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The map label for this gene is napA [H]

Identifier: 78045817

GI number: 78045817

Start: 301751

End: 303013

Strand: Reverse

Name: napA [H]

Synonym: XCV0261

Alternate gene names: 78045817

Gene position: 303013-301751 (Counterclockwise)

Preceding gene: 78045818

Following gene: 78045816

Centisome position: 5.85

GC content: 66.27

Gene sequence:

>1263_bases
ATGAATCCGACCACGTTGTTGCTGGTGCAGTTGGCAGTGATCCTGGGCGCTGCGCGCCTGTGCGGTGCGTTGCTGCAACG
CATTGGGCAGCCGCCGGTCATCGGCGAAATGGCGGCCGGGTTGTTGCTCGGTCCGATCGCATTCGGTGCCTGGCTGCCCG
ACCTGCACATGGCGTTGTTCGCCGCCAGAAGCCTGCCGCCGCTGTCCGGCCTGGCCACGATGGGCGTGGTGCTTTTCATG
TTCGTGGTCGGTGTCGAATTGCGTGCGCCGGAAGGCACCAAAGCGCAAGTGCGCGCCTCGATCCTGGTGGGCGTATCCGG
CATCGTGTTGCCGCTGCTGCTCGGACTGGCTGCCGCGCCATGGCTGTTCCCGCGCTTCGCACCGCAAGGCGTCAGCTTCT
GGCCATTCGCGCTGTTCATTGCCGCGGCGATGTCGGTAACGGCATTTCCGGTGCTGGCGCGCATCCTCAAGGACCGCAAC
ATGACGCGGACGCCCGCCGGCCGCCTGGCGCTGGGCGCGGCCGTGATCGACGACGCCACGGTATGGATCTTCCTGGCGAT
CGTGCTGACCTTGACCGGCAACAACGCGCATGGCGGCGTGGCGTTCACGGCGATCGGTGCGTTGGTCTTGATCGCCGCCG
TGTTCGGTGTGCTCAAGCCTGCCTATGCGCGCGTGCTGCGCGCACGCGCGCATGACGGCCGGTATGCACCGAGCGCGCTG
GTATGGGTCTTGATCGGTCTGCTGGCGTGCGCCGCGCTGGCGGAGTGGATCGGGCTGCATGCGATCTTTGGCGCCTTCCT
GTTCGGCATTTGCCTGCCGCGCGATGACCGCCTGCTGGAACATCTGGCCGGGCGTATCGAGCCGCTGGCCATCACCCTAC
TGATGCCGGTGCTGTTTGCGGTTGCCGGTCAAGCCACCAGCCCTGGCGCATTCGCCGGCGCCGGCCTGAGCGGACTTGTG
CTGGTGATCGGGGTGGCGGTGGGCGGCAAGTTGCTCGGCTGCACGCTGGGTGCGCGCCTGAGCGGCCATCACTGGCGCGA
CAGTCTTACAGTGGGCTCGCTGATGAACGCACGCGGGCTGATGGAGTTGGTGGTGATCAAGATCGGCCTGGATAGCGGCG
TGATCGGGCCGGATCTGTTTACGCTGTTGTTCGGCATGACGCTGGTGACCACGGTCATGGCCTCGCCGATGGTGGCCTGG
TTCCAGCGCAAACGGCATGCAGCAGCCGATGCGCTGGCCGCAAGCAATTCACCTCACGGATGA

Upstream 100 bases:

>100_bases
CCGGCGTGCCGCGCATCGCCGTGCCGTCGGTTGGGGGAAACTTGCCGATGCCCTGCAGGACGCGCGGCTGAGCTGACTCA
ACCACTGGAATGCTCACGCG

Downstream 100 bases:

>100_bases
GGGCGCGATGGTGCTGCGGTGCCGCGTCAGGCCCGATACCGTGCATGCAACTGGGCTGCCGTGCAGCGCACGGCATTGAA
TCATGGCGCGCTCCACGTTG

Product: monovalent cation:proton antiporter-2 family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNPTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHMALFAARSLPPLSGLATMGVVLFM
FVVGVELRAPEGTKAQVRASILVGVSGIVLPLLLGLAAAPWLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRN
MTRTPAGRLALGAAVIDDATVWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAAVFGVLKPAYARVLRARAHDGRYAPSAL
VWVLIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFAVAGQATSPGAFAGAGLSGLV
LVIGVAVGGKLLGCTLGARLSGHHWRDSLTVGSLMNARGLMELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAW
FQRKRHAAADALAASNSPHG

Sequences:

>Translated_420_residues
MNPTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHMALFAARSLPPLSGLATMGVVLFM
FVVGVELRAPEGTKAQVRASILVGVSGIVLPLLLGLAAAPWLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRN
MTRTPAGRLALGAAVIDDATVWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAAVFGVLKPAYARVLRARAHDGRYAPSAL
VWVLIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFAVAGQATSPGAFAGAGLSGLV
LVIGVAVGGKLLGCTLGARLSGHHWRDSLTVGSLMNARGLMELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAW
FQRKRHAAADALAASNSPHG
>Mature_420_residues
MNPTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHMALFAARSLPPLSGLATMGVVLFM
FVVGVELRAPEGTKAQVRASILVGVSGIVLPLLLGLAAAPWLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRN
MTRTPAGRLALGAAVIDDATVWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAAVFGVLKPAYARVLRARAHDGRYAPSAL
VWVLIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFAVAGQATSPGAFAGAGLSGLV
LVIGVAVGGKLLGCTLGARLSGHHWRDSLTVGSLMNARGLMELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAW
FQRKRHAAADALAASNSPHG

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=408, Percent_Identity=32.5980392156863, Blast_Score=198, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43628; Mature: 43628

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHMALF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARSLPPLSGLATMGVVLFMFVVGVELRAPEGTKAQVRASILVGVSGIVLPLLLGLAAAP
HHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRNMTRTPAGRLALGAAVIDDAT
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAAVFGVLKPAYARVLRARAHDGRYAPSAL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VWVLIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VAGQATSPGAFAGAGLSGLVLVIGVAVGGKLLGCTLGARLSGHHWRDSLTVGSLMNARGL
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAWFQRKRHAAADALAASNSPHG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNPTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHMALF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARSLPPLSGLATMGVVLFMFVVGVELRAPEGTKAQVRASILVGVSGIVLPLLLGLAAAP
HHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRNMTRTPAGRLALGAAVIDDAT
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAAVFGVLKPAYARVLRARAHDGRYAPSAL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VWVLIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VAGQATSPGAFAGAGLSGLVLVIGVAVGGKLLGCTLGARLSGHHWRDSLTVGSLMNARGL
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAWFQRKRHAAADALAASNSPHG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]