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The map label for this gene is fkpA [H]

Identifier: 78047975

GI number: 78047975

Start: 2744085

End: 2744528

Strand: Reverse

Name: fkpA [H]

Synonym: XCV2419

Alternate gene names: 78047975

Gene position: 2744528-2744085 (Counterclockwise)

Preceding gene: 78047979

Following gene: 78047974

Centisome position: 53.0

GC content: 65.77

Gene sequence:

>444_bases
ATGGACCCTGCCATGCGCCTTTTGTTGACGCTCGTTGTCGCCCTGTTGCTCGCAAGCTGCGCGCCCGCCCTGCCGCCCTC
CGGCGGCACCATCGCCAGTTTCGAGCGGATCGACCGCACCGTGGGGACCGGTGCAGAGGCCACACCAGGCGCCATGGTCA
CCGTGCACTACACCGGCTGGCTGTACGACGAAAAAGCCGCCGACAAGCACGGCAAGAAGTTCGACAGCTCGCTGGATCGC
GCCGAGCCGTTCCAATTCGTACTAGGTGGCCACCAGGTCATCCGCGGCTGGGACGATGGCGTGGCCGGCATGCGTGTCGG
CGGCAAGCGCACCTTGATGATTCCGCCCGATTACGGCTATGGCGACAACGGCGCCGGTGGCGTGATACCGCCCGGTGCAT
CGCTGGTGTTCGATTTGGAATTGCTGGGCGTGCAGCCGCGCTGA

Upstream 100 bases:

>100_bases
TCATCGGCTTCGTCGTCGGGAACATTGCGCAGATTGAGCAGCAGCTTGGCCATGCCGCGATGATACCGGGAGCCAGGTGC
GATAATGGCAGCCTTTCTCC

Downstream 100 bases:

>100_bases
GTGCCTGACGATGACTGATCTGAGCAGGCAGCGGCTGGCCGTGATCGGCGGTGGGCCGGCCGGTTTGATGGCGGCGGAAG
TGGCCTGCGCGGCAGGCTTG

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MDPAMRLLLTLVVALLLASCAPALPPSGGTIASFERIDRTVGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFDSSLDR
AEPFQFVLGGHQVIRGWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASLVFDLELLGVQPR

Sequences:

>Translated_147_residues
MDPAMRLLLTLVVALLLASCAPALPPSGGTIASFERIDRTVGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFDSSLDR
AEPFQFVLGGHQVIRGWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASLVFDLELLGVQPR
>Mature_147_residues
MDPAMRLLLTLVVALLLASCAPALPPSGGTIASFERIDRTVGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFDSSLDR
AEPFQFVLGGHQVIRGWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASLVFDLELLGVQPR

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=96, Percent_Identity=55.2083333333333, Blast_Score=106, Evalue=8e-24,
Organism=Homo sapiens, GI4503725, Length=96, Percent_Identity=55.2083333333333, Blast_Score=106, Evalue=8e-24,
Organism=Homo sapiens, GI206725530, Length=136, Percent_Identity=40.4411764705882, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI17149844, Length=136, Percent_Identity=40.4411764705882, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI17149842, Length=136, Percent_Identity=40.4411764705882, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI4758380, Length=96, Percent_Identity=46.875, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI4503729, Length=131, Percent_Identity=42.7480916030534, Blast_Score=93, Evalue=6e-20,
Organism=Homo sapiens, GI224809329, Length=109, Percent_Identity=48.6238532110092, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI224809327, Length=109, Percent_Identity=48.6238532110092, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4758384, Length=109, Percent_Identity=48.6238532110092, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI224809331, Length=112, Percent_Identity=47.3214285714286, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI8923659, Length=148, Percent_Identity=35.8108108108108, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI192448443, Length=121, Percent_Identity=40.495867768595, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI206725547, Length=149, Percent_Identity=32.2147651006711, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI33469985, Length=95, Percent_Identity=41.0526315789474, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI31317231, Length=150, Percent_Identity=32.6666666666667, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI150010552, Length=109, Percent_Identity=36.697247706422, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI87082390, Length=108, Percent_Identity=43.5185185185185, Blast_Score=77, Evalue=5e-16,
Organism=Escherichia coli, GI1789745, Length=105, Percent_Identity=44.7619047619048, Blast_Score=72, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=96, Percent_Identity=50, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=95, Percent_Identity=48.4210526315789, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=138, Percent_Identity=36.9565217391304, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17506169, Length=67, Percent_Identity=46.2686567164179, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17506167, Length=138, Percent_Identity=32.6086956521739, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561778, Length=100, Percent_Identity=40, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=100, Percent_Identity=53, Blast_Score=98, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=49.1071428571429, Blast_Score=95, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323566, Length=108, Percent_Identity=44.4444444444444, Blast_Score=84, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323482, Length=108, Percent_Identity=42.5925925925926, Blast_Score=80, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363946, Length=99, Percent_Identity=56.5656565656566, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17352457, Length=99, Percent_Identity=56.5656565656566, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24655568, Length=96, Percent_Identity=54.1666666666667, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24647110, Length=109, Percent_Identity=47.7064220183486, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=49.0384615384615, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356629, Length=144, Percent_Identity=43.0555555555556, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15480; Mature: 15480

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPAMRLLLTLVVALLLASCAPALPPSGGTIASFERIDRTVGTGAEATPGAMVTVHYTGW
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECE
LYDEKAADKHGKKFDSSLDRAEPFQFVLGGHQVIRGWDDGVAGMRVGGKRTLMIPPDYGY
EECCHHHHHCCCHHHHHCCCCCCHHEECCCCCEEECCCCCCCCEEECCCEEEEECCCCCC
GDNGAGGVIPPGASLVFDLELLGVQPR
CCCCCCCCCCCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MDPAMRLLLTLVVALLLASCAPALPPSGGTIASFERIDRTVGTGAEATPGAMVTVHYTGW
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECE
LYDEKAADKHGKKFDSSLDRAEPFQFVLGGHQVIRGWDDGVAGMRVGGKRTLMIPPDYGY
EECCHHHHHCCCHHHHHCCCCCCHHEECCCCCEEECCCCCCCCEEECCCEEEEECCCCCC
GDNGAGGVIPPGASLVFDLELLGVQPR
CCCCCCCCCCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]