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The map label for this gene is acdA [H]

Identifier: 78045829

GI number: 78045829

Start: 319340

End: 320503

Strand: Reverse

Name: acdA [H]

Synonym: XCV0273

Alternate gene names: 78045829

Gene position: 320503-319340 (Counterclockwise)

Preceding gene: 78045833

Following gene: 78045828

Centisome position: 6.19

GC content: 65.55

Gene sequence:

>1164_bases
ATGCATGTGCCGTCCTTGAACTTCGAGCTTGGCGAAGAGATCGACCTGCTGCGCGAAAGCGTGGCCGCCTTCGCCAGCCA
CCATATCGCTCCGCTGGCCGCGGCAGCCGACCACTATAACGTGTTCCCCGCCCAGCTATGGCGCCTGCTCGGCGAACAAG
GGCTGCTCGGTCTGACCGTAGAAGACGCGTACGGCGGCAGCGGCATGGGCTATCTGGCGCACGTGGTGGCGATGGAAGAG
ATCTCCCGCGCTGGCGGTGCGATCGGGCTGTCGTATGGCGCGCATTCCAATCTGTGCCTGAACCAGCTGCGCAAGAACGC
CAGCCACGAGCAGAAGCAACGCTACCTGCCCAAGCTGTGCAGTGGCGAGCATGTGGGCGCGCTGGCGATGAGCGAAGCCG
GCTCCGGTTCGGACGTGGTGTCGATGAAGCTGCGCGCCGATGCGCGCGGCGACCGCTTTGTGCTCAACGGCAGCAAGATG
TGGATCACCAACGGCCCGGATGCCGACGTGCTGGTGGTGTACGCCAAGACCGACCCGGACGCCGGCGCGCGCGGCATCAC
CGCCTTTATCGTCGAGAAGGGCATGCCGGGCTTTTCCACGGCGCAGAAGCTCGACAAGCTGGGCATGCGCGGCTCCAACA
CCTGCGAGCTGGTGTTCACCGATTGCGAAGTACCGGCGGAAAACGTGCTGGGCACGCTCAACGGCGGCGTGCGTGTGCTG
ATGTCGGGGCTGGATTTCGAACGCGTGGTGCTGGCCGGCGGGCCGCTCGGGCTGATGGCCGCAGCAATGGACGTGGTGTT
GCCGTACGTGCACGAGCGCAAGCAGTTCGGCGAGCCGATCGGCACCTTCCAGTTGATGCAGGCCAAGCTGGCCGACATGT
ATGTGGGACTCAATGCCTGCCGCGCGTATGTGTATGCAGTGGCGCGCGCCTGCGATGCCGGGCGTACCACCCGCCAGGAC
GCAGCCGGCGCCATCCTGTATGCCGCCGAGAAGGCAACCTGGCTGACCGGCCAGGCCATCCAGGTGCTGGGTGGCAATGG
CTACATCAACGAGTACCCCACCGGACGCCTGTGGCGCGATGCCAAGTTGTACGAGATTGGCGCGGGCACCTCGGAAATCC
GGCGCATGCTGATCGGCCGCGAGTTGTTCGAACGCACCGCCTGA

Upstream 100 bases:

>100_bases
TTTAGTTCACTTTTTTGTTGCGGACCGCTAGTCTGGCCGCATCCGCCGCGCGGTCCGCCCGCTCCCACCCGGCACATCCC
GATCCCTGTGGAGTTGTTGC

Downstream 100 bases:

>100_bases
CGGAGCCACCATGAGCGTGATCGATAGCCAGCTGCAGGTCAGCGGCGAGAGTTTCCAACACAACGCCGCCGCGATGCGCG
CGGTGATCGACGACCTACGC

Product: acyl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHYNVFPAQLWRLLGEQGLLGLTVEDAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASHEQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Sequences:

>Translated_387_residues
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHYNVFPAQLWRLLGEQGLLGLTVEDAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASHEQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA
>Mature_387_residues
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHYNVFPAQLWRLLGEQGLLGLTVEDAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASHEQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=64.5333333333333, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=63.7837837837838, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=39.686684073107, Blast_Score=284, Evalue=8e-77,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=36.3874345549738, Blast_Score=264, Evalue=9e-71,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.0649350649351, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.0649350649351, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=32.7956989247312, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=36.9014084507042, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=32.4675324675325, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4557235, Length=388, Percent_Identity=35.5670103092784, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=35.5670103092784, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=31.8877551020408, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=32.8729281767956, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=24.4755244755245, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=24.4755244755245, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI38505218, Length=276, Percent_Identity=21.7391304347826, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=28.6089238845144, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=29.3193717277487, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=30.1158301158301, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081702, Length=272, Percent_Identity=24.6323529411765, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=62.8647214854111, Blast_Score=495, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=33.42175066313, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=34.3007915567282, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=35.0785340314136, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=34.2857142857143, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=33.1619537275064, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=38.2142857142857, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=30.952380952381, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=32.6760563380282, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.4014598540146, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.6320346320346, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=29.242819843342, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17505929, Length=368, Percent_Identity=30.7065217391304, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=29.0322580645161, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=32.280701754386, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.9623430962343, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=27.4021352313167, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=27.4021352313167, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=64.0419947506562, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=38.8888888888889, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=37.940379403794, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=35.5437665782493, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=35.9580052493438, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI281363737, Length=346, Percent_Identity=33.5260115606936, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=30.3108808290155, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41504; Mature: 41504

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHYNVFPAQLWRLLGEQGLLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEE
EDAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNASHEQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKMWITNGPDADVLVVYAKTDPD
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNAC
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGRTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHYNVFPAQLWRLLGEQGLLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEE
EDAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNASHEQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKMWITNGPDADVLVVYAKTDPD
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNAC
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGRTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]