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The map label for this gene is envZ [H]

Identifier: 78046339

GI number: 78046339

Start: 895959

End: 897461

Strand: Reverse

Name: envZ [H]

Synonym: XCV0783

Alternate gene names: 78046339

Gene position: 897461-895959 (Counterclockwise)

Preceding gene: 78046340

Following gene: 78046336

Centisome position: 17.33

GC content: 68.66

Gene sequence:

>1503_bases
GTGAGCAAACCGGCACGGCGCGGGCTGTCGATCTTTGCGCGGACCTTTGTGTTGTTGGCGGTGGCCCTGGTCACCGCCCA
GGCGGTGGGCATCGCCCTGTTGATGATGCGTACCCCCGTCTACGAGCCTCCGGTCCATCCGCCGGAAGTGGTGGCGCTGC
TCTCCACCCGCATGCCGGCCGGTACCCAAACCCTGAAAGTGCACGAATCGGCGCAAGCCCCGGTGCCGCCGACAGGCCAG
GTGCGCGACCCCTTCGCCGAAATGCTGCTTGCGCACTGGCTGGACGTGCCCGAACGCCAGGTGCGGTTCTACCGCAACGC
CAATGATCGTGAAGGCCCCCAGCCAGGCATGCTGCCGCCGCAGCGGTGGTCCAACCAGAACCACGCGGGCGAAGGCGGTG
ACGGGGCGCACGAACGCCCTGGCACGCAACCTCTGCCGCCGTTTCCGGACGACTGGCCGCGTGACGGCCACCATGCTGCG
CTGCCCGGCGACGGGCTGCGCCCGGACGAGTTGCCCGGCGCCTGGGAAAGCGAGCGCCTGACCCCCGGCGTACCGCTGCT
GGACGGCTTCACCGCCGCCCTGCAACAACCCGATGGCCGTTGGCGTACGGTGGAATCGCCGCGTCGACGCCTCTCGGGCG
AGTTCAAGACCCACGTCGTGCTGCTGTTCCTGGCCGGCCTGCTGGCCAACGTGCCGCTGGCATGGTGGTTTTCGCGCGCG
CTGTCGGCACCGATCAAGCGCTTTGCCGAAGCTGCCGACCGCCTGGGCCGGAATCCCGATGCCGCCGCCCTGCAACGCAG
CGGCCCGCCGGAAATCGTGCGCGCAGCCGATTCGTTCAACGCGATGCAGGCGCGCCTGAACCGCCTGATCAACGAACGCA
CGCACATGGTCGCAGCGATCGCGCACGACCTGCGCACGCCGCTGGCGCGGCTGTCGTTTCGTCTGGATGGCCTGCAGCCA
CCGCTGCGCGACAAGGCGCTGGCCGATATCAACGAAATGAAGGCGATGATTTCCGCAGCGCTGGACTTCATCCAGAACGA
TCGTCATCGCGGCGAGCGCGCGCCGCTGGATCTGCGCTTGCTGGTGGAGAGCGTGGTGGACAACGCCACCGATATCGGCG
CCGACGCCGAGCTGCTGCCCGGCCCGGAAATCACCCTGGACGGCGACCCGCTGGCGTTGCGCCGCGCGGTCATGAATCTG
CTCGAAAACGCGTTGAAGTACGGCAAGCGCGCCCGTCTGCAACTGCAGCGCGATGGCGAGGACGGCGTGTTGTGGATCGA
CGACGACGGCCCCGGCATCGACCCGACCCAGCGCGAACAATTGTTGCTGCCGTTCGTGCGTGGCGAGTCTTCGCGCAATC
GCGACACCGGCGGCATCGGGCTGGGTTTGTCGGTGGCGCACAGCATCGTGCTGGCGCACGGCGGCGACCTACGCCTGGAC
AATCGCCCGCGTGGCGGCTTGCGCGTGACCGTACGACTGCCCTGCATGCCCGAGCGGCGCTGA

Upstream 100 bases:

>100_bases
TCAGCCGCCTGCGCCGCAAAATCAATGAGCGCGTCCATACCGAGTTGATTCGCACCGTACGCAACGAGGGCTACATGCTG
CTGCCGAGCGTCTCGCGCCT

Downstream 100 bases:

>100_bases
CGTGTGATGGAGTGCGGCCTGCCGGGCCGGGCAAGCGGCAGCTGTCATGATCCGAGCCCACCACCGCTGTTCCGGCCATG
GCCTTGCGCGTCTGGCGACA

Product: EnvZ family two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSKPARRGLSIFARTFVLLAVALVTAQAVGIALLMMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHESAQAPVPPTGQ
VRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPPQRWSNQNHAGEGGDGAHERPGTQPLPPFPDDWPRDGHHAA
LPGDGLRPDELPGAWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWWFSRA
LSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLDGLQP
PLRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRAVMNL
LENALKYGKRARLQLQRDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGDLRLD
NRPRGGLRVTVRLPCMPERR

Sequences:

>Translated_500_residues
MSKPARRGLSIFARTFVLLAVALVTAQAVGIALLMMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHESAQAPVPPTGQ
VRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPPQRWSNQNHAGEGGDGAHERPGTQPLPPFPDDWPRDGHHAA
LPGDGLRPDELPGAWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWWFSRA
LSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLDGLQP
PLRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRAVMNL
LENALKYGKRARLQLQRDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGDLRLD
NRPRGGLRVTVRLPCMPERR
>Mature_499_residues
SKPARRGLSIFARTFVLLAVALVTAQAVGIALLMMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHESAQAPVPPTGQV
RDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPPQRWSNQNHAGEGGDGAHERPGTQPLPPFPDDWPRDGHHAAL
PGDGLRPDELPGAWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWWFSRAL
SAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLDGLQPP
LRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRAVMNLL
ENALKYGKRARLQLQRDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGDLRLDN
RPRGGLRVTVRLPCMPERR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=282, Percent_Identity=32.6241134751773, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1787894, Length=259, Percent_Identity=33.5907335907336, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1790346, Length=294, Percent_Identity=30.6122448979592, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=30.03663003663, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786783, Length=271, Percent_Identity=29.520295202952, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=26.171875, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1790551, Length=243, Percent_Identity=30.8641975308642, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=31.5068493150685, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=417, Percent_Identity=24.220623501199, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081816, Length=111, Percent_Identity=36.036036036036, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=25.7510729613734, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788713, Length=259, Percent_Identity=23.9382239382239, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=303, Percent_Identity=24.7524752475248, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=25.7918552036199, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54996; Mature: 54864

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPARRGLSIFARTFVLLAVALVTAQAVGIALLMMRTPVYEPPVHPPEVVALLSTRMPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
GTQTLKVHESAQAPVPPTGQVRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPP
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCC
QRWSNQNHAGEGGDGAHERPGTQPLPPFPDDWPRDGHHAALPGDGLRPDELPGAWESERL
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWWFSRA
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
LSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAI
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHDLRTPLARLSFRLDGLQPPLRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LVESVVDNATDIGADAELLPGPEITLDGDPLALRRAVMNLLENALKYGKRARLQLQRDGE
HHHHHHCCHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGDLRLD
CCEEEECCCCCCCCCCCHHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEC
NRPRGGLRVTVRLPCMPERR
CCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
SKPARRGLSIFARTFVLLAVALVTAQAVGIALLMMRTPVYEPPVHPPEVVALLSTRMPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
GTQTLKVHESAQAPVPPTGQVRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPP
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCC
QRWSNQNHAGEGGDGAHERPGTQPLPPFPDDWPRDGHHAALPGDGLRPDELPGAWESERL
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWWFSRA
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
LSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAI
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHDLRTPLARLSFRLDGLQPPLRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LVESVVDNATDIGADAELLPGPEITLDGDPLALRRAVMNLLENALKYGKRARLQLQRDGE
HHHHHHCCHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGDLRLD
CCEEEECCCCCCCCCCCHHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEC
NRPRGGLRVTVRLPCMPERR
CCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]