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The map label for this gene is guaA [H]

Identifier: 78048041

GI number: 78048041

Start: 2803985

End: 2805550

Strand: Reverse

Name: guaA [H]

Synonym: XCV2485

Alternate gene names: 78048041

Gene position: 2805550-2803985 (Counterclockwise)

Preceding gene: 78048042

Following gene: 78048040

Centisome position: 54.18

GC content: 64.11

Gene sequence:

>1566_bases
ATGACCAACATCCATACCGACAAGATCCTCATCCTCGACTTCGGTGCGCAGTACACCCAGCTGATTGCGCGGCGTATTCG
CGAGATCGGGGTCTACTGCGAGATTTGGGCGTGGGATCACGATCCGTCGGAGATTGCCGGTTTCGGTGCCAAGGGCATCA
TCCTGTCCGGCGGCCCGGAGTCGACCACGTCGCCGGGCGCACCGGTGGCGCCGCAGGAAGTGTTCGATAGCGGCCTGCCG
GTGTTCGGTATCTGCTACGGCATGCAGACCCTCGCCGCGCAATTGGGTGGTGCGACCGAGGCAGCGGATCAACGCGAATT
CGGCCATGCCGAAGTGGACGTGGTGGCGGCAGATGCCTTGTTCTCCGGCCTCACCGACCACGCCGGCGCCTCGCGCCTGA
ATGTATGGATGAGCCACGGCGACCACGTGTCGCAGGTGCCACCGGGCTTCACCATTACCGCCACGACCGACCGCATCCCG
GTGGCGGCCATGTCCAACGAAGCCAAGCGTTGGTACGGCGTGCAGTTCCATCCTGAGGTGACGCATACCTTGCAGGGCCA
GACCTTGCTGCGTCGCTTCGTGGTGGATGTCTGCGGCTGCCAGACGCTGTGGACCGCGGCCAACATCATCGAGGACCAGA
TCGCGCGCGTGCGCGAACAGGTGGGCGACGATGAAGTGATTCTTGGGTTGTCCGGCGGCGTCGATTCGTCGGTGGTGGCC
GCGCTGCTGCACAAGGCGATCGGCGACAAGCTGACCTGCGTGTTCGTCGATACCGGCTTGCTGCGTTGGCAGGAAGGCGA
CCAGGTGATGGCGATGTTCGCCGAGCACATGGGCGTCAAGGTGATTCGCGTCAACGCCGCCGACCGTTATTTCGCCAAGC
TTGAAGGCGTCAGCGACCCGGAAGCCAAGCGCAAGATCATCGGCAACCTGTTCGTGGAGATCTTCGACGAAGAATCCAAC
AAGCTGGCCAATGCCAAGTGGCTGGCGCAGGGTACGATCTATCCGGACGTGATCGAGTCGGCGGGCAGCAAGACCGGCAA
GGCGCACGTGATCAAGAGCCACCATAACGTCGGTGGCTTGCCCGAGCACATGAAGCTGGGCCTGGTCGAGCCGCTGCGCG
AATTGTTCAAGGACGAGGTGCGTCGCCTTGGCGTGGAACTCGGCCTGCCGCGCACCATGGTGTATCGCCACCCGTTCCCG
GGCCCCGGCCTGGGCGTACGCATCCTGGGCGAAGTGAAGCGCGAGTACGCCGAGTTGCTGGCCAAGGCCGACGCGATCTT
CATCGACGAACTGCGCAAGGCCGACCTGTACGACAAGACCAGCCAGGCCTTCGCCGTGTTCCTGCCGGTGAAGTCGGTCG
GCGTGGTCGGCGACGCCCGCGCCTACGAATGGGTGATCGCGCTGCGCGCGGTGGAGACCATCGACTTCATGACCGCGCAT
TGGGCGCACCTGCCGTACGACTTCCTCGGCACCGTGAGCAACCGCATCATCAACGAGCTGCGTGGTGTGTCGCGCGTGGT
CTACGACATCTCCGGCAAGCCGCCGGCGACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
TCGGGAATCGTAAGAGCCCGCCGCCTCCTCATCCGATAGCGGTCGGCGCTGCGTTTGCTGTTTCGATTCCCTCATCCCGA
TTCTCGATTCCCGGCTCTCA

Downstream 100 bases:

>100_bases
TTCTGCGTCTGGCACTGGCTGGCACCTAGTGACATCAAAACACACCTAAGCCCGTGTCAATGCGGGCTTTTTTTTGATTT
AGTTCGGCACTGCCTGGCAA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MTNIHTDKILILDFGAQYTQLIARRIREIGVYCEIWAWDHDPSEIAGFGAKGIILSGGPESTTSPGAPVAPQEVFDSGLP
VFGICYGMQTLAAQLGGATEAADQREFGHAEVDVVAADALFSGLTDHAGASRLNVWMSHGDHVSQVPPGFTITATTDRIP
VAAMSNEAKRWYGVQFHPEVTHTLQGQTLLRRFVVDVCGCQTLWTAANIIEDQIARVREQVGDDEVILGLSGGVDSSVVA
ALLHKAIGDKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVIRVNAADRYFAKLEGVSDPEAKRKIIGNLFVEIFDEESN
KLANAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFP
GPGLGVRILGEVKREYAELLAKADAIFIDELRKADLYDKTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAH
WAHLPYDFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE

Sequences:

>Translated_521_residues
MTNIHTDKILILDFGAQYTQLIARRIREIGVYCEIWAWDHDPSEIAGFGAKGIILSGGPESTTSPGAPVAPQEVFDSGLP
VFGICYGMQTLAAQLGGATEAADQREFGHAEVDVVAADALFSGLTDHAGASRLNVWMSHGDHVSQVPPGFTITATTDRIP
VAAMSNEAKRWYGVQFHPEVTHTLQGQTLLRRFVVDVCGCQTLWTAANIIEDQIARVREQVGDDEVILGLSGGVDSSVVA
ALLHKAIGDKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVIRVNAADRYFAKLEGVSDPEAKRKIIGNLFVEIFDEESN
KLANAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFP
GPGLGVRILGEVKREYAELLAKADAIFIDELRKADLYDKTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAH
WAHLPYDFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE
>Mature_520_residues
TNIHTDKILILDFGAQYTQLIARRIREIGVYCEIWAWDHDPSEIAGFGAKGIILSGGPESTTSPGAPVAPQEVFDSGLPV
FGICYGMQTLAAQLGGATEAADQREFGHAEVDVVAADALFSGLTDHAGASRLNVWMSHGDHVSQVPPGFTITATTDRIPV
AAMSNEAKRWYGVQFHPEVTHTLQGQTLLRRFVVDVCGCQTLWTAANIIEDQIARVREQVGDDEVILGLSGGVDSSVVAA
LLHKAIGDKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVIRVNAADRYFAKLEGVSDPEAKRKIIGNLFVEIFDEESNK
LANAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFPG
PGLGVRILGEVKREYAELLAKADAIFIDELRKADLYDKTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAHW
AHLPYDFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=559, Percent_Identity=35.778175313059, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=69.7318007662835, Blast_Score=779, Evalue=0.0,
Organism=Escherichia coli, GI1787517, Length=189, Percent_Identity=29.6296296296296, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=36.695652173913, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=36.695652173913, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=36.695652173913, Blast_Score=311, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=50.5747126436782, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=36.6726296958855, Blast_Score=301, Evalue=8e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57075; Mature: 56944

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIHTDKILILDFGAQYTQLIARRIREIGVYCEIWAWDHDPSEIAGFGAKGIILSGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEEECCCC
STTSPGAPVAPQEVFDSGLPVFGICYGMQTLAAQLGGATEAADQREFGHAEVDVVAADAL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEHHHH
FSGLTDHAGASRLNVWMSHGDHVSQVPPGFTITATTDRIPVAAMSNEAKRWYGVQFHPEV
HHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEHCCCCCHHHEECEEECCCH
THTLQGQTLLRRFVVDVCGCQTLWTAANIIEDQIARVREQVGDDEVILGLSGGVDSSVVA
HHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
ALLHKAIGDKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVIRVNAADRYFAKLEGVSDP
HHHHHHHCCCEEEEEEECCCEEECCCCHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCCH
EAKRKIIGNLFVEIFDEESNKLANAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGL
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCC
PEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFPGPGLGVRILGEVKREYAELL
CHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
AKADAIFIDELRKADLYDKTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAH
HHCCHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
WAHLPYDFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE
HHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC
>Mature Secondary Structure 
TNIHTDKILILDFGAQYTQLIARRIREIGVYCEIWAWDHDPSEIAGFGAKGIILSGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEEECCCC
STTSPGAPVAPQEVFDSGLPVFGICYGMQTLAAQLGGATEAADQREFGHAEVDVVAADAL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEHHHH
FSGLTDHAGASRLNVWMSHGDHVSQVPPGFTITATTDRIPVAAMSNEAKRWYGVQFHPEV
HHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEHCCCCCHHHEECEEECCCH
THTLQGQTLLRRFVVDVCGCQTLWTAANIIEDQIARVREQVGDDEVILGLSGGVDSSVVA
HHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
ALLHKAIGDKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVIRVNAADRYFAKLEGVSDP
HHHHHHHCCCEEEEEEECCCEEECCCCHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCCH
EAKRKIIGNLFVEIFDEESNKLANAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGL
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCC
PEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFPGPGLGVRILGEVKREYAELL
CHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
AKADAIFIDELRKADLYDKTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAH
HHCCHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
WAHLPYDFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE
HHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA