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The map label for this gene is argG [H]

Identifier: 78048106

GI number: 78048106

Start: 2877639

End: 2878874

Strand: Reverse

Name: argG [H]

Synonym: XCV2550

Alternate gene names: 78048106

Gene position: 2878874-2877639 (Counterclockwise)

Preceding gene: 78048107

Following gene: 78048105

Centisome position: 55.59

GC content: 63.59

Gene sequence:

>1236_bases
ATGAGCGCTGCTTCCACCAATCCCGAATCCCGAATCCCGACTCCCGGCACCAAGGACATCGTTCTCGCGTTTTCCGGTGG
TCTGGACACCAGCTTCTGCATTCCGTATCTGCAGGAGCGCGGCTATGCGGTGCACACCGTGTTTGCCGACACCGGTGGTG
TGGATGCCGAAGAGCGTGAGTTCATCGAGAAGCGCGCCGCCGAATTGGGCGCGGCCAGCCACGTCACCGTGGACGGTGGC
CCGGCAATCTGGGAAGGCTTCGTCAAGCCGTTCGTGTGGGCGGGCGAGGGGTACCAGGGCCAGTACCCGTTGCTGGTGTC
CGACCGTTACCTGATCGTGGATGCTGCGCTCAAGCGTGCCGAAGAGTTGGGCACACGCATCATTGCGCATGGTTGCACCG
GCATGGGCAACGATCAGGTGCGTTTCGACCTGGCAGTGAAGGCGCTGGGCGACTACCAGATCGTGGCGCCGATCCGCGAG
ATCCAGAAAGAGCACACCCAGACCCGCGCCTATGAGCAGAAGTATCTGGAAGCGCGTGGATTCGGCGTGCGTGCCAAACA
GCAGGCCTACACCATCAACGAGAACCTGCTGGGCCTGACCATGTCCGGCGGCGAGATCGATCGTTGGGAAGCGCCGGGCG
AGGGCGCGCGCGGCTGGTGCGCGCCGCGCAGTGCCTGGCCGAGCGAAGCGTTGACGGTGACGCTGAAGTTCGTCGAAGGC
GAAGCGGTGGAACTGGACGGTAAGCCGCTGCCGGGTGCCAAGATCCTGGCCAAGCTCAACACCTTGTTTGCGCAATACGG
CGTGGGCCGCGGCGTCTATACCGGCGACACCGTGATCGGTTTGAAGGGCCGCATCGTGTTCGAAGCGCCGGGCCTGATTT
CGCTGATCACCGCGCACCGTGCACTGGAAGATGCGGTGCTGACCAAGCAGCAGAACCGCTTCAAGCCGGACGTGGCGCGC
AAATGGGTGGAGCTGGTGTACGAAGGCTTCTATCACGACCCGCTCAAGAGCGATATCGAGGCGTTCCTGAAGTCCTCGCA
GTCCAAGGTCAATGGCGAGGTGACGCTGGAAACCCGCGGCGGCCGCGTCGATGCGGTGGCGGTACGCTCGCCGCACCTGC
TCAACACCAAGGGTGCGACCTACGCGCAATCGGCCGACTGGGGCGTGGAAGAAGCGGAAGGCTTCATCAAGCTGTTCGGG
ATGAGCTCGACGCTGTACGCGCAGGTCAACCGCTGA

Upstream 100 bases:

>100_bases
CATGGCGGCGCTTGCTTCGCAAGCGGGAATCGGGAATCGGGATTAGAGAATCGCAACAGCAACACCCTTGGCCCCCACAT
TTACGTACTAAGGAACAATG

Downstream 100 bases:

>100_bases
GCAAAAGCCCCTCTCCCCCGGGGAGAGGGGCTTGGGGTGCCGCAGAAACCTCCAAGATCGATCATGACGAACGCGTCGCC
ACGCGCCAGTCATGGGGAAC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSAASTNPESRIPTPGTKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEEREFIEKRAAELGAASHVTVDGG
PAIWEGFVKPFVWAGEGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIRE
IQKEHTQTRAYEQKYLEARGFGVRAKQQAYTINENLLGLTMSGGEIDRWEAPGEGARGWCAPRSAWPSEALTVTLKFVEG
EAVELDGKPLPGAKILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLITAHRALEDAVLTKQQNRFKPDVAR
KWVELVYEGFYHDPLKSDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLLNTKGATYAQSADWGVEEAEGFIKLFG
MSSTLYAQVNR

Sequences:

>Translated_411_residues
MSAASTNPESRIPTPGTKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEEREFIEKRAAELGAASHVTVDGG
PAIWEGFVKPFVWAGEGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIRE
IQKEHTQTRAYEQKYLEARGFGVRAKQQAYTINENLLGLTMSGGEIDRWEAPGEGARGWCAPRSAWPSEALTVTLKFVEG
EAVELDGKPLPGAKILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLITAHRALEDAVLTKQQNRFKPDVAR
KWVELVYEGFYHDPLKSDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLLNTKGATYAQSADWGVEEAEGFIKLFG
MSSTLYAQVNR
>Mature_410_residues
SAASTNPESRIPTPGTKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEEREFIEKRAAELGAASHVTVDGGP
AIWEGFVKPFVWAGEGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIREI
QKEHTQTRAYEQKYLEARGFGVRAKQQAYTINENLLGLTMSGGEIDRWEAPGEGARGWCAPRSAWPSEALTVTLKFVEGE
AVELDGKPLPGAKILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLITAHRALEDAVLTKQQNRFKPDVARK
WVELVYEGFYHDPLKSDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLLNTKGATYAQSADWGVEEAEGFIKLFGM
SSTLYAQVNR

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=404, Percent_Identity=27.2277227722772, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI16950633, Length=404, Percent_Identity=27.2277227722772, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1789563, Length=374, Percent_Identity=26.7379679144385, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324514, Length=360, Percent_Identity=29.1666666666667, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358151, Length=396, Percent_Identity=30.050505050505, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44821; Mature: 44690

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAASTNPESRIPTPGTKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERE
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
FIEKRAAELGAASHVTVDGGPAIWEGFVKPFVWAGEGYQGQYPLLVSDRYLIVDAALKRA
HHHHHHHHCCCCCEEEECCCHHHHHHHHCCEEECCCCCCCCCCEEECCCEEEEHHHHHHH
EELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIREIQKEHTQTRAYEQKYLEARG
HHHHHEEEECCCCCCCCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
FGVRAKQQAYTINENLLGLTMSGGEIDRWEAPGEGARGWCAPRSAWPSEALTVTLKFVEG
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC
EAVELDGKPLPGAKILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLITAHR
CEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEECCCEEEEECCEEEEECCCHHHHHHHHH
ALEDAVLTKQQNRFKPDVARKWVELVYEGFYHDPLKSDIEAFLKSSQSKVNGEVTLETRG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
GRVDAVAVRSPHLLNTKGATYAQSADWGVEEAEGFIKLFGMSSTLYAQVNR
CEEEEEEECCCCEECCCCCCCCCCCCCCHHHHCCEEEEEECCCEEEEEECC
>Mature Secondary Structure 
SAASTNPESRIPTPGTKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERE
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
FIEKRAAELGAASHVTVDGGPAIWEGFVKPFVWAGEGYQGQYPLLVSDRYLIVDAALKRA
HHHHHHHHCCCCCEEEECCCHHHHHHHHCCEEECCCCCCCCCCEEECCCEEEEHHHHHHH
EELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIREIQKEHTQTRAYEQKYLEARG
HHHHHEEEECCCCCCCCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
FGVRAKQQAYTINENLLGLTMSGGEIDRWEAPGEGARGWCAPRSAWPSEALTVTLKFVEG
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC
EAVELDGKPLPGAKILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLITAHR
CEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEECCCEEEEECCEEEEECCCHHHHHHHHH
ALEDAVLTKQQNRFKPDVARKWVELVYEGFYHDPLKSDIEAFLKSSQSKVNGEVTLETRG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
GRVDAVAVRSPHLLNTKGATYAQSADWGVEEAEGFIKLFGMSSTLYAQVNR
CEEEEEEECCCCEECCCCCCCCCCCCCCHHHHCCEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]