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The map label for this gene is lig [H]

Identifier: 78046950

GI number: 78046950

Start: 1573982

End: 1575586

Strand: Reverse

Name: lig [H]

Synonym: XCV1394

Alternate gene names: 78046950

Gene position: 1575586-1573982 (Counterclockwise)

Preceding gene: 78046951

Following gene: 78046949

Centisome position: 30.43

GC content: 66.79

Gene sequence:

>1605_bases
GTGAAGCGTTTCGCGGCGTTGTACCGCGCCCTGGACCGCAGCACCGGCACGCTCGACAAGCGCGCTGCGCTGGTTGCGTA
TTTCCGCGATGCGCCCGCGCTGGACGCGGCATGGGCGCTGTATCTGCTGGCCGGTGGCAAGGTGGCCAGCGCGCGCATGC
GCATTGCCAGCAGCGGCGAACTGCGTGAATGGATCACCGACACCGCCGGCGTTGCCGATTGGCTGGTCGCCGACAGCTAC
GACCATGTCGGCGATCTGGCCGAAACCCTGGCCTTGCTGCTGGACGACCCGGTCGCCGAGGCGGCCGATCTGCCATTGGC
AGAATGGATCGAACAGCGGCTGCTGCCGATCGCCAACCAGGACGTGCAAGTCCGCAAGGCCTGCATCGTGCAGGCGTGGC
GCAGCCTGGCCTTCGACGAGCGGCTGGTGTTCAACAAGCTGCTGACCGGCGCATTGCGGGTTGGGGTGTCGCAACGGCTC
GTGCAGCAGGCGCTGGCCGAATTGTCGGGGGTGGATATCGCGCGCATTGCGCAGCGCATGCTCGGCAGTTGGCGGCCGCA
TCCCACCTATCTTGCAGACCTGTTGACCAGCGAAGAACTGCCCGGCGACCGCCAGCAGCCCTATCCGTTCTTTCTGGCAT
CGCCGCTGGAAGCGGAGGTCGACACGCTGGGCGCCATCGACGACTGGCTGCTGGAATGGAAATGGGACGGCATCCGCCTG
CAGCTGATTCGCCGCGCCGGCGAAGCGGCGCTGTGGTCGCGCGGCGAAGAGCGTCTGGATGGACGTTTCCCCGAAATCGA
ACACGCCGCACTGCAATTGCCGGACGGCACCGTCATCGATGGCGAGCTGCTGGCCTGGCAACCCGAACAGCCCCTGCCAA
TGCCGTTTACCGCGTTGCAGACGCGCATCCAACGGCTCAAGCCCGGGCCCAAGACATTGGCCGCCGCACCTGCGCGCGTG
GTGGCCTACGACCTGCTGGAACTGGCGGGCGAAGACCTGCGCGAGCGCCCGTTGCAGGAGCGGCGCGCACTGCTGGAAGG
CGTGCTCGCCACGCTGGCAGATCCGCGCATCGTTGCCTCGCCGCTGGTGCAGGTCAGCGATTGGCAGGCCGCAGCGCAGG
TGCGCGTGGAAGCGCGCGAACGCGGCGTGGAAGGGCTGATGCTCAAGCGCGCCAGTTCGGTGTATCAATCCGGTCGCCGT
CGCGGCGATTGGTGGAAATGGAAGATCGACCCACTGACCATCGACGCGGTGCTGCTGTACGCGCAGGCCGGCCACGGCAG
ACGCAGCACGCTCTACACCGACTACACCTTCGGGCTATGGCACGAGGGCCAACTGGTGCCGATCGCCAAGGCCTATTCGG
GCCTGGACGACAAGGAAATTCTTCAACTGGATCGCTGGATCCGTGCCAACACCACCGAGCGCTTCGGCCCGGTGCGCGCG
GTCACCGCCCATCATGTGTTCGAGCTGGGATTTGAAGCGGTGAACCGCAGCGCGCGGCACAAGTCCGGCATCGCGGTGCG
CTTCCCGCGCATCCTGCGCTGGCGTCACGACAAGCCGATGGCCGAAGCCGATCATCTGAGCACCCTGCAGGCACTGGCGC
GGTGA

Upstream 100 bases:

>100_bases
CACCGCGACCGCTGCGGCGCCCACGCGTGCTTGCCGCGTTTACCCGACGCGCACTGGAGCTGCGTGCTGCCGACAGGCGC
GCAGCGACACAGGCGCTGCC

Downstream 100 bases:

>100_bases
GCGTCACGCAGCACACGTATGGCACGCCACTGCAACAGTGGCGTGCCTGGTTCGCGCAGCGCGGCTGGGCGCCACTGCCG
TTTCAACGCGATGTGTGGAA

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKRFAALYRALDRSTGTLDKRAALVAYFRDAPALDAAWALYLLAGGKVASARMRIASSGELREWITDTAGVADWLVADSY
DHVGDLAETLALLLDDPVAEAADLPLAEWIEQRLLPIANQDVQVRKACIVQAWRSLAFDERLVFNKLLTGALRVGVSQRL
VQQALAELSGVDIARIAQRMLGSWRPHPTYLADLLTSEELPGDRQQPYPFFLASPLEAEVDTLGAIDDWLLEWKWDGIRL
QLIRRAGEAALWSRGEERLDGRFPEIEHAALQLPDGTVIDGELLAWQPEQPLPMPFTALQTRIQRLKPGPKTLAAAPARV
VAYDLLELAGEDLRERPLQERRALLEGVLATLADPRIVASPLVQVSDWQAAAQVRVEARERGVEGLMLKRASSVYQSGRR
RGDWWKWKIDPLTIDAVLLYAQAGHGRRSTLYTDYTFGLWHEGQLVPIAKAYSGLDDKEILQLDRWIRANTTERFGPVRA
VTAHHVFELGFEAVNRSARHKSGIAVRFPRILRWRHDKPMAEADHLSTLQALAR

Sequences:

>Translated_534_residues
MKRFAALYRALDRSTGTLDKRAALVAYFRDAPALDAAWALYLLAGGKVASARMRIASSGELREWITDTAGVADWLVADSY
DHVGDLAETLALLLDDPVAEAADLPLAEWIEQRLLPIANQDVQVRKACIVQAWRSLAFDERLVFNKLLTGALRVGVSQRL
VQQALAELSGVDIARIAQRMLGSWRPHPTYLADLLTSEELPGDRQQPYPFFLASPLEAEVDTLGAIDDWLLEWKWDGIRL
QLIRRAGEAALWSRGEERLDGRFPEIEHAALQLPDGTVIDGELLAWQPEQPLPMPFTALQTRIQRLKPGPKTLAAAPARV
VAYDLLELAGEDLRERPLQERRALLEGVLATLADPRIVASPLVQVSDWQAAAQVRVEARERGVEGLMLKRASSVYQSGRR
RGDWWKWKIDPLTIDAVLLYAQAGHGRRSTLYTDYTFGLWHEGQLVPIAKAYSGLDDKEILQLDRWIRANTTERFGPVRA
VTAHHVFELGFEAVNRSARHKSGIAVRFPRILRWRHDKPMAEADHLSTLQALAR
>Mature_534_residues
MKRFAALYRALDRSTGTLDKRAALVAYFRDAPALDAAWALYLLAGGKVASARMRIASSGELREWITDTAGVADWLVADSY
DHVGDLAETLALLLDDPVAEAADLPLAEWIEQRLLPIANQDVQVRKACIVQAWRSLAFDERLVFNKLLTGALRVGVSQRL
VQQALAELSGVDIARIAQRMLGSWRPHPTYLADLLTSEELPGDRQQPYPFFLASPLEAEVDTLGAIDDWLLEWKWDGIRL
QLIRRAGEAALWSRGEERLDGRFPEIEHAALQLPDGTVIDGELLAWQPEQPLPMPFTALQTRIQRLKPGPKTLAAAPARV
VAYDLLELAGEDLRERPLQERRALLEGVLATLADPRIVASPLVQVSDWQAAAQVRVEARERGVEGLMLKRASSVYQSGRR
RGDWWKWKIDPLTIDAVLLYAQAGHGRRSTLYTDYTFGLWHEGQLVPIAKAYSGLDDKEILQLDRWIRANTTERFGPVRA
VTAHHVFELGFEAVNRSARHKSGIAVRFPRILRWRHDKPMAEADHLSTLQALAR

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=368, Percent_Identity=27.9891304347826, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71985269, Length=326, Percent_Identity=28.8343558282209, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320038, Length=361, Percent_Identity=26.5927977839335, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24762424, Length=334, Percent_Identity=26.9461077844311, Blast_Score=96, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 59895; Mature: 59895

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFAALYRALDRSTGTLDKRAALVAYFRDAPALDAAWALYLLAGGKVASARMRIASSGE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCH
LREWITDTAGVADWLVADSYDHVGDLAETLALLLDDPVAEAADLPLAEWIEQRLLPIANQ
HHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCCC
DVQVRKACIVQAWRSLAFDERLVFNKLLTGALRVGVSQRLVQQALAELSGVDIARIAQRM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGSWRPHPTYLADLLTSEELPGDRQQPYPFFLASPLEAEVDTLGAIDDWLLEWKWDGIRL
HHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHCCHHHHHHHEECCCCHH
QLIRRAGEAALWSRGEERLDGRFPEIEHAALQLPDGTVIDGELLAWQPEQPLPMPFTALQ
HHHHHHCHHHHHHCCHHHHCCCCCCCCHHEEECCCCCEECCCEEEECCCCCCCCCHHHHH
TRIQRLKPGPKTLAAAPARVVAYDLLELAGEDLRERPLQERRALLEGVLATLADPRIVAS
HHHHHHCCCCHHHHHCCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
PLVQVSDWQAAAQVRVEARERGVEGLMLKRASSVYQSGRRRGDWWKWKIDPLTIDAVLLY
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCEEHHHHHEE
AQAGHGRRSTLYTDYTFGLWHEGQLVPIAKAYSGLDDKEILQLDRWIRANTTERFGPVRA
HHCCCCCCCEEEEEEEECEECCCCEEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHH
VTAHHVFELGFEAVNRSARHKSGIAVRFPRILRWRHDKPMAEADHLSTLQALAR
HHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MKRFAALYRALDRSTGTLDKRAALVAYFRDAPALDAAWALYLLAGGKVASARMRIASSGE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCH
LREWITDTAGVADWLVADSYDHVGDLAETLALLLDDPVAEAADLPLAEWIEQRLLPIANQ
HHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCCC
DVQVRKACIVQAWRSLAFDERLVFNKLLTGALRVGVSQRLVQQALAELSGVDIARIAQRM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGSWRPHPTYLADLLTSEELPGDRQQPYPFFLASPLEAEVDTLGAIDDWLLEWKWDGIRL
HHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHCCHHHHHHHEECCCCHH
QLIRRAGEAALWSRGEERLDGRFPEIEHAALQLPDGTVIDGELLAWQPEQPLPMPFTALQ
HHHHHHCHHHHHHCCHHHHCCCCCCCCHHEEECCCCCEECCCEEEECCCCCCCCCHHHHH
TRIQRLKPGPKTLAAAPARVVAYDLLELAGEDLRERPLQERRALLEGVLATLADPRIVAS
HHHHHHCCCCHHHHHCCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
PLVQVSDWQAAAQVRVEARERGVEGLMLKRASSVYQSGRRRGDWWKWKIDPLTIDAVLLY
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCEEHHHHHEE
AQAGHGRRSTLYTDYTFGLWHEGQLVPIAKAYSGLDDKEILQLDRWIRANTTERFGPVRA
HHCCCCCCCEEEEEEEECEECCCCEEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHH
VTAHHVFELGFEAVNRSARHKSGIAVRFPRILRWRHDKPMAEADHLSTLQALAR
HHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA