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The map label for this gene is proP [H]

Identifier: 78047387

GI number: 78047387

Start: 2068463

End: 2069746

Strand: Reverse

Name: proP [H]

Synonym: XCV1831

Alternate gene names: 78047387

Gene position: 2069746-2068463 (Counterclockwise)

Preceding gene: 78047388

Following gene: 78047384

Centisome position: 39.97

GC content: 65.58

Gene sequence:

>1284_bases
ATGACCACCCATGCCCCACCGACGCAGCTCACCCGCAGCGATTACAAAACCCTGGGCTTGTCCGCGCTGGGCGGCGCGCT
GGAGTTCTACGATTTCATCATCTTCATTTTTTTCGCGAAGGTGCTGGGCGAGCTGTTCTTTCCGCCCGGTATTCCGGAGT
GGACGCGGCAACTGCAGACATTCGGCATCTTTGCGGCCGGCTACCTGATCCGGCCGTTGGGCGGCATTGTGATGGCGCAT
TTTGGCGATCTGCTTGGTCGCAAGCGCATGTTCGCGCTGAGCATCGGATTGATGGCGCTGCCCACACTGGCCATCGGCGT
GCTGCCGACCTACGCGCAGATCGGCCTGGCCGCGCCGCTGCTGCTGTTGACGATGCGCCTGCTGCAGGGCGCAGCCATCG
GTGGCGAAGTGCCCAGTGCGTGGGTGTTCGTGGCAGAGCACGTCCCCGCGCGGCGCACAGGGCTGGCCTGCGGCACCTTG
ACCGCTGGCCTGGCTGCCGGCGTGCTGCTTGGTTCGCTGAGTGCCGGCGCACTGAATCGTGCGTTTTCTCCGGAGGAAAT
CGCCGAGTACGCCTGGCGCCTGCCGTTTTTGGCCGGCGGCATCTTCGGCCTGCTGTCGGTGTACCTGCGGCGATGGCTGC
ATGAAACGCCGGTGTTCGCCGAACTGGTCGCCATGCGCGCGTTGGCGCGCGAGACGCCACTGAAGGTGGTGCTGCGCGAT
CACCCGCGCAGTCTGGCAATGTCGCTCTGGCTGACCTGGGTGATCGCCGCTGCAGTGCTGGTGGTGTCGCTGATGACACC
CACGCTGCTGCAGAGTGCGTACGGCTATCCGGCACCGGTGGCATTGCAGGCCAATCTTCTGGCAGTGCTGCTGCAGGCGA
TCGGCTCGGTGGTGGCCGGGGCACTCTCGGACCGTTGGGGCAACGGGCGTGTGCTGCTGGCCGGCAGCGTGCTTCTGGGT
ATCAGCGCATGGCTGTTCTACCGCTTTGCGGGCGACCCGCGCCTGCTGTTTCCGCTCTATGCCCTGCTCGGCACTGCGCT
GGGCGTGCTGGGTGCAATTCCGCGCGTGATGGTCGAGGCGTTTCCACCGGTGGTTCGGCTGTCCGGCGTGTCGTTCGCCT
ACAACCTGGGCTATGCCGTATTCGGCGGCCTGACTCCGCTGCTGGTGGTGATGCTGCTCAAGCAGCACCCGATGGGGCCG
GCGTACTACGTCATCTTGCTGGCTTCCATCGGCGCCATGGTTGGCGCCCGGTTATCGCAACGGGAGCGGATCGGCCGCGG
TTAA

Upstream 100 bases:

>100_bases
ACGGCGTAGCGACGGCCCCGCCCGGCAGCTAGCATTGCCTGCTCGGCGCATCAGCAGGCTTCAATGGCAATGCGCGCCAC
CCGCGACAGGATGCGACTGC

Downstream 100 bases:

>100_bases
TCGGCAAACGGCACACGCCCGGGCTGCTCCGCCACCGCTCCAGCCGGCGTGCGCCAATGCGGCCGCCGCGCGCCGCGGAA
CATCACCAGATACAGCCCGA

Product: metabolite:H+ symporter family protein

Products: betaine [Cytoplasm]; Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTTHAPPTQLTRSDYKTLGLSALGGALEFYDFIIFIFFAKVLGELFFPPGIPEWTRQLQTFGIFAAGYLIRPLGGIVMAH
FGDLLGRKRMFALSIGLMALPTLAIGVLPTYAQIGLAAPLLLLTMRLLQGAAIGGEVPSAWVFVAEHVPARRTGLACGTL
TAGLAAGVLLGSLSAGALNRAFSPEEIAEYAWRLPFLAGGIFGLLSVYLRRWLHETPVFAELVAMRALARETPLKVVLRD
HPRSLAMSLWLTWVIAAAVLVVSLMTPTLLQSAYGYPAPVALQANLLAVLLQAIGSVVAGALSDRWGNGRVLLAGSVLLG
ISAWLFYRFAGDPRLLFPLYALLGTALGVLGAIPRVMVEAFPPVVRLSGVSFAYNLGYAVFGGLTPLLVVMLLKQHPMGP
AYYVILLASIGAMVGARLSQRERIGRG

Sequences:

>Translated_427_residues
MTTHAPPTQLTRSDYKTLGLSALGGALEFYDFIIFIFFAKVLGELFFPPGIPEWTRQLQTFGIFAAGYLIRPLGGIVMAH
FGDLLGRKRMFALSIGLMALPTLAIGVLPTYAQIGLAAPLLLLTMRLLQGAAIGGEVPSAWVFVAEHVPARRTGLACGTL
TAGLAAGVLLGSLSAGALNRAFSPEEIAEYAWRLPFLAGGIFGLLSVYLRRWLHETPVFAELVAMRALARETPLKVVLRD
HPRSLAMSLWLTWVIAAAVLVVSLMTPTLLQSAYGYPAPVALQANLLAVLLQAIGSVVAGALSDRWGNGRVLLAGSVLLG
ISAWLFYRFAGDPRLLFPLYALLGTALGVLGAIPRVMVEAFPPVVRLSGVSFAYNLGYAVFGGLTPLLVVMLLKQHPMGP
AYYVILLASIGAMVGARLSQRERIGRG
>Mature_426_residues
TTHAPPTQLTRSDYKTLGLSALGGALEFYDFIIFIFFAKVLGELFFPPGIPEWTRQLQTFGIFAAGYLIRPLGGIVMAHF
GDLLGRKRMFALSIGLMALPTLAIGVLPTYAQIGLAAPLLLLTMRLLQGAAIGGEVPSAWVFVAEHVPARRTGLACGTLT
AGLAAGVLLGSLSAGALNRAFSPEEIAEYAWRLPFLAGGIFGLLSVYLRRWLHETPVFAELVAMRALARETPLKVVLRDH
PRSLAMSLWLTWVIAAAVLVVSLMTPTLLQSAYGYPAPVALQANLLAVLLQAIGSVVAGALSDRWGNGRVLLAGSVLLGI
SAWLFYRFAGDPRLLFPLYALLGTALGVLGAIPRVMVEAFPPVVRLSGVSFAYNLGYAVFGGLTPLLVVMLLKQHPMGPA
YYVILLASIGAMVGARLSQRERIGRG

Specific function: May be a proton symporter invoved in the uptake of osmolytes such as proline and glycine betaine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790550, Length=434, Percent_Identity=32.0276497695853, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1788292, Length=431, Percent_Identity=28.0742459396752, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789941, Length=397, Percent_Identity=29.7229219143577, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788942, Length=437, Percent_Identity=29.9771167048055, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082231, Length=465, Percent_Identity=24.0860215053763, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87082404, Length=405, Percent_Identity=22.4691358024691, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45635; Mature: 45504

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCC
>Mature Secondary Structure 
TTHAPPTQLTRSDYKTLGLSALGGALEFYDFIIFIFFAKVLGELFFPPGIPEWTRQLQT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH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HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: betaine [Periplasm]; Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + betaine [Periplasm] = Proton [Cytoplasm] + betaine [Cytoplasm] Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]