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The map label for this gene is glnS [H]

Identifier: 78046486

GI number: 78046486

Start: 1057871

End: 1059610

Strand: Reverse

Name: glnS [H]

Synonym: XCV0930

Alternate gene names: 78046486

Gene position: 1059610-1057871 (Counterclockwise)

Preceding gene: 78046489

Following gene: 78046485

Centisome position: 20.46

GC content: 64.6

Gene sequence:

>1740_bases
ATGTCCGAGACCCTAGCCACCGACGCCACCGCCCCGGCGGAGAAGAAAGACTTCATCCGCCAGATCGTCCGCGAGGATCT
GGCCAGCGGCAAGCACACGGTCATCCGCACCCGCTTCCCGCCCGAGCCCAACGGCTACCTGCATATTGGCCATGCCAAGG
CGATCTGCCTGGATTTCGGCCTGGCGGCCGAGTTCGGCGGGCTGTGCAACCTGCGCCTGGACGATACCAACCCGGCCAAG
GAAGACCCCGAGTTCGTGGTGGCCATCCAGGACGACGTGCGCTGGCTGGGCTATGAGTGGGCACAACTGCGCCACGCCTC
GGATTATTTCCAGGTGTATTACCTGGCCGCGCAGAAGCTGATTCGCGATGGCCATGCGTTCGTGTGCGACCTGTCCGCAG
AACAGGTGCGCCAATACCGTGGCACGCTGACCGAGCCCGGCCGCAATTCGCCGTTCCGCGAGCGCAGCGTCGAAGAAAAC
CTGGAGCTGTTCGCACGCATGCGTGCCGGCGAATTCCCGGACGGCGCGCGCACGCTGCGCGCCAAGATCGACATGGCCAG
CGGCAACATCAACCTGCGCGACCCGGCGCTGTACCGCATCAAGCATGTGGAGCACCAGAACACCGGCAATGCGTGGCCGA
TCTACCCCATGTACGACTTCGCGCATTCGCTCGGCGATGCGGTGGAAGGCATCACCCACTCGCTGTGCACGCTGGAATTT
GAAGACCACCGCCCGCTGTACGACTGGTGCGTGGACAAGGTGGACCTGGCCGGTCACCCGGAACTGCTGCAGCCGCTGCT
GGACAAGGGCTTACCGCGCGAAGCGGCCAAGCCGCGTCAGATCGAGTTTTCGCGCCTCAACATCAACTACACGGTGATGA
GCAAGCGCAAGCTCACCGCGCTGGTGGAAGAGCAGCTGGTGGACGGTTGGGACGACCCGCGCATGTACACGCTGCAGGGC
CTGCGCCGGCGTGGCTATACGCCGGCGGCGATGCGGTTGTTCGTGGACCGCGTGGGCATCAGCAAGCAGAACTCGCTGAT
CGATTTCTCGGTGCTGGAAGGGTGCCTGCGCGAGGATCTGGACGCCGCGGCGCCGCGCCGCATGGCAGTGATCGACCCGC
TCAAGCTGGTGCTGACCAACCTGCCGGAAGGCCATACCGAAACGCTGCAGTTTTCCAACCACCCCAAGGACGAGAGCTTC
GGCACACGCGAAGTACCGTTTGCGCGCGAGCTGTGGATCGAACGCGAGGATTTTGCCGAGGTTCCGCCCAAGGGCTGGAA
GCGCCTGGTGCCGGGCGGCGAAATCCGCTTGCGCGGCGCAGGCATTGCGCGCGTGGACGAGGTGATCAAGAACGCTGACG
GCGAGATCGTCGAACTGCGCGGCTGGCTCGATCCGGAATCGCGTCCGGGCATGGAAGGCGCCAACCGCAAGGTCAAGGGC
ACCATCCACTGGGTCAGCGCCGTACACGCGGTGGAAGCGGAAATCCGCCTGTACGACCGCCTGTTTTCGGTGGAAAAGCC
CGACGACGAATCCGAAGGCAAGACCTACCGCGATTATCTGAACCCCGAGTCCAAGCGCAACGTGCGCGGCTACGTGGAGC
CGAGCGCTGCGATGGCTGCGCCGGAGCAGGCGTTCCAGTTCGAACGCAGCGGTTACTTCGTTGCCGACCGTCGCGACCAT
AGCGCGGCCACGCCGGTCTTCAATCGCAGCGTGACCTTGCGCGATACCTGGGCCAAGTAA

Upstream 100 bases:

>100_bases
CGCGCAAACCAACGCCCGGAAGCCGCCCCGCCGCGCCGCGCGCCTACCCCTAATCGGTGCCACCGCCTAAACTTGCGGTT
TACCCATTGCTGATGCGCGC

Downstream 100 bases:

>100_bases
CCACGCAGGACAGACAGCGGCGCTCTTGCAAGGCGGGCGTCGCTGCTCCCTAGGTTGGGCGGCGGCTGCACGGCTGCAGA
GGCCGCACCTGCGTCGTCAC

Product: glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamine--tRNA ligase; GlnRS [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFGLAAEFGGLCNLRLDDTNPAK
EDPEFVVAIQDDVRWLGYEWAQLRHASDYFQVYYLAAQKLIRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEEN
LELFARMRAGEFPDGARTLRAKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EDHRPLYDWCVDKVDLAGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTALVEEQLVDGWDDPRMYTLQG
LRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDLDAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDESF
GTREVPFARELWIEREDFAEVPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
TIHWVSAVHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAAPEQAFQFERSGYFVADRRDH
SAATPVFNRSVTLRDTWAK

Sequences:

>Translated_579_residues
MSETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFGLAAEFGGLCNLRLDDTNPAK
EDPEFVVAIQDDVRWLGYEWAQLRHASDYFQVYYLAAQKLIRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEEN
LELFARMRAGEFPDGARTLRAKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EDHRPLYDWCVDKVDLAGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTALVEEQLVDGWDDPRMYTLQG
LRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDLDAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDESF
GTREVPFARELWIEREDFAEVPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
TIHWVSAVHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAAPEQAFQFERSGYFVADRRDH
SAATPVFNRSVTLRDTWAK
>Mature_578_residues
SETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFGLAAEFGGLCNLRLDDTNPAKE
DPEFVVAIQDDVRWLGYEWAQLRHASDYFQVYYLAAQKLIRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEENL
ELFARMRAGEFPDGARTLRAKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEFE
DHRPLYDWCVDKVDLAGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTALVEEQLVDGWDDPRMYTLQGL
RRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDLDAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDESFG
TREVPFARELWIEREDFAEVPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKGT
IHWVSAVHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAAPEQAFQFERSGYFVADRRDHS
AATPVFNRSVTLRDTWAK

Specific function: Unknown

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI4826960, Length=545, Percent_Identity=43.1192660550459, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI62241042, Length=555, Percent_Identity=32.7927927927928, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1786895, Length=572, Percent_Identity=55.0699300699301, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1788743, Length=107, Percent_Identity=33.6448598130841, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17543332, Length=553, Percent_Identity=41.5913200723327, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17511007, Length=535, Percent_Identity=31.9626168224299, Blast_Score=248, Evalue=9e-66,
Organism=Saccharomyces cerevisiae, GI6324742, Length=583, Percent_Identity=36.0205831903945, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6321192, Length=534, Percent_Identity=32.7715355805243, Blast_Score=272, Evalue=1e-73,
Organism=Drosophila melanogaster, GI17864488, Length=565, Percent_Identity=39.2920353982301, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24649466, Length=538, Percent_Identity=32.7137546468402, Blast_Score=253, Evalue=3e-67,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR004514
- InterPro:   IPR022861
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C [H]

EC number: =6.1.1.18 [H]

Molecular weight: Translated: 65843; Mature: 65712

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00435 PEROXIDASE_1 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCEEEEEHHC
LAAEFGGLCNLRLDDTNPAKEDPEFVVAIQDDVRWLGYEWAQLRHASDYFQVYYLAAQKL
HHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEENLELFARMRAGEFPDGARTLR
HHCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEE
AKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
EDHRPLYDWCVDKVDLAGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTA
CCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCHHHHH
LVEEQLVDGWDDPRMYTLQGLRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDL
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHH
DAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDESFGTREVPFARELWIEREDFAE
HHCCCCCEEHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHC
VPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
CCCHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEE
TIHWVSAVHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAA
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCEEECCHHHHCC
PEQAFQFERSGYFVADRRDHSAATPVFNRSVTLRDTWAK
CHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCEEEEEHHC
LAAEFGGLCNLRLDDTNPAKEDPEFVVAIQDDVRWLGYEWAQLRHASDYFQVYYLAAQKL
HHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEENLELFARMRAGEFPDGARTLR
HHCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEE
AKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
EDHRPLYDWCVDKVDLAGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTA
CCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCHHHHH
LVEEQLVDGWDDPRMYTLQGLRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDL
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHH
DAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDESFGTREVPFARELWIEREDFAE
HHCCCCCEEHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHC
VPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
CCCHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEE
TIHWVSAVHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAA
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCEEECCHHHHCC
PEQAFQFERSGYFVADRRDHSAATPVFNRSVTLRDTWAK
CHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]