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The map label for this gene is accD [H]

Identifier: 78045828

GI number: 78045828

Start: 317719

End: 319329

Strand: Reverse

Name: accD [H]

Synonym: XCV0272

Alternate gene names: 78045828

Gene position: 319329-317719 (Counterclockwise)

Preceding gene: 78045829

Following gene: 78045827

Centisome position: 6.17

GC content: 65.24

Gene sequence:

>1611_bases
ATGAGCGTGATCGATAGCCAGCTGCAGGTCAGCGGCGAGAGTTTCCAACACAACGCCGCCGCGATGCGCGCGGTGATCGA
CGACCTACGCCACACCCTCGCCCGGACCGCGCGTGGCGGCAGCGACGCCGCACGCGTCAAGCACACCGCACGCGGCAAGC
TGCTGGCGCGCGAGCGCATCGATGCCTTGCTGGATCCGGGCAGCCCATTGCTGGAGATCGCCCCCCTGGCCGCCCATGGC
ATGTACGACGACCAGGTCCCGTGCGCGGGCGTGGTGGCCGGCATTGGCCGCGTGTCCGGCGTGGAATGCGTGATCGTGGC
CAACGACGCCACCGTCAAGGGCGGCACCTATTACCCGATGACGGTGAAAAAGCACTTGCGTGCGCAGGAGATCGCGCAGC
AAAACCGGTTGCCGTGCATCTATCTGGTCGATTCCGGCGGCGCATTCCTGCCGTTGCAGGACGAAGTGTTTCCGGACCGC
GACCACTTCGGGCGCATCTTCTACAACCAGGCCAACCTGTCGGCCAACGGCATCCCGCAGATTGCCTGCGTAATGGGCTC
GTGCACCGCTGGCGGCGCCTATGTGCCGGCAATGAGCGATGAAACGGTGATCGTGCGCGAGCAAGGCACCATCTTCCTGG
GTGGCCCGCCGCTGGTGAAGGCCGCCACCGGCGAAGAAGTCAGTGCCGAAGACCTGGGCGGCGCCGATGTGCATACGCGC
ATTTCCGGCGTGGCCGATCACTTTGCCGACAACGATCTGCAGGCGCTGGCGCGCGTGCGCGCCATCATCGCGCAGCTCAA
CTGGCGCAAACCTGCCGCATCGCTGGCGCTGCAGGCACCGTTGCCGCCACGCTATGCCGCCGACGAACTATATGGCGTGA
TTCCTGCAGATACGCGCAAGCCGTTCGATGTGCGCGAAGTGATCGCGCGCATCGTCGACGATTCGCGCCTGGATGAATTC
AAACCGCGCTATGGCAGCACGCTGGTGACGGGGTTTGCGCACCTGCATGGCTACCCGGTCGGCATCATTGCCAACAACGG
CATTCTGTTTTCCGAGTCCGCGCTCAAGGGCGCGCACTTCATCGAGCTGTGCACGCAGCGCGGCATTCCGCTGGTCTTCC
TGCAGAACATCACCGGCTTCATGGTCGGGCGCAAATACGAACATGGCGGCATCGCCAAGGACGGCGCCAAGTTGGTGATG
GCGGTGGCCTGCGCCAAGGTGCCCAAGTTCACCGTGGTGATCGGCGGCTCGTTCGGTGCGGGCAACTACGGCATGTGCGG
ACGCGCGTATTCGCCGAACTTCTTGTGGATGTGGCCGAACGCGCGCATCGGCGTGATGGGTGGCGAGCAGGCGGCCAGCG
TGCTGGCCACGGTGCGTCGCGACGGCATCGAGGCCAAGGGCGGTGCATGGTCGGGCGAAGACGAGGATGCGTTCAAGGCG
CCGATCCGCGCGCAGTTCGAGCAGCAAGGCCATCCGTATTACGCTAGTGCTCGGCTCTGGGACGATGGCATCATCGATCC
GGCCGATACGCGCCGCGTGCTGGGCCTGGGATTGTCGGCGGCCTTGAACGCGCCGATCGAACCCACGCGCTTTGGCGTGT
TTCGCATGTGA

Upstream 100 bases:

>100_bases
CGCGATGCCAAGTTGTACGAGATTGGCGCGGGCACCTCGGAAATCCGGCGCATGCTGATCGGCCGCGAGTTGTTCGAACG
CACCGCCTGACGGAGCCACC

Downstream 100 bases:

>100_bases
GTGAGGGGGAGCATTGCAGCCGCGGTTCTGCGTGCTGCGGCACCCGATGCTGGTGTGCAGGCTGGGAGTGAGGTTGTGTA
TATGCGTGCCGGCAATCGTC

Product: acetyl-CoA carboxylase beta chain

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSVIDSQLQVSGESFQHNAAAMRAVIDDLRHTLARTARGGSDAARVKHTARGKLLARERIDALLDPGSPLLEIAPLAAHG
MYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDR
DHFGRIFYNQANLSANGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRKPFDVREVIARIVDDSRLDEF
KPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVM
AVACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGEDEDAFKA
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM

Sequences:

>Translated_536_residues
MSVIDSQLQVSGESFQHNAAAMRAVIDDLRHTLARTARGGSDAARVKHTARGKLLARERIDALLDPGSPLLEIAPLAAHG
MYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDR
DHFGRIFYNQANLSANGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRKPFDVREVIARIVDDSRLDEF
KPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVM
AVACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGEDEDAFKA
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM
>Mature_535_residues
SVIDSQLQVSGESFQHNAAAMRAVIDDLRHTLARTARGGSDAARVKHTARGKLLARERIDALLDPGSPLLEIAPLAAHGM
YDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRD
HFGRIFYNQANLSANGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTRI
SGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRKPFDVREVIARIVDDSRLDEFK
PRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMA
VACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGEDEDAFKAP
IRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=523, Percent_Identity=66.5391969407266, Blast_Score=714, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=532, Percent_Identity=32.7067669172932, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI295821216, Length=552, Percent_Identity=31.7028985507246, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=59.0909090909091, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17552936, Length=534, Percent_Identity=60.8614232209738, Blast_Score=686, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=485, Percent_Identity=35.8762886597938, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI25147359, Length=485, Percent_Identity=35.8762886597938, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=62.9764065335753, Blast_Score=716, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57391; Mature: 57260

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIDSQLQVSGESFQHNAAAMRAVIDDLRHTLARTARGGSDAARVKHTARGKLLARERI
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
DALLDPGSPLLEIAPLAAHGMYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPM
HHHHCCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRDHFGRIFYNQANLSANGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRK
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCHHHEEECCCCCCC
PFDVREVIARIVDDSRLDEFKPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHF
CCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEECHHHCCHHH
IELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMAVACAKVPKFTVVIGGSFGA
HHHHHHCCCCEEEECCCHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
GNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGEDEDAFKA
CCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHC
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM
CHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCEECC
>Mature Secondary Structure 
SVIDSQLQVSGESFQHNAAAMRAVIDDLRHTLARTARGGSDAARVKHTARGKLLARERI
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
DALLDPGSPLLEIAPLAAHGMYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPM
HHHHCCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRDHFGRIFYNQANLSANGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRK
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCHHHEEECCCCCCC
PFDVREVIARIVDDSRLDEFKPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHF
CCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEECHHHCCHHH
IELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMAVACAKVPKFTVVIGGSFGA
HHHHHHCCCCEEEECCCHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
GNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGEDEDAFKA
CCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHC
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM
CHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]