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The map label for this gene is moeB [H]

Identifier: 78047630

GI number: 78047630

Start: 2364993

End: 2366198

Strand: Reverse

Name: moeB [H]

Synonym: XCV2074

Alternate gene names: 78047630

Gene position: 2366198-2364993 (Counterclockwise)

Preceding gene: 78047636

Following gene: 78047621

Centisome position: 45.69

GC content: 65.75

Gene sequence:

>1206_bases
GTGCGTGCGTGTCATGGGCAAGACTGCACATCGCAGCTGCTGCGTTTGCGCGACAATGGCCGCATGAGTAGCCACGACAT
CTCTCCCGCCGACGCCCGTGCCCGCGCCCTGCAAGGCGCCCTGCTGGTCGACATCCGGCAACTGCATGAGCGTGCCAGCG
GCCAGGCCGAAGGCGCGTTGGCGATCGCACAGAACTCCCTGGAAACCGAGCCTGCAGCCCATCTGCCGGAGCAAACCCGC
GCAATCGTGTTGATCTGCCAGAGCGGCAAACGCTCGGCACACACGGCCGCCATCTTGCGCGCGCACGGCTATGCGCACGT
GGCGTCGGTGGCCGGTGGCACCAGCGCATGGGCCAGCGCCGGCCTGCCGTTGGTACGCCCGACGTTGCCGGCGGACGAGC
AGGATTTTCTTGAGCGTTATTCACGCCATCTGCGTCTGTCCCAGGTCGGCCTGGAAGGTCAGCGGCGCCTGGCGCGCGCG
CGGGTGTTGCTGATCGGCGCAGGCGGACTAGGCTCGCCGGCCGCGTTCTACCTCGCCGCAGCCGGTGTGGGGCATCTGCG
CATTGCCGACGACGACGTGGTGGACCGCAGCAACCTGCAACGCCAGATTCTGCACACCGAAGACAGCGTCGGCACTGCAA
AGGTCGACTCCGCCGCGCAGCGCATTGCCGCGCTCAACCCGCGCGTGGACATCGAGGCGGTGCGAACCCGCGTGACGGCC
GACAATGTCGAAGCGCTGCTGCAGGATGTGGATGTGGTGGTGGATGGCGCAGATAATTTTCCTGCGCGGTATTTGCTCAA
CGATGCGTGCGTCAAATTCGGTAAACCACTGGTTTACGGCGCCGTGCAGCAGTTCGAAGGACAGGTCAGCGTGTTCGATG
CCGGCCGCCACCGCGGTCATGCGCCCTGCTACCGCTGCCTGTTTCCCGAACCACCGCCGCCGGAATTCGCGCCCAGTTGT
GCCGAGGCTGGTGTGCTCGGCGTACTGCCCGGAGTGATCGGACTCTTGCAAGCCACCGAAGCGATCAAGTTGCTGCTCGG
CATTGGTGACGGCCTCACTGGCCGCCTGCTCAGTTTCGATGCATTGGCGATGCGCTTTCGCGACATCCGCTTGTCGCCGG
ACCCGCACTGCCCGGTGTGCGCGCCTGGCGCGGCATTTCGCGGTTATGCAGATTACGCGGCGTTCTGCGGTAGTGCGGTT
GGTTGA

Upstream 100 bases:

>100_bases
GTGTTGAACAAGGCCGAATTACAGCGGTGCCGCTCGCAGTGCAGCGTGATCGCGTCCGCCATCGCACCGCAATCATGACG
CGCCTTTCATCAACGGCGAG

Downstream 100 bases:

>100_bases
GCGAGCCCACAGCGGCGTGCGGTGTCGGTCGCTGACTGATTGGCTTGCCGCCGATGCAATGCGAGGTATATCGGTACGTC
AAACATTTCGGCGACGTTTG

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MRACHGQDCTSQLLRLRDNGRMSSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAAHLPEQTR
AIVLICQSGKRSAHTAAILRAHGYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARA
RVLLIGAGGLGSPAAFYLAAAGVGHLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAAQRIAALNPRVDIEAVRTRVTA
DNVEALLQDVDVVVDGADNFPARYLLNDACVKFGKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSC
AEAGVLGVLPGVIGLLQATEAIKLLLGIGDGLTGRLLSFDALAMRFRDIRLSPDPHCPVCAPGAAFRGYADYAAFCGSAV
G

Sequences:

>Translated_401_residues
MRACHGQDCTSQLLRLRDNGRMSSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAAHLPEQTR
AIVLICQSGKRSAHTAAILRAHGYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARA
RVLLIGAGGLGSPAAFYLAAAGVGHLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAAQRIAALNPRVDIEAVRTRVTA
DNVEALLQDVDVVVDGADNFPARYLLNDACVKFGKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSC
AEAGVLGVLPGVIGLLQATEAIKLLLGIGDGLTGRLLSFDALAMRFRDIRLSPDPHCPVCAPGAAFRGYADYAAFCGSAV
G
>Mature_401_residues
MRACHGQDCTSQLLRLRDNGRMSSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAAHLPEQTR
AIVLICQSGKRSAHTAAILRAHGYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARA
RVLLIGAGGLGSPAAFYLAAAGVGHLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAAQRIAALNPRVDIEAVRTRVTA
DNVEALLQDVDVVVDGADNFPARYLLNDACVKFGKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSC
AEAGVLGVLPGVIGLLQATEAIKLLLGIGDGLTGRLLSFDALAMRFRDIRLSPDPHCPVCAPGAAFRGYADYAAFCGSAV
G

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=274, Percent_Identity=46.3503649635037, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4885649, Length=173, Percent_Identity=32.3699421965318, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI23510338, Length=178, Percent_Identity=28.6516853932584, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI23510340, Length=178, Percent_Identity=28.6516853932584, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787048, Length=248, Percent_Identity=42.741935483871, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082356, Length=249, Percent_Identity=43.3734939759036, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1789177, Length=144, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=261, Percent_Identity=41.3793103448276, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI193203301, Length=172, Percent_Identity=29.6511627906977, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71984476, Length=187, Percent_Identity=28.3422459893048, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=272, Percent_Identity=34.9264705882353, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6322639, Length=164, Percent_Identity=28.6585365853659, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=144, Percent_Identity=29.8611111111111, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582879, Length=265, Percent_Identity=46.4150943396226, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24660640, Length=154, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641311, Length=265, Percent_Identity=29.4339622641509, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20129973, Length=181, Percent_Identity=28.7292817679558, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357111, Length=147, Percent_Identity=34.0136054421769, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573937, Length=156, Percent_Identity=29.4871794871795, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 42543; Mature: 42543

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRACHGQDCTSQLLRLRDNGRMSSHDISPADARARALQGALLVDIRQLHERASGQAEGAL
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AIAQNSLETEPAAHLPEQTRAIVLICQSGKRSAHTAAILRAHGYAHVASVAGGTSAWASA
EEECCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHC
GLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARARVLLIGAGGLGSPAAFYLAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEEECCCCCCHHHHHHHH
AGVGHLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAAQRIAALNPRVDIEAVRTRVTA
CCCCEEEECCCCHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DNVEALLQDVDVVVDGADNFPARYLLNDACVKFGKPLVYGAVQQFEGQVSVFDAGRHRGH
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCC
APCYRCLFPEPPPPEFAPSCAEAGVLGVLPGVIGLLQATEAIKLLLGIGDGLTGRLLSFD
CCEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALAMRFRDIRLSPDPHCPVCAPGAAFRGYADYAAFCGSAVG
HHHHHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCC
>Mature Secondary Structure
MRACHGQDCTSQLLRLRDNGRMSSHDISPADARARALQGALLVDIRQLHERASGQAEGAL
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AIAQNSLETEPAAHLPEQTRAIVLICQSGKRSAHTAAILRAHGYAHVASVAGGTSAWASA
EEECCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHC
GLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARARVLLIGAGGLGSPAAFYLAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEEECCCCCCHHHHHHHH
AGVGHLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAAQRIAALNPRVDIEAVRTRVTA
CCCCEEEECCCCHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DNVEALLQDVDVVVDGADNFPARYLLNDACVKFGKPLVYGAVQQFEGQVSVFDAGRHRGH
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCC
APCYRCLFPEPPPPEFAPSCAEAGVLGVLPGVIGLLQATEAIKLLLGIGDGLTGRLLSFD
CCEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALAMRFRDIRLSPDPHCPVCAPGAAFRGYADYAAFCGSAVG
HHHHHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA