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The map label for this gene is holA [H]

Identifier: 78048491

GI number: 78048491

Start: 3337667

End: 3338698

Strand: Reverse

Name: holA [H]

Synonym: XCV2935

Alternate gene names: 78048491

Gene position: 3338698-3337667 (Counterclockwise)

Preceding gene: 78048492

Following gene: 78048490

Centisome position: 64.47

GC content: 69.67

Gene sequence:

>1032_bases
GTGATGGAACTTCGCCCAGAGCAGCTGGCCGGCCAGTCCAGCCAGCCCTTGCAGCCGGTGTATCTGATCGCCGGCCCCGA
GACCTTGCGTGTGCTTGAGGCCGCCGATGCGGTGCGCGCACGCGCGCGCGCCGAAGGCATCGGCGAACGCGAAGTATTCG
ATGCCGATGGCCGCGAGTTCGACTGGAACCAGCTTGACGCCAGCTTCAATGCGCCCAGCCTGTTCAGTCCGCGCCGCCTG
GTCGAAGTGCGCCTGCCCAGCGGCAAGCCCGGCAAGGACGGGGCCGAGGTCATCACCCGCTTCTGCGCCAACCCGCCGCC
GGACGTGGTGCTGCTGATCACCGCCAACGACTGGAGCAAGGCGCATCACGGCAAGTGGGCGGAGGCGGTCGGTCGCATCG
GCACCATCGCGGTGGCCTGGGCGATCAAACCGCACGAACTGTCCGACTGGATCGAGCGCCGCCTGCGCGCGCACGGCCTG
CGCGCCGATGCCGCTGCCGTGCAGCGCCTGAGCGAGCGGGTGGAAGGCAACCTGCTCGCCGCCGCGCAGGAAATCGACAA
GCTCGCCCTGTTGGCCGACGGCAAGACGCTGGATCTGGAGGCGATGGAATCGCTGGTTGCCGATGCCGCGCGCTACGACG
TGTTCCGGCTGGCCGAAACCACGTTGTCCGGGCAGCCGGCCGCGGTGATCCGCATGCTTGCCGGCCTGCGCGGCGAAGGC
GAGGCGGTCGCCGCGCTGATGCCGATCCTGATCAAGGAACTGCTGCGCACCGCGTCGCTGGCGAAGGTGCAGGCCAACGG
CGGCAACCTGGCCGCCGAAATGAAGGCGCAAGGGCTGTGGGAATCGCGCCAGGCGCCCTTCAAGCGCGCGCTGCAGCGTC
ACCCCGAACCGCACCGCTGGGAACGCTTCGTCGCCGAAGCCGGGCTGGTCGATCGCATGGCCAAGGGCCGCGCCGACGGC
GATGCCTGGGTTGGTCTGGAACGCCTGCTGGTGGCCGTGGCCGAAGCCCGCGCGGTGAGATTGTTGGCGTGA

Upstream 100 bases:

>100_bases
ACGGCGCCAGCGCAGCCGACCACGACACCCGAATCCAGCGTGCCGGCCTCGTTGCCGCCCGCGCCCACGTCGGGCAACTG
AGCCGCGCCCCGCGTTTTCG

Downstream 100 bases:

>100_bases
AGGCCAGTGACGCCGGGACCCGGGACCCGGGACCGGGGAGCCGGGAAGGGCAGGGTGACCGGCAGCGAGCCCATTCCGAC
CAGCTTGCGCAGGCCAGCCC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MMELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFDWNQLDASFNAPSLFSPRRL
VEVRLPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKAHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGL
RADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTLSGQPAAVIRMLAGLRGEG
EAVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWERFVAEAGLVDRMAKGRADG
DAWVGLERLLVAVAEARAVRLLA

Sequences:

>Translated_343_residues
MMELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFDWNQLDASFNAPSLFSPRRL
VEVRLPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKAHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGL
RADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTLSGQPAAVIRMLAGLRGEG
EAVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWERFVAEAGLVDRMAKGRADG
DAWVGLERLLVAVAEARAVRLLA
>Mature_343_residues
MMELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFDWNQLDASFNAPSLFSPRRL
VEVRLPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKAHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGL
RADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTLSGQPAAVIRMLAGLRGEG
EAVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWERFVAEAGLVDRMAKGRADG
DAWVGLERLLVAVAEARAVRLLA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=295, Percent_Identity=32.5423728813559, Blast_Score=111, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37402; Mature: 37402

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREF
CCCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
DWNQLDASFNAPSLFSPRRLVEVRLPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSK
CHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCH
AHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGLRADAAAVQRLSERVEGNLLA
HHCCHHHHHHCCHHEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
AAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTLSGQPAAVIRMLAGLRGEG
HHHHHHHHHEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
EAVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRW
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHCCHHHCCCHHHHHHHHCCCHHHH
ERFVAEAGLVDRMAKGRADGDAWVGLERLLVAVAEARAVRLLA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREF
CCCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
DWNQLDASFNAPSLFSPRRLVEVRLPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSK
CHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCH
AHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGLRADAAAVQRLSERVEGNLLA
HHCCHHHHHHCCHHEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
AAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTLSGQPAAVIRMLAGLRGEG
HHHHHHHHHEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
EAVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRW
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHCCHHHCCCHHHHHHHHCCCHHHH
ERFVAEAGLVDRMAKGRADGDAWVGLERLLVAVAEARAVRLLA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]