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The map label for this gene is yedX [C]

Identifier: 78045859

GI number: 78045859

Start: 348536

End: 348895

Strand: Reverse

Name: yedX [C]

Synonym: XCV0303

Alternate gene names: 78045859

Gene position: 348895-348536 (Counterclockwise)

Preceding gene: 78045860

Following gene: 78045858

Centisome position: 6.74

GC content: 70.56

Gene sequence:

>360_bases
ATGGCCGCAACCCACCCAGGCAGTGGCATGAGCACGCTGTCCACGCACGTGCTGGACACCGCCAGCGGCCGCCCCGCCGC
GGGCGTGCCGCTGCGGCTGTTCGCCGGCGAGACGCTGCACTTCGAGGGTGTCACCAATCCCGACGGCCGCTGCCCGGACC
TGGCCGCGCTCGCGCTGCAACCCGGCCGCTACCGGCTGGAATTCGACCTCGCCCGCTATTGGCAGGCAACCGGCATGGCG
CTGGCCGATCCACCGTTCCTGGACTGCATCCCGATCGCCTTCGGCATCGCCGACGACGGCCACTACCATGTCCCGCTGCT
GCTGTCCCCGTACGGGTACTCCACCTATCGCGGCAGCTGA

Upstream 100 bases:

>100_bases
CGCGGCTGGCCCGCGCAGTGGCCGACCAGTTGTTCCTGGACGACCGCCAGGCCATCGTCGACAGCTACCTGGCCTACGAC
CAACCCGAATTCGTCGGCCA

Downstream 100 bases:

>100_bases
GCGCTGCGTCGTGCCGCAGTGCAGGCAATTCGGGCCCGTCTGCACGACGGCCTGCGCTTCCATCGCTGCCGGTGCGCATG
ACCCCCTGCGCACGGTGTCA

Product: transthyretin-like protein

Products: NA

Alternate protein names: HIU hydrolase; HIUHase [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MAATHPGSGMSTLSTHVLDTASGRPAAGVPLRLFAGETLHFEGVTNPDGRCPDLAALALQPGRYRLEFDLARYWQATGMA
LADPPFLDCIPIAFGIADDGHYHVPLLLSPYGYSTYRGS

Sequences:

>Translated_119_residues
MAATHPGSGMSTLSTHVLDTASGRPAAGVPLRLFAGETLHFEGVTNPDGRCPDLAALALQPGRYRLEFDLARYWQATGMA
LADPPFLDCIPIAFGIADDGHYHVPLLLSPYGYSTYRGS
>Mature_118_residues
AATHPGSGMSTLSTHVLDTASGRPAAGVPLRLFAGETLHFEGVTNPDGRCPDLAALALQPGRYRLEFDLARYWQATGMAL
ADPPFLDCIPIAFGIADDGHYHVPLLLSPYGYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=119, Percent_Identity=36.9747899159664, Blast_Score=67, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115532920, Length=125, Percent_Identity=35.2, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115532922, Length=125, Percent_Identity=35.2, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115534555, Length=118, Percent_Identity=38.135593220339, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652571, Length=117, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 12704; Mature: 12573

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00092 N6_MTASE ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATHPGSGMSTLSTHVLDTASGRPAAGVPLRLFAGETLHFEGVTNPDGRCPDLAALALQ
CCCCCCCCCCCHHHHHEEECCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCEEEEEEC
PGRYRLEFDLARYWQATGMALADPPFLDCIPIAFGIADDGHYHVPLLLSPYGYSTYRGS
CCCEEEEEHHHHHHHHCCCEECCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AATHPGSGMSTLSTHVLDTASGRPAAGVPLRLFAGETLHFEGVTNPDGRCPDLAALALQ
CCCCCCCCCCHHHHHEEECCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCEEEEEEC
PGRYRLEFDLARYWQATGMALADPPFLDCIPIAFGIADDGHYHVPLLLSPYGYSTYRGS
CCCEEEEEHHHHHHHHCCCEECCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]