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The map label for this gene is phhA [H]

Identifier: 78045713

GI number: 78045713

Start: 187253

End: 188143

Strand: Reverse

Name: phhA [H]

Synonym: XCV0157

Alternate gene names: 78045713

Gene position: 188143-187253 (Counterclockwise)

Preceding gene: 78045716

Following gene: 78045712

Centisome position: 3.63

GC content: 65.1

Gene sequence:

>891_bases
ATGAATACCGCCCCGCAACGCGTCGAAAACCAGCTCACCGACAAAGGCTATGTGCCGGTCTACACCACCGCGGTGGTGGA
GCAGCCGTGGGACAGCTACAGCGCCGACGACCACGCCACCTGGGGCACCTTGTATCGGCGCCAGCGCGAGCTGCTGGTGG
GCCGCGCCTGCGACGAGTTCCTGCAGGCGCAGGACGCGATGGGCATGGGCGAAACGCACATCCCGCGCTTCGATGCGCTC
AATCGCGTGCTGCAGGCGGCCACCGGCTGGACCCTGGTCGGCGTGCAGGGCCTGCTGCCGGAACTGGACTTTTTCGAACA
TCTGGCCAACAAACGCTTTCCGGTGACGTGGTGGATCCGCCGGCCCGATCAGATCGATTACATCGCCGAACCCGATCTGT
TCCATGACCTGTTCGGCCACGTGCCGTTGTTGATGAACCCGCTGTTTGCCGACTTCATGCAGGCCTATGGCCGCGGCGGG
GTCAAGGCGCACGGCATCGGCCCGGACGCGCAGCAGAACCTCACCCGGCTGTACTGGTACACGGTGGAATTCGGTCTGAT
CGACACGCCACAGGGCCTGCGCATCTACGGTGCCGGCATCGTGTCGTCCAAGGGCGAATCGCTGTATTCGCTGGACTCGC
CGGCACCCAACCGCATCGGGTTCGACCTGCAGCGCATCATGCGCACGCGCTACCGCATCGACAGCTTCCAGAAGACCTAT
TTCGTCATCGACAGCTTTGCGCAGCTGATGGAGGCCACCGCGCCGGACTTCACCCCGATCTATGCCGAGCTTGCCCAGCA
ACCGCAGGTGCCGGCGGGTGACGTGCTGCCGGGCGATCGGGTGATCCAACGCGGCAGCGGTGAGGGTTGGAGCCGCGACG
GCGACGTGTGA

Upstream 100 bases:

>100_bases
CGAATCTTGCGCCAATCCGCTTGCACCGCGCAAGATTCGCAATCCCGTTGCGCGCACATCCGGCCTAAGGTGACGGCTGA
TCACCGGGAAGAGCCGCTGC

Downstream 100 bases:

>100_bases
GGTCGCTGCCGAGGTCACGCCGACCAACCGCTGCGCGGCGGTGCGGCGCGGTCACGATGCCGCGATGTGACCTGCATCGA
CTCGACACCACCGCCGACGC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNTAPQRVENQLTDKGYVPVYTTAVVEQPWDSYSADDHATWGTLYRRQRELLVGRACDEFLQAQDAMGMGETHIPRFDAL
NRVLQAATGWTLVGVQGLLPELDFFEHLANKRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDAQQNLTRLYWYTVEFGLIDTPQGLRIYGAGIVSSKGESLYSLDSPAPNRIGFDLQRIMRTRYRIDSFQKTY
FVIDSFAQLMEATAPDFTPIYAELAQQPQVPAGDVLPGDRVIQRGSGEGWSRDGDV

Sequences:

>Translated_296_residues
MNTAPQRVENQLTDKGYVPVYTTAVVEQPWDSYSADDHATWGTLYRRQRELLVGRACDEFLQAQDAMGMGETHIPRFDAL
NRVLQAATGWTLVGVQGLLPELDFFEHLANKRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDAQQNLTRLYWYTVEFGLIDTPQGLRIYGAGIVSSKGESLYSLDSPAPNRIGFDLQRIMRTRYRIDSFQKTY
FVIDSFAQLMEATAPDFTPIYAELAQQPQVPAGDVLPGDRVIQRGSGEGWSRDGDV
>Mature_296_residues
MNTAPQRVENQLTDKGYVPVYTTAVVEQPWDSYSADDHATWGTLYRRQRELLVGRACDEFLQAQDAMGMGETHIPRFDAL
NRVLQAATGWTLVGVQGLLPELDFFEHLANKRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDAQQNLTRLYWYTVEFGLIDTPQGLRIYGAGIVSSKGESLYSLDSPAPNRIGFDLQRIMRTRYRIDSFQKTY
FVIDSFAQLMEATAPDFTPIYAELAQQPQVPAGDVLPGDRVIQRGSGEGWSRDGDV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=228, Percent_Identity=35.0877192982456, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI88900503, Length=244, Percent_Identity=35.655737704918, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI88900501, Length=244, Percent_Identity=35.655737704918, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI88900505, Length=244, Percent_Identity=35.655737704918, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI31795563, Length=227, Percent_Identity=34.3612334801762, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4759248, Length=227, Percent_Identity=33.920704845815, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=223, Percent_Identity=36.322869955157, Blast_Score=133, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI115533973, Length=237, Percent_Identity=32.0675105485232, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI115532103, Length=237, Percent_Identity=32.0675105485232, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71980736, Length=218, Percent_Identity=33.0275229357798, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71980731, Length=151, Percent_Identity=31.1258278145695, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI62472054, Length=229, Percent_Identity=36.2445414847162, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24660393, Length=229, Percent_Identity=36.2445414847162, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI17136776, Length=222, Percent_Identity=32.4324324324324, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136774, Length=222, Percent_Identity=32.4324324324324, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24654994, Length=247, Percent_Identity=32.7935222672065, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33452; Mature: 33452

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAPQRVENQLTDKGYVPVYTTAVVEQPWDSYSADDHATWGTLYRRQRELLVGRACDEF
CCCCHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQAQDAMGMGETHIPRFDALNRVLQAATGWTLVGVQGLLPELDFFEHLANKRFPVTWWIR
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHCCHHHHHHHHHCCCCCEEEEEE
RPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGGVKAHGIGPDAQQNLTRLYWY
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHEEEEE
TVEFGLIDTPQGLRIYGAGIVSSKGESLYSLDSPAPNRIGFDLQRIMRTRYRIDSFQKTY
EEEECEEECCCCCEEEECCEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FVIDSFAQLMEATAPDFTPIYAELAQQPQVPAGDVLPGDRVIQRGSGEGWSRDGDV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNTAPQRVENQLTDKGYVPVYTTAVVEQPWDSYSADDHATWGTLYRRQRELLVGRACDEF
CCCCHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQAQDAMGMGETHIPRFDALNRVLQAATGWTLVGVQGLLPELDFFEHLANKRFPVTWWIR
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHCCHHHHHHHHHCCCCCEEEEEE
RPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGGVKAHGIGPDAQQNLTRLYWY
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHEEEEE
TVEFGLIDTPQGLRIYGAGIVSSKGESLYSLDSPAPNRIGFDLQRIMRTRYRIDSFQKTY
EEEECEEECCCCCEEEECCEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FVIDSFAQLMEATAPDFTPIYAELAQQPQVPAGDVLPGDRVIQRGSGEGWSRDGDV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]