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The map label for this gene is betA [H]

Identifier: 78047705

GI number: 78047705

Start: 2466961

End: 2468547

Strand: Reverse

Name: betA [H]

Synonym: XCV2149

Alternate gene names: 78047705

Gene position: 2468547-2466961 (Counterclockwise)

Preceding gene: 78047712

Following gene: 78047704

Centisome position: 47.67

GC content: 65.91

Gene sequence:

>1587_bases
ATGCCAATGATTTCCGATCCACTCCGATTGACAGCCGATACGCCGCAACTCACACGTCCTTACGACTTCATCGTCTGCGG
CGCAGGCCCCGCCGGCAGCGCCCTCGCCGCGCGGCTGGCAGAAAATCCGCAGGTCGAGGTCCTGCTGCTCGAAGCTGGCG
GCAGCGATGAGGTTCCGGAGGTGATGACCCCGACCCAATGGCCGCTCAATCTTGGCTCCGAGCGCGATTGGCAATTCGTT
GCCGAGCCCAATCCGCATCTGAACAATCGCGCGATTCCGCTCAACATGGGCAAGGTGGCGGGCGGTGGTTCGGCCATCAA
CGTGATGATGTGGGCACGCGGCCACCAGGCGGATTGGGACAGCTTTGCGCAGGAGGCCGGCGACGAGGGCTGGAGCTATC
GCTCGGTGCTGGATGTCTACCGCCGCATCGAAGACTGGCAAGGCATTGCCGATCCGCTGCGACGCGGTAGCGGCGGCCCG
GTCCATGTCGAAACCGCACGCGATCCGCATCCGGTTGCCAGCGCCATGGTCGAGGCCGCCGCATCCACCGGCCTGCCGAC
GTTCGATAGTCCCAATGGCGAGATGATGGAAGGCCGCGGCGGCGTCGCCTTGACCGAACTGATCGTCAAGGACGGCAGCC
GCGCGTCGATCTTTCGCGCTTACGTGTGGCCCAAGCGCCACCAGCCGAACCTGACCGTGCTGCTGCAGACGCAGGTGAGC
CGACTGCTGTTCGACGGCCACTCGGTGGTGGGCGTGGAAGCGATCGTTGGCGATCGTCGCCAACGGTTCATGGCCGACCG
CGAGGTGGTGGTGTCGCTGGGCGCGATCAATACACCCAAGCTGCTGATGCAGTCCGGGCTCGGCCCCGAATCGGAATTGC
GTCCCCATGGCATCCACGTCGTCCAGCATTTGCCGGGCGTCGGCCGCAACCACCAGGACCATGTGGCCTTCGGCTGCATC
TTCGAATCCAGGGCGCCGATCGCTGCGCAGTATGGCGGCTCGGAAGCCACGCTCTATTGGAAGACCGACCCGGCGTTGCA
GCTACCGGACGTGTTCCACTGCCAGCTGGAATTTCCGGTGGCTACGCCCGAAACCGCGCACATGGGCGCGCCGGACCACG
GCTGGATGGTGTTCGCCGGACTGTCGCATCCCAAGAGCCGCGGCAGCTTGCACCTGACCGGTAGCGATCCGGGCGCGCCG
CTGCGCATCCACGCCAACACGCTCTCCCACCCCGACGATCTACGGGCGGCGCGTGCCAGCGTTGCCATTGCCCGGGAGCT
TGCCCATGCACCGGCGTTCGATGCATTACTGAAGCGCGAAGCGATGCCCGGGCCGCTCTCGGGTGCGGAGATGGACCAAT
ACCTGCGCAACTCCGCCATCACCTTCTGGCACCAGGGGTGCACGGCGCGAATGGGCCGCGATGCCCTCTCCGTCGTCGAT
GGCCAACTGCGCGTGCACGGCATCGACCGCCTGCGCATCGCCGATGCCTCGATCCTGCCCAATGTCACCAGCGGCAACAC
GATGGCCCCGTGCGTGGTCATCGGTGAACGCGCCGCCGACATCATCAAAGCGGCCCATCGCCTCTGA

Upstream 100 bases:

>100_bases
GACAGGATCGCGCCGTGCTGGCTTGCGCCATGCATGCATCCCCCACCCTTTTCGGAAGCGCAAAGGCACTGCGTTGCCGC
TTCTCTACCGGATTCAAGAG

Downstream 100 bases:

>100_bases
GCCGTCTGACGCGTTTACCCACGCTCGTTCAACCAAGGAGATCCACCATGCGCTTTCCGTTCCCGTTACTGCTGACAGCC
ACCATGGCTGCCGCCACCAT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MPMISDPLRLTADTPQLTRPYDFIVCGAGPAGSALAARLAENPQVEVLLLEAGGSDEVPEVMTPTQWPLNLGSERDWQFV
AEPNPHLNNRAIPLNMGKVAGGGSAINVMMWARGHQADWDSFAQEAGDEGWSYRSVLDVYRRIEDWQGIADPLRRGSGGP
VHVETARDPHPVASAMVEAAASTGLPTFDSPNGEMMEGRGGVALTELIVKDGSRASIFRAYVWPKRHQPNLTVLLQTQVS
RLLFDGHSVVGVEAIVGDRRQRFMADREVVVSLGAINTPKLLMQSGLGPESELRPHGIHVVQHLPGVGRNHQDHVAFGCI
FESRAPIAAQYGGSEATLYWKTDPALQLPDVFHCQLEFPVATPETAHMGAPDHGWMVFAGLSHPKSRGSLHLTGSDPGAP
LRIHANTLSHPDDLRAARASVAIARELAHAPAFDALLKREAMPGPLSGAEMDQYLRNSAITFWHQGCTARMGRDALSVVD
GQLRVHGIDRLRIADASILPNVTSGNTMAPCVVIGERAADIIKAAHRL

Sequences:

>Translated_528_residues
MPMISDPLRLTADTPQLTRPYDFIVCGAGPAGSALAARLAENPQVEVLLLEAGGSDEVPEVMTPTQWPLNLGSERDWQFV
AEPNPHLNNRAIPLNMGKVAGGGSAINVMMWARGHQADWDSFAQEAGDEGWSYRSVLDVYRRIEDWQGIADPLRRGSGGP
VHVETARDPHPVASAMVEAAASTGLPTFDSPNGEMMEGRGGVALTELIVKDGSRASIFRAYVWPKRHQPNLTVLLQTQVS
RLLFDGHSVVGVEAIVGDRRQRFMADREVVVSLGAINTPKLLMQSGLGPESELRPHGIHVVQHLPGVGRNHQDHVAFGCI
FESRAPIAAQYGGSEATLYWKTDPALQLPDVFHCQLEFPVATPETAHMGAPDHGWMVFAGLSHPKSRGSLHLTGSDPGAP
LRIHANTLSHPDDLRAARASVAIARELAHAPAFDALLKREAMPGPLSGAEMDQYLRNSAITFWHQGCTARMGRDALSVVD
GQLRVHGIDRLRIADASILPNVTSGNTMAPCVVIGERAADIIKAAHRL
>Mature_527_residues
PMISDPLRLTADTPQLTRPYDFIVCGAGPAGSALAARLAENPQVEVLLLEAGGSDEVPEVMTPTQWPLNLGSERDWQFVA
EPNPHLNNRAIPLNMGKVAGGGSAINVMMWARGHQADWDSFAQEAGDEGWSYRSVLDVYRRIEDWQGIADPLRRGSGGPV
HVETARDPHPVASAMVEAAASTGLPTFDSPNGEMMEGRGGVALTELIVKDGSRASIFRAYVWPKRHQPNLTVLLQTQVSR
LLFDGHSVVGVEAIVGDRRQRFMADREVVVSLGAINTPKLLMQSGLGPESELRPHGIHVVQHLPGVGRNHQDHVAFGCIF
ESRAPIAAQYGGSEATLYWKTDPALQLPDVFHCQLEFPVATPETAHMGAPDHGWMVFAGLSHPKSRGSLHLTGSDPGAPL
RIHANTLSHPDDLRAARASVAIARELAHAPAFDALLKREAMPGPLSGAEMDQYLRNSAITFWHQGCTARMGRDALSVVDG
QLRVHGIDRLRIADASILPNVTSGNTMAPCVVIGERAADIIKAAHRL

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=540, Percent_Identity=34.2592592592593, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1786503, Length=543, Percent_Identity=35.7274401473296, Blast_Score=304, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17532301, Length=555, Percent_Identity=32.2522522522522, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24642048, Length=585, Percent_Identity=34.3589743589744, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24642039, Length=570, Percent_Identity=35.0877192982456, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=34.0909090909091, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24642055, Length=579, Percent_Identity=33.5060449050086, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24642042, Length=582, Percent_Identity=33.1615120274914, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI45551458, Length=595, Percent_Identity=30.5882352941176, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI45549471, Length=595, Percent_Identity=30.9243697478992, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=32.4275362318841, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24642035, Length=581, Percent_Identity=33.0464716006885, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24650267, Length=586, Percent_Identity=31.3993174061433, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24642037, Length=586, Percent_Identity=33.2764505119454, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=32.8070175438597, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24642051, Length=575, Percent_Identity=30.9565217391304, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI18859993, Length=568, Percent_Identity=30.1056338028169, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24645930, Length=576, Percent_Identity=27.2569444444444, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24642057, Length=581, Percent_Identity=26.8502581755594, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 57022; Mature: 56891

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMISDPLRLTADTPQLTRPYDFIVCGAGPAGSALAARLAENPQVEVLLLEAGGSDEVPE
CCCCCCCCEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCC
VMTPTQWPLNLGSERDWQFVAEPNPHLNNRAIPLNMGKVAGGGSAINVMMWARGHQADWD
CCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHH
SFAQEAGDEGWSYRSVLDVYRRIEDWQGIADPLRRGSGGPVHVETARDPHPVASAMVEAA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
ASTGLPTFDSPNGEMMEGRGGVALTELIVKDGSRASIFRAYVWPKRHQPNLTVLLQTQVS
HHCCCCCCCCCCCCEEECCCCCEEHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEHHHHH
RLLFDGHSVVGVEAIVGDRRQRFMADREVVVSLGAINTPKLLMQSGLGPESELRPHGIHV
HHHHCCCCEEEEHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHCCCCCHHCCCCCCHHH
VQHLPGVGRNHQDHVAFGCIFESRAPIAAQYGGSEATLYWKTDPALQLPDVFHCQLEFPV
HHHCCCCCCCCCCCEEEEEEECCCCCEEEECCCCEEEEEEECCCCCCCCCEEEEEEECCC
ATPETAHMGAPDHGWMVFAGLSHPKSRGSLHLTGSDPGAPLRIHANTLSHPDDLRAARAS
CCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHH
VAIARELAHAPAFDALLKREAMPGPLSGAEMDQYLRNSAITFWHQGCTARMGRDALSVVD
HHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHCCHHHHHHC
GQLRVHGIDRLRIADASILPNVTSGNTMAPCVVIGERAADIIKAAHRL
CEEEEECCCEEEEECHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHCC
>Mature Secondary Structure 
PMISDPLRLTADTPQLTRPYDFIVCGAGPAGSALAARLAENPQVEVLLLEAGGSDEVPE
CCCCCCCEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCC
VMTPTQWPLNLGSERDWQFVAEPNPHLNNRAIPLNMGKVAGGGSAINVMMWARGHQADWD
CCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHH
SFAQEAGDEGWSYRSVLDVYRRIEDWQGIADPLRRGSGGPVHVETARDPHPVASAMVEAA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
ASTGLPTFDSPNGEMMEGRGGVALTELIVKDGSRASIFRAYVWPKRHQPNLTVLLQTQVS
HHCCCCCCCCCCCCEEECCCCCEEHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEHHHHH
RLLFDGHSVVGVEAIVGDRRQRFMADREVVVSLGAINTPKLLMQSGLGPESELRPHGIHV
HHHHCCCCEEEEHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHCCCCCHHCCCCCCHHH
VQHLPGVGRNHQDHVAFGCIFESRAPIAAQYGGSEATLYWKTDPALQLPDVFHCQLEFPV
HHHCCCCCCCCCCCEEEEEEECCCCCEEEECCCCEEEEEEECCCCCCCCCEEEEEEECCC
ATPETAHMGAPDHGWMVFAGLSHPKSRGSLHLTGSDPGAPLRIHANTLSHPDDLRAARAS
CCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHH
VAIARELAHAPAFDALLKREAMPGPLSGAEMDQYLRNSAITFWHQGCTARMGRDALSVVD
HHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHCCHHHHHHC
GQLRVHGIDRLRIADASILPNVTSGNTMAPCVVIGERAADIIKAAHRL
CEEEEECCCEEEEECHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]