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The map label for this gene is lpxD [H]

Identifier: 78047024

GI number: 78047024

Start: 1649708

End: 1650721

Strand: Reverse

Name: lpxD [H]

Synonym: XCV1468

Alternate gene names: 78047024

Gene position: 1650721-1649708 (Counterclockwise)

Preceding gene: 78047026

Following gene: 78047023

Centisome position: 31.88

GC content: 66.37

Gene sequence:

>1014_bases
ATGCGATTGACCGCCAGTGCGATTGCCGAACAATTCGGGTTGACCGTCGTCGGTGACGGCACCACCGAAGTCAGCGGCGT
CGCCACCCTGGCCCATGCCGGCGCAGGCCAGCTGAGCTTCCTGTCCAACCCGCGCTATCGTCCGCAACTGGCCGACACCC
AGGCCGCCGTCGTAGTGCTACGCGCCGACGATGCCGACGCCGCCAAGGGCACCGCGCTGGTCGCCAAGGATCCGTATACC
GCATTCGCCAAGATCGCCGCGCTGTTCGACGTGGCACCGGTGCGCGAACCGGGCATCCATGCCTCTGCGGTGATCGACCC
GACCGCGCAGGTGTCGCCTGGCGCGCATGTCGGTCCGTTCGTCAGCATCGGTGCGCGTAGTCGCGTGGGCGATGGCTGCG
TGATCGGCACCGGCAGCATCATCGGCGAGGACTGCGTGGTGGACGAGGGGAGCGAACTGCTCGCCCGCGTCACCCTGGTC
ACGCGCGTGCGGTTGGGCAAGCGCGTGCGCATCCACCCTGGCGCGGTGATCGGCGCCGACGGCTTCGGCCTGGCCATGGA
TGCCGGGCACTGGATCAAGGTGCCCCAGCTCGGCGGTGTGGTGATCGGCGACGACTGCGAAATCGGTGCCAATACCTGCA
TCGACCGCGGTGCGCTGGAAGACACCGTGCTGGAAGAAGACGTGCGCGTGGACAACCTGGTGCAGATCGCGCACAACTGC
CGCATCGGCGCGCACAGTGCGATCGCCGGCTGCACCGGCATTGCCGGTAGCGCCAAGATCGGCCGTTATTGCCTGCTTGG
CGGGCATGTCGGCGTGGTCGGCCACCTGGAGATCTGCGACAAGGTGGTGATCACCGGCAAGTCTGTCGTGCGTAATTCCA
TCCATGAGCCGGGCGAGTATTCGTCCGGCACCCCTCTCACCGACAATCGCACGTGGCGCAAAAACGCCGCGCGCTTCAAG
CAGCTTGATGTGCTCGCTAGGCGCATCCTGGCTGTGGGCAAGGAGAAAGAATGA

Upstream 100 bases:

>100_bases
TTGCGGCCCGGCAAGCAATACGCTCGACTGTTTAGCCAACTTTTGGCGACGTTTTCCCCCTGTTAAACCAGCACCTACCG
TTTACGCGAGGTTTACCCTG

Downstream 100 bases:

>100_bases
GCCACCACGTTTACGAACTGCCGATCGACGTCAGTCAAATCCAGACGCTGCTCCCGCACCGTTACCCGTTTCTGCTGGTC
GACCGCATCCTCGAACTCGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVLRADDADAAKGTALVAKDPYT
AFAKIAALFDVAPVREPGIHASAVIDPTAQVSPGAHVGPFVSIGARSRVGDGCVIGTGSIIGEDCVVDEGSELLARVTLV
TRVRLGKRVRIHPGAVIGADGFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEYSSGTPLTDNRTWRKNAARFK
QLDVLARRILAVGKEKE

Sequences:

>Translated_337_residues
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVLRADDADAAKGTALVAKDPYT
AFAKIAALFDVAPVREPGIHASAVIDPTAQVSPGAHVGPFVSIGARSRVGDGCVIGTGSIIGEDCVVDEGSELLARVTLV
TRVRLGKRVRIHPGAVIGADGFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEYSSGTPLTDNRTWRKNAARFK
QLDVLARRILAVGKEKE
>Mature_337_residues
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVLRADDADAAKGTALVAKDPYT
AFAKIAALFDVAPVREPGIHASAVIDPTAQVSPGAHVGPFVSIGARSRVGDGCVIGTGSIIGEDCVVDEGSELLARVTLV
TRVRLGKRVRIHPGAVIGADGFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEYSSGTPLTDNRTWRKNAARFK
QLDVLARRILAVGKEKE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=328, Percent_Identity=43.9024390243902, Blast_Score=288, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 34972; Mature: 34972

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVL
CCCCHHHHHHHHCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEE
RADDADAAKGTALVAKDPYTAFAKIAALFDVAPVREPGIHASAVIDPTAQVSPGAHVGPF
ECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCE
VSIGARSRVGDGCVIGTGSIIGEDCVVDEGSELLARVTLVTRVRLGKRVRIHPGAVIGAD
EEECCCCCCCCCEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEECCCEEECCC
GFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
CCEEEECCCCEEECCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEY
CCCCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEHHHHHCEEEECCHHHHHHHCCCCCCC
SSGTPLTDNRTWRKNAARFKQLDVLARRILAVGKEKE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVL
CCCCHHHHHHHHCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEE
RADDADAAKGTALVAKDPYTAFAKIAALFDVAPVREPGIHASAVIDPTAQVSPGAHVGPF
ECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCE
VSIGARSRVGDGCVIGTGSIIGEDCVVDEGSELLARVTLVTRVRLGKRVRIHPGAVIGAD
EEECCCCCCCCCEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEECCCEEECCC
GFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
CCEEEECCCCEEECCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEY
CCCCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEHHHHHCEEEECCHHHHHHHCCCCCCC
SSGTPLTDNRTWRKNAARFKQLDVLARRILAVGKEKE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]