGCGTGCGGTGTTGCGCCTGCCG
ATCGGCTGA

Upstream 100 bases:

>100_bases
GGCCGACCCGATCCGCACCCACCGGGGCCTTGGCTACGCGCTGGAGGTATAGGCATGCGCCGGCACGCATTTGGTGAACT
GAGCGAGGCCGCGGGCTGAC

Downstream 100 bases:

>100_bases
GTCGCTGCAGGCCGTTGTCGCGGCTGGTTGGCGCCGGTGGCAGCCGCGCGTTCAAGGCTGCGGCATGCGCCAGGGCACAT
GCCGCGCCTGCATCACTCAG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASGELAAGTLADGRFARNVARAQQRDPK
AWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPDIDGDPAATVMHVAAPIYAPDDP
GKLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISVLIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLTEPLPEADRQHFVATIRAQEHRLTETIDKLLALAEV
EQHGWLQKREPIGIDGLLQAAADAVALRAAAAGITVEVDAGAGAPGDHHVLGDGFLLRQALINLLENAIAFSTQDSHVRL
QARLRDGHWELLVEDRGSGVPDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVMLGNRDGGGARAVLRLP
IG

Sequences:

>Translated_482_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASGELAAGTLADGRFARNVARAQQRDPK
AWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPDIDGDPAATVMHVAAPIYAPDDP
GKLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISVLIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLTEPLPEADRQHFVATIRAQEHRLTETIDKLLALAEV
EQHGWLQKREPIGIDGLLQAAADAVALRAAAAGITVEVDAGAGAPGDHHVLGDGFLLRQALINLLENAIAFSTQDSHVRL
QARLRDGHWELLVEDRGSGVPDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVMLGNRDGGGARAVLRLP
IG
>Mature_482_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASGELAAGTLADGRFARNVARAQQRDPK
AWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPDIDGDPAATVMHVAAPIYAPDDP
GKLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISVLIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLTEPLPEADRQHFVATIRAQEHRLTETIDKLLALAEV
EQHGWLQKREPIGIDGLLQAAADAVALRAAAAGITVEVDAGAGAPGDHHVLGDGFLLRQALINLLENAIAFSTQDSHVRL
QARLRDGHWELLVEDRGSGVPDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVMLGNRDGGGARAVLRLP
IG

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=479, Percent_Identity=46.972860125261, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=27.8761061946903, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788393, Length=254, Percent_Identity=28.3464566929134, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=26.457399103139, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789403, Length=295, Percent_Identity=30.5084745762712, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=26.8774703557312, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=26.5822784810127, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=24.2914979757085, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=314, Percent_Identity=25.1592356687898, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788279, Length=263, Percent_Identity=27.7566539923954, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=417, Percent_Identity=22.3021582733813, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87081816, Length=285, Percent_Identity=25.9649122807018, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790551, Length=305, Percent_Identity=26.2295081967213, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=255, Percent_Identity=22.7450980392157, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=23.5294117647059, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=25.1101321585903, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52698; Mature: 52698

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASGELAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TLADGRFARNVARAQQRDPKAWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRW
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCEEEEHHHCCCCCCCCCHH
NDVYRTLRGEYGARSSPDIDGDPAATVMHVAAPIYAPDDPGKLIGVLTLAQPNRSIDPFI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHH
EASQRNILQRGAWLIGISVLIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLTEPLPEADRQHFVATI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHH
RAQEHRLTETIDKLLALAEVEQHGWLQKREPIGIDGLLQAAADAVALRAAAAGITVEVDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEC
GAGAPGDHHVLGDGFLLRQALINLLENAIAFSTQDSHVRLQARLRDGHWELLVEDRGSGV
CCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCC
PDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVMLGNRDGGGARAVLRLP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEECC
IG
CC
>Mature Secondary Structure
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASGELAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TLADGRFARNVARAQQRDPKAWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRW
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCEEEEHHHCCCCCCCCCHH
NDVYRTLRGEYGARSSPDIDGDPAATVMHVAAPIYAPDDPGKLIGVLTLAQPNRSIDPFI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHH
EASQRNILQRGAWLIGISVLIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLTEPLPEADRQHFVATI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHH
RAQEHRLTETIDKLLALAEVEQHGWLQKREPIGIDGLLQAAADAVALRAAAAGITVEVDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEC
GAGAPGDHHVLGDGFLLRQALINLLENAIAFSTQDSHVRLQARLRDGHWELLVEDRGSGV
CCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCC
PDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVMLGNRDGGGARAVLRLP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEECC
IG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]