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The map label for this gene is ilvD [H]

Identifier: 78045913

GI number: 78045913

Start: 408308

End: 410146

Strand: Reverse

Name: ilvD [H]

Synonym: XCV0357

Alternate gene names: 78045913

Gene position: 410146-408308 (Counterclockwise)

Preceding gene: 78045916

Following gene: 78045911

Centisome position: 7.92

GC content: 64.98

Gene sequence:

>1839_bases
ATGCCCGAGTACCGCTCCAAGACCTCCACCCACGGCCGCAACATGGCCGGCGCCCGCGCCCTGTGGCGTGCCACCGGCAT
GCGCGATGGCGACTTCCACAAGCCCATCATCGCTATCGCCAACTCGTTCACGCAGTTCGTGCCCGGGCATGTGCATTTGA
AGGATCTTGGTCAGCTGGTCGCGCGCGAGATCGAACGCGTCGGCGGCGTGGCCAAGGAGTTCGACACCATCGCCGTGGAT
GACGGCATCGCGATGGGCCACGACGGCATGCTGTATTCGTTGCCAAGCCGCGAGATCATCGCCGATTCGGTCGAATACAT
GGTCAACGCGCATTGCGCCGACGCGCTGGTGTGCATTTCCAATTGCGACAAGATCACCCCCGGCATGTTGATGGCCGCGC
TACGGCTCAACATCCCCACCGTGTTCGTTTCCGGCGGCCCGATGGAAGCCGGCAAGACCAAGCTGGCCGAGCACAAGCTC
GACCTGATCGACGCGATGGTGATCGCCGCCGACGACAGCGCCTCCGACGAAAAGGTGGCCGAGTTCGAGCGCAGCGCCTG
CCCCACCTGCGGCTCGTGCTCGGGCATGTTCACTGCCAACTCGATGAACTGCCTGACCGAAGCGCTGGGCCTGTCGCTGC
CCGGCAACGGCACGGTTGTGGCCACGCACGCCGACCGCGAACAACTGTTCCTGCGCGCCGGACGCGTGGCGGTGGAACTG
TGTCACCGCTGGTACGGCGGCGAAGATCCCACTGCCCTGCCGCGCGGCATCGCCACCTTCGAAGCCTTCGAAAATGCGAT
GACGCTGGATATCGCCATGGGTGGCTCGACCAACACCATCCTGCACCTGCTCGCCGCCGCGCAGGAAGGCGAGGTTGCCT
TCGGCATGCACGATATCGACCGCCTGTCCAAGCGCGTGCCGCAGCTGTGCAAGGTCGCGCCGAATACGCCCAAGTACCAC
ATCGAAGACGTGCATCGCGCCGGCGGCATCATGGCCATTCTCGGCGAGCTGGCACGTGGTGGCCTGCTGCATACTAACGC
CGCCACCGTGCACGCACGCACGCTGGCCGAGGCCATCGCGCAATGGGATGTCACCCAGACCGACGATGAAACAGTACACA
CGTTCTACAAAGCCGGCCCGGCCGGCATTCCCACGCAGATCGCCTTCAGCCAGGCCACGCGCTGGGACAGCCTGGATACC
GACCGCAGCGAGGGCTGCATCCGCGATATCGCACACGCGTTCTCGCAGGAAGGCGGCCTGGCCGTGCTGTACGGCAATAT
CGCCCGCGACGGCTGCGTGGTGAAAACTGCAGGCGTGGACGAATCCATCCACGTATTCGAAGGCACGGCCCGCGTGTTCG
AGAGCCAGGATGCAGCAGTCAAGGGCATCCTTGCCGATGAGGTGGTTGCGGGGGACGTGGTGGTCATCCGCTACGAGGGC
CCCAAGGGCGGCCCCGGCATGCAGGAAATGCTCTACCCCACCAGCTATCTCAAATCCAAGGGCCTGGGCAAACAATGCGC
CCTGCTCACCGACGGCCGCTTCTCCGGCGGCACCTCGGGGTTATCGATCGGCCACGCATCGCCGGAAGCCGCCGCAGGCG
GCGCGATCGGCCTGGTGCGCGACGGCGACAGGATCCTGATCGACATTCCCAAGCGCTCGATCAACCTGCTGATCTCGGAC
GAGGAACTCGCCCTTCGTCGTGCCGAGCAAGATGCCAAGGGCTGGAAGCCGGTGGAAGTGCGCCCCCGCAAGGTCACTAC
TGCATTGAAGGCGTACGCGTTGCTGGCGACCAGTGCGGACAAGGGTGCGGTGCGGGACAAGGCATTGTTGGACGGCTAG

Upstream 100 bases:

>100_bases
ACCGTGCGGACCCTGCGCGTGCGGCGACGGTTGCAGCAGCAACAGTCACGACGCGCTCTAATTGCCAGCCACCGCTCGCC
AATCAGCCGTCGAATTCGCC

Downstream 100 bases:

>100_bases
GGACAGCGAGCGCAGCGTGGCCAGCTGGTTTCGGATGGCCAGCGCGGTGCAACGCATTCGGTGGAACATGCTGATGCAAC
GCAGTCATCGCAACTTGCCT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKL
DLIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMHDIDRLSKRVPQLCKVAPNTPKYH
IEDVHRAGGIMAILGELARGGLLHTNAATVHARTLAEAIAQWDVTQTDDETVHTFYKAGPAGIPTQIAFSQATRWDSLDT
DRSEGCIRDIAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDRILIDIPKRSINLLISD
EELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKALLDG

Sequences:

>Translated_612_residues
MPEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKL
DLIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMHDIDRLSKRVPQLCKVAPNTPKYH
IEDVHRAGGIMAILGELARGGLLHTNAATVHARTLAEAIAQWDVTQTDDETVHTFYKAGPAGIPTQIAFSQATRWDSLDT
DRSEGCIRDIAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDRILIDIPKRSINLLISD
EELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKALLDG
>Mature_611_residues
PEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKLD
LIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVELC
HRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMHDIDRLSKRVPQLCKVAPNTPKYHI
EDVHRAGGIMAILGELARGGLLHTNAATVHARTLAEAIAQWDVTQTDDETVHTFYKAGPAGIPTQIAFSQATRWDSLDTD
RSEGCIRDIAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEGP
KGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDRILIDIPKRSINLLISDE
ELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKALLDG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=72.2852512155592, Blast_Score=921, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=518, Percent_Identity=32.046332046332, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786464, Length=551, Percent_Identity=31.3974591651543, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=30.2411873840445, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=37.3770491803279, Blast_Score=354, Evalue=3e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65173; Mature: 65042

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERVGGVAKEFDTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKLDLIDAMVIAADDSASDEKVA
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHH
EFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMHDID
HHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEECHHHHH
RLSKRVPQLCKVAPNTPKYHIEDVHRAGGIMAILGELARGGLLHTNAATVHARTLAEAIA
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
QWDVTQTDDETVHTFYKAGPAGIPTQIAFSQATRWDSLDTDRSEGCIRDIAHAFSQEGGL
HCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCE
AVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
EEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHEEECCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGDRILIDIPKRSINLLISDEELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSAD
CCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCC
KGAVRDKALLDG
CCCCCCHHHCCC
>Mature Secondary Structure 
PEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERVGGVAKEFDTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKLDLIDAMVIAADDSASDEKVA
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHH
EFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMHDID
HHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEECHHHHH
RLSKRVPQLCKVAPNTPKYHIEDVHRAGGIMAILGELARGGLLHTNAATVHARTLAEAIA
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
QWDVTQTDDETVHTFYKAGPAGIPTQIAFSQATRWDSLDTDRSEGCIRDIAHAFSQEGGL
HCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCE
AVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
EEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHEEECCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGDRILIDIPKRSINLLISDEELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSAD
CCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCC
KGAVRDKALLDG
CCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]