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The map label for this gene is oprN2 [H]

Identifier: 78046019

GI number: 78046019

Start: 522714

End: 524222

Strand: Reverse

Name: oprN2 [H]

Synonym: XCV0463

Alternate gene names: 78046019

Gene position: 524222-522714 (Counterclockwise)

Preceding gene: 78046026

Following gene: 78046016

Centisome position: 10.12

GC content: 69.25

Gene sequence:

>1509_bases
ATGTCGTCACTCCGCACCCTCGCAGTGTTCGTTGCCGCCAGCCTTGTCGCAGGTTGCGCGGTTGGTCCCGACTACGCCCG
GCCGGAGGTGCCGCTGCCGGACCGCTACATCGGCCAGGCGGATATCGCGCAGCGCCAGGCCGCAGTGCCAGCCGACCTGT
CGACCTGGTGGGACGGCTTCAACGATCCCGACCTGAGCCGCTACGTCACGGCTGCGCTGGCGCAAAACCTGGACCTGGCC
CAGGCCGGCGCACGCGTGGCCCAGGCGCGCGCCGGGCTGAGTGCCGCCACCGCGGCGCTGCTACCAGCGGGCAACGTGAG
CGGCAGCGCCACGCGTGCCTACCAATCGCTGGAAACCCCATTGGGCCAGGTGATCAGCAGCACGCCCAACTTCGACCGCC
ATGCCAGCGTGTACGAAGCCAACCTGGGCGCCAGCTGGGAACTGGATCTGTTCGGGGGCCTGCGCCGCGGCCGCCAGGCG
GCCTTGGCCGATTACCAGGCCACCGAAGCAGGTGCTGCTGCCACACGTCTGGCAGTGGCCGCGCAGACCGCCGATATCTA
CATCAGCATCCGCGGCCTCCAGGCGCGGCTGGACGTGGCGCAGCGCCAGGTGGCCACCCAGCGGGGCCTGCTCTCGATGG
TGACGCTGCTGCACGGCAAAGGCCTTGCCGCCGAACTGCAGTTGCAGCAGGCCCAGGGCGCACTCGCGCAGGCGCAGGCC
GGCGTACCCGGCCTGGAAGCCGGCCTGGTTGCGGCAATGAACGCGCTGGACGTGATGCTTGGCGTGCCGCCCGGCACGCA
CCGTGCCGAGCTGTCGGCGACCAAACCCATTCCGCCAGCCCCCCAGATCGCCGACAGCGGCACCCCCGGCGACCTGCTAC
GGCGCCGGCCCGACCTGATCGTGGCCGAGCGTCGGCTGGCCGCCTCCAATGCGCGTATCGGCGTGGCGATGGCCGAGTAC
TACCCCAAGTTTTCGCTCAGCGGCCTGCTTGGCAGCGCCACCGCCATCTCCGGTGCGAACCTGTTTACCGGCGACGCCGC
GCAGTCGTCCGGCGTACTCGGCCTGCGCTGGCGGCTGTTCGACTTCGGCCGCATCAACGCACAGATCGCACAGGCCAAAG
GCCAGCAAGCCGAACAACTCGCGGCTTATCGCCTTGCGGTATTGCGCGCCACCGAAGATGTCGAAAATGCATTCACCGCA
CTGATCAAACGCGAGCAGCAGGCAGCGGTGCTGACGCAGGGCGTGGATGCACTCGGCAAGGCGCGCGGCGCCTCTGCGCT
GGCCTACGAAAAAGGCACGGTGAGCCTGATCGAAGTGCTCAACGCCGACGACAGCCTGCTACGCGCCTCCGACGCGCAAG
TGCAGGCGCGTACCGACGCGGCGCGCAGCGCGGTTGCGACCTTCAAGGCGCTGGGCGGCGGTTGGCAGGCCGGCGGTGCG
GGTCCTGCTGCGATCGCTGTCGCCGTGGACAGCAACCGTCACCAAGACGACACGACAGCAACTAAGTGA

Upstream 100 bases:

>100_bases
TGCTTTGCTCATCGCGAAAGCTTAGCGCCGTCGTTGCCGACTTACAAAAGTGACTATTTCGTATTACAGTCACTTACCAC
TTGTCATTCCGGCCCCGCCC

Downstream 100 bases:

>100_bases
ATGACACGCCACGCTGACGTTGATGGGCGTCTGCGCAGGTGGCACGCCACCGCTACCGATGTCGCCGGCTACACGTAACC
GCAAGAGCTGGCCGACAGGG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSSLRTLAVFVAASLVAGCAVGPDYARPEVPLPDRYIGQADIAQRQAAVPADLSTWWDGFNDPDLSRYVTAALAQNLDLA
QAGARVAQARAGLSAATAALLPAGNVSGSATRAYQSLETPLGQVISSTPNFDRHASVYEANLGASWELDLFGGLRRGRQA
ALADYQATEAGAAATRLAVAAQTADIYISIRGLQARLDVAQRQVATQRGLLSMVTLLHGKGLAAELQLQQAQGALAQAQA
GVPGLEAGLVAAMNALDVMLGVPPGTHRAELSATKPIPPAPQIADSGTPGDLLRRRPDLIVAERRLAASNARIGVAMAEY
YPKFSLSGLLGSATAISGANLFTGDAAQSSGVLGLRWRLFDFGRINAQIAQAKGQQAEQLAAYRLAVLRATEDVENAFTA
LIKREQQAAVLTQGVDALGKARGASALAYEKGTVSLIEVLNADDSLLRASDAQVQARTDAARSAVATFKALGGGWQAGGA
GPAAIAVAVDSNRHQDDTTATK

Sequences:

>Translated_502_residues
MSSLRTLAVFVAASLVAGCAVGPDYARPEVPLPDRYIGQADIAQRQAAVPADLSTWWDGFNDPDLSRYVTAALAQNLDLA
QAGARVAQARAGLSAATAALLPAGNVSGSATRAYQSLETPLGQVISSTPNFDRHASVYEANLGASWELDLFGGLRRGRQA
ALADYQATEAGAAATRLAVAAQTADIYISIRGLQARLDVAQRQVATQRGLLSMVTLLHGKGLAAELQLQQAQGALAQAQA
GVPGLEAGLVAAMNALDVMLGVPPGTHRAELSATKPIPPAPQIADSGTPGDLLRRRPDLIVAERRLAASNARIGVAMAEY
YPKFSLSGLLGSATAISGANLFTGDAAQSSGVLGLRWRLFDFGRINAQIAQAKGQQAEQLAAYRLAVLRATEDVENAFTA
LIKREQQAAVLTQGVDALGKARGASALAYEKGTVSLIEVLNADDSLLRASDAQVQARTDAARSAVATFKALGGGWQAGGA
GPAAIAVAVDSNRHQDDTTATK
>Mature_501_residues
SSLRTLAVFVAASLVAGCAVGPDYARPEVPLPDRYIGQADIAQRQAAVPADLSTWWDGFNDPDLSRYVTAALAQNLDLAQ
AGARVAQARAGLSAATAALLPAGNVSGSATRAYQSLETPLGQVISSTPNFDRHASVYEANLGASWELDLFGGLRRGRQAA
LADYQATEAGAAATRLAVAAQTADIYISIRGLQARLDVAQRQVATQRGLLSMVTLLHGKGLAAELQLQQAQGALAQAQAG
VPGLEAGLVAAMNALDVMLGVPPGTHRAELSATKPIPPAPQIADSGTPGDLLRRRPDLIVAERRLAASNARIGVAMAEYY
PKFSLSGLLGSATAISGANLFTGDAAQSSGVLGLRWRLFDFGRINAQIAQAKGQQAEQLAAYRLAVLRATEDVENAFTAL
IKREQQAAVLTQGVDALGKARGASALAYEKGTVSLIEVLNADDSLLRASDAQVQARTDAARSAVATFKALGGGWQAGGAG
PAAIAVAVDSNRHQDDTTATK

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=476, Percent_Identity=26.0504201680672, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI2367348, Length=499, Percent_Identity=24.4488977955912, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51975; Mature: 51844

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLRTLAVFVAASLVAGCAVGPDYARPEVPLPDRYIGQADIAQRQAAVPADLSTWWDGF
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHCCC
NDPDLSRYVTAALAQNLDLAQAGARVAQARAGLSAATAALLPAGNVSGSATRAYQSLETP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LGQVISSTPNFDRHASVYEANLGASWELDLFGGLRRGRQAALADYQATEAGAAATRLAVA
HHHHHHCCCCCCCCCCEEECCCCCCEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHE
AQTADIYISIRGLQARLDVAQRQVATQRGLLSMVTLLHGKGLAAELQLQQAQGALAQAQA
EEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GVPGLEAGLVAAMNALDVMLGVPPGTHRAELSATKPIPPAPQIADSGTPGDLLRRRPDLI
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCE
VAERRLAASNARIGVAMAEYYPKFSLSGLLGSATAISGANLFTGDAAQSSGVLGLRWRLF
EHHHHHHHCCCCEEEEHHHHCCCCCHHHHHCCHHHCCCCCEEECCCCCCCCEEEEEEEEE
DFGRINAQIAQAKGQQAEQLAAYRLAVLRATEDVENAFTALIKREQQAAVLTQGVDALGK
ECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARGASALAYEKGTVSLIEVLNADDSLLRASDAQVQARTDAARSAVATFKALGGGWQAGGA
HCCCCEEEECCCCHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GPAAIAVAVDSNRHQDDTTATK
CCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SSLRTLAVFVAASLVAGCAVGPDYARPEVPLPDRYIGQADIAQRQAAVPADLSTWWDGF
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHCCC
NDPDLSRYVTAALAQNLDLAQAGARVAQARAGLSAATAALLPAGNVSGSATRAYQSLETP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LGQVISSTPNFDRHASVYEANLGASWELDLFGGLRRGRQAALADYQATEAGAAATRLAVA
HHHHHHCCCCCCCCCCEEECCCCCCEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHE
AQTADIYISIRGLQARLDVAQRQVATQRGLLSMVTLLHGKGLAAELQLQQAQGALAQAQA
EEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GVPGLEAGLVAAMNALDVMLGVPPGTHRAELSATKPIPPAPQIADSGTPGDLLRRRPDLI
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCE
VAERRLAASNARIGVAMAEYYPKFSLSGLLGSATAISGANLFTGDAAQSSGVLGLRWRLF
EHHHHHHHCCCCEEEEHHHHCCCCCHHHHHCCHHHCCCCCEEECCCCCCCCEEEEEEEEE
DFGRINAQIAQAKGQQAEQLAAYRLAVLRATEDVENAFTALIKREQQAAVLTQGVDALGK
ECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARGASALAYEKGTVSLIEVLNADDSLLRASDAQVQARTDAARSAVATFKALGGGWQAGGA
HCCCCEEEECCCCHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GPAAIAVAVDSNRHQDDTTATK
CCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]