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The map label for this gene is uvrY [H]

Identifier: 78047573

GI number: 78047573

Start: 2298980

End: 2299645

Strand: Reverse

Name: uvrY [H]

Synonym: XCV2017

Alternate gene names: 78047573

Gene position: 2299645-2298980 (Counterclockwise)

Preceding gene: 78047574

Following gene: 78047572

Centisome position: 44.41

GC content: 65.47

Gene sequence:

>666_bases
GTGCCCTTTACTGAAAAAGGTCTCTTCTGCGCCGTGCGAGTCATCATCGTCGACGATCACACCCTTGTCCGTGCCGGCCT
GTCCAGGCTGCTGCAAACCTTCGCCGGCATCGATGTCGTGGGCGAAGCCAGCAATGCGCAACAAGCCCTGGACATGACGT
CCCTGCACCGGCCCGACCTGGTGCTGATGGACCTGTCTTTGCCCGGCCGCAGCGGCCTGGATGCCATGACCGACGTGCTG
CGCGCCGCGCCGCGCACGCACGTGGTGATGATGTCGATGCACGACGACCCGGTGCATGTGCGCGATGCGCTCGATCGCGG
CGCGGTCGGCTTCGTGGTCAAGGACGCCGCGCCGCTGGAGCTGGAATTGGCGTTGCGCGCTGCCGCCGCCGGCCAGGTGT
TCCTGAGCCCGCAGATCTCGTCCAAGATGATTGCGCCGATGCTGGGCCGCGAAAAGCCGGTCGGCATTGCCGCGCTGTCG
CCGCGTCAGCGCGAGATCCTGCGCGAAATCGGCCGCGGCCAGAGCAACAAGGAAATCGCCGCCGATTTGGGCATCAGCGT
CAAGACCGTGGAAACCCACCGCGCCCGCATGATGGAATCGCTCGGATGCCGTCGCGCCAACGATCTGGTGCTGCTGGCCG
CCAAACATCACAACGAGTTGGTCTGA

Upstream 100 bases:

>100_bases
CGCTGGAACGCCACCTGTTTCGCTTGCACCGCCGTCAGATCGCCGACGCCCGCCGCCAGCGTTGATCCGATAGTTGGCGC
CGGGCGCCGGGTCAGCTAAG

Downstream 100 bases:

>100_bases
CGCGCCATCCGGGCAAGCGTGGGCCAGCGACGCTGAAAACAGTGACGGGATTCCGGCGGGCACGCTTGAGCCCGCCTGCA
ACGTCAGGAAGTTCCTGACA

Product: LuxR family two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MPFTEKGLFCAVRVIIVDDHTLVRAGLSRLLQTFAGIDVVGEASNAQQALDMTSLHRPDLVLMDLSLPGRSGLDAMTDVL
RAAPRTHVVMMSMHDDPVHVRDALDRGAVGFVVKDAAPLELELALRAAAAGQVFLSPQISSKMIAPMLGREKPVGIAALS
PRQREILREIGRGQSNKEIAADLGISVKTVETHRARMMESLGCRRANDLVLLAAKHHNELV

Sequences:

>Translated_221_residues
MPFTEKGLFCAVRVIIVDDHTLVRAGLSRLLQTFAGIDVVGEASNAQQALDMTSLHRPDLVLMDLSLPGRSGLDAMTDVL
RAAPRTHVVMMSMHDDPVHVRDALDRGAVGFVVKDAAPLELELALRAAAAGQVFLSPQISSKMIAPMLGREKPVGIAALS
PRQREILREIGRGQSNKEIAADLGISVKTVETHRARMMESLGCRRANDLVLLAAKHHNELV
>Mature_220_residues
PFTEKGLFCAVRVIIVDDHTLVRAGLSRLLQTFAGIDVVGEASNAQQALDMTSLHRPDLVLMDLSLPGRSGLDAMTDVLR
AAPRTHVVMMSMHDDPVHVRDALDRGAVGFVVKDAAPLELELALRAAAAGQVFLSPQISSKMIAPMLGREKPVGIAALSP
RQREILREIGRGQSNKEIAADLGISVKTVETHRARMMESLGCRRANDLVLLAAKHHNELV

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=207, Percent_Identity=36.231884057971, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=35.5, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=34.020618556701, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=36.4130434782609, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788712, Length=202, Percent_Identity=27.2277227722772, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=29.9019607843137, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1786747, Length=197, Percent_Identity=27.9187817258883, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082052, Length=124, Percent_Identity=33.8709677419355, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23934; Mature: 23803

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFTEKGLFCAVRVIIVDDHTLVRAGLSRLLQTFAGIDVVGEASNAQQALDMTSLHRPDL
CCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCE
VLMDLSLPGRSGLDAMTDVLRAAPRTHVVMMSMHDDPVHVRDALDRGAVGFVVKDAAPLE
EEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCC
LELALRAAAAGQVFLSPQISSKMIAPMLGREKPVGIAALSPRQREILREIGRGQSNKEIA
HHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCCCHHH
ADLGISVKTVETHRARMMESLGCRRANDLVLLAAKHHNELV
HHCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
PFTEKGLFCAVRVIIVDDHTLVRAGLSRLLQTFAGIDVVGEASNAQQALDMTSLHRPDL
CCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCE
VLMDLSLPGRSGLDAMTDVLRAAPRTHVVMMSMHDDPVHVRDALDRGAVGFVVKDAAPLE
EEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCC
LELALRAAAAGQVFLSPQISSKMIAPMLGREKPVGIAALSPRQREILREIGRGQSNKEIA
HHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCCCHHH
ADLGISVKTVETHRARMMESLGCRRANDLVLLAAKHHNELV
HHCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]