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The map label for this gene is zwf1 [H]

Identifier: 78047793

GI number: 78047793

Start: 2569401

End: 2570960

Strand: Reverse

Name: zwf1 [H]

Synonym: XCV2237

Alternate gene names: 78047793

Gene position: 2570960-2569401 (Counterclockwise)

Preceding gene: 78047795

Following gene: 78047792

Centisome position: 49.65

GC content: 66.6

Gene sequence:

>1560_bases
GTGTCAGCGTCCATCCCCCGCTGCGCGCACGCAAGTGTCGCTCAGGAACAGACGTACCGACCGCCGGACGACCGGCGCCT
TTCCGACAAGCTGCTGATAACGATGTCTCCAGAATCTGAAACGCGGTCCATGCACAACACCCTGATCCTGTTTGGCGCCA
CCGGCGATCTTGCCCAGCGCTATCTCTTTCCTTCCCTGCTGCGCCTGTTCATCGACGGCCTGCTGCCGGAGGACTTCCGC
ATCCGTGCGCTGGCGCTGTCGCCGCACGACACCGATGCATTTCGCGAAGTACTGCGGCCACGCCTGACCGAAGCATTGCC
GATCGCGACCGCCGAACAGATCGACACGCTGCTGCAGCGAATCGATTACCGCTCGGTGGATCTGCGCGATGCCGAGTCGG
TGGCCAATGCGGTCCGCGAGCTGGCCAGCCGCCGCTGTGTGAGCTACCTGGCGATCCCGCCGGGCCTGTACATCAGCACC
TGCCAGGGCCTGGCGCTGGGTGGCGCGCTGGAGGCACCGCATCGCTTGATGCTGGAAAAACCGATCGGCCACGACTCCGA
CAGCGCCCGCGACATCCTGCAGTCGATCGGCGCGCTGATCGACGAGGACCGCGTGTTCCGCCTGGACCACTACCTGGGCA
AGGCGGCGGTGCAGAACCTGATCGCACTGCGCTTCGGCAACACGCTGCTGGAGGCGGTCTGGAACCGCGCCTACATCGAG
TCGGTGCAGATCCTGGTCGCCGAAAGCGAAGGCGTCGACGGGCGCGACGCCTACTACGCCCGCTCCGGCGCACTGCGCGA
CATGGTGCAGAGCCATATCCTGCAGCTGTTGTGCCTGGTGGCAATGGAGCCGCCGGCCTCGCTGGAAGCCGACCGCATCC
GCGATGAGAAGGTCAAGGTGCTGCGCGCCCTGCGTCCGATGACCGCCGAGCACGCCGCGCATGACTGCGTGCGCGGCCGC
TACACTGCCGGCAGCATCAACGGACAGCCGGCGCAGGCCTACCACCCGCCGGAAGGCAGTGACGTGGAGACCTTTGTCGC
CGTCACCGCGCATATCGACAACTGGCGTTGGGCCGGCGTGCCGTTCCACCTGTGCACCGGCAAGCGGCTGGCCGAGCGCT
CCACCCGCATCGTGGTGACGCTCAAGCCGGTGACGCATTGGCTGTTCGAACGCCCCGACCGCCAGAATGCGGTGCCGAAC
CGCCTGACCTTCCAGTTGCAGCCGCAGGAAAACATCGAACTCGGCCTGATGAGCAGCCTGGCTGGCCCGGAATGGGGCGC
GATCGAACTGCAGCCGCTGGAACTGGAACTGTCGGTGCCGACGGGCCTGCACCGTCGTATCGCCTACGAACGTCTGTTTG
TGGACGCCTTCAACGGCAACCCCGCGCTGTTCGTGCGCGACGACGAGGTCAAGGCAGCGTGGTCGTGGATCGACAGCGTC
AGCGACGCCTGGAAAGACGCCGCGCTGCCGCTGCAGCCCTACCCGGCCGGCAGCTGGGGGCCCGAATCTGCTGCCCACTT
CCTGCCCCCGGCCACCGACGCACAGGGAAACAACGCATGA

Upstream 100 bases:

>100_bases
CAGCTCGCCGCACGACGCATGGCATGCCATCACGCAGGTGCAGCTATGCCGCCATGGCGCTAACCGCTGATCGCCAGTTG
CTGCAACAATCCGGGACTGG

Downstream 100 bases:

>100_bases
CCGCTCCTTCCAAGCCGGTGCTGGTTGCCGATATCGGCGGAACCAATGCGCGCTTCGCGCTGGCCGATGTCGACGCTTCG
GTGCCGTTGCTGGATGACAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MSASIPRCAHASVAQEQTYRPPDDRRLSDKLLITMSPESETRSMHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFR
IRALALSPHDTDAFREVLRPRLTEALPIATAEQIDTLLQRIDYRSVDLRDAESVANAVRELASRRCVSYLAIPPGLYIST
CQGLALGGALEAPHRLMLEKPIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRAYIE
SVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAMEPPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGR
YTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPN
RLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSV
SDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA

Sequences:

>Translated_519_residues
MSASIPRCAHASVAQEQTYRPPDDRRLSDKLLITMSPESETRSMHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFR
IRALALSPHDTDAFREVLRPRLTEALPIATAEQIDTLLQRIDYRSVDLRDAESVANAVRELASRRCVSYLAIPPGLYIST
CQGLALGGALEAPHRLMLEKPIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRAYIE
SVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAMEPPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGR
YTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPN
RLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSV
SDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA
>Mature_518_residues
SASIPRCAHASVAQEQTYRPPDDRRLSDKLLITMSPESETRSMHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFRI
RALALSPHDTDAFREVLRPRLTEALPIATAEQIDTLLQRIDYRSVDLRDAESVANAVRELASRRCVSYLAIPPGLYISTC
QGLALGGALEAPHRLMLEKPIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRAYIES
VQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAMEPPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGRY
TAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNR
LTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSVS
DAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=478, Percent_Identity=33.8912133891213, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI108773793, Length=480, Percent_Identity=33.75, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI52145310, Length=495, Percent_Identity=28.6868686868687, Blast_Score=172, Evalue=8e-43,
Organism=Escherichia coli, GI1788158, Length=464, Percent_Identity=40.948275862069, Blast_Score=351, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI17538218, Length=483, Percent_Identity=33.9544513457557, Blast_Score=252, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6324088, Length=495, Percent_Identity=31.9191919191919, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24643350, Length=477, Percent_Identity=32.4947589098532, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24643352, Length=477, Percent_Identity=32.4947589098532, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI221513548, Length=496, Percent_Identity=28.2258064516129, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57671; Mature: 57540

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASIPRCAHASVAQEQTYRPPDDRRLSDKLLITMSPESETRSMHNTLILFGATGDLAQR
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCCEEEEEECCHHHHHH
YLFPSLLRLFIDGLLPEDFRIRALALSPHDTDAFREVLRPRLTEALPIATAEQIDTLLQR
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IDYRSVDLRDAESVANAVRELASRRCVSYLAIPPGLYISTCQGLALGGALEAPHRLMLEK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEECCCCCCCHHHHEEC
PIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRAYIE
CCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAMEPPASLEADRIRDEKVKV
HEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LRALRPMTAEHAAHDCVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGV
HHHHCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEECCC
PFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSL
CEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHC
AGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSV
CCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEEEEECCCHHHHHHHHHHH
SDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA
HHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SASIPRCAHASVAQEQTYRPPDDRRLSDKLLITMSPESETRSMHNTLILFGATGDLAQR
CCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCCEEEEEECCHHHHHH
YLFPSLLRLFIDGLLPEDFRIRALALSPHDTDAFREVLRPRLTEALPIATAEQIDTLLQR
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IDYRSVDLRDAESVANAVRELASRRCVSYLAIPPGLYISTCQGLALGGALEAPHRLMLEK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEECCCCCCCHHHHEEC
PIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRAYIE
CCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAMEPPASLEADRIRDEKVKV
HEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LRALRPMTAEHAAHDCVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGV
HHHHCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEECCC
PFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSL
CEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHC
AGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSV
CCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEEEEECCCHHHHHHHHHHH
SDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA
HHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]