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The map label for this gene is 78045667

Identifier: 78045667

GI number: 78045667

Start: 128108

End: 129622

Strand: Reverse

Name: 78045667

Synonym: XCV0111

Alternate gene names: NA

Gene position: 129622-128108 (Counterclockwise)

Preceding gene: 78045668

Following gene: 78045666

Centisome position: 2.5

GC content: 65.87

Gene sequence:

>1515_bases
ATGCACCGTCGTCGCTTTCTGCAATCCCTGTTGGCCGCTGGCGGCAGCGCTGCGCTCGGCAGCTGGATGTTACGCAGTCT
GCCTGCACACGCCGCAGAAGCGGCAGCGTTTCATACACAGTTGCAGCGCACACCGTGGCTGCTGGGCTGGCGCAGCGTGA
CCAGCCCCACCTTCGGGCCGACCACCACGGCAGTGCAGGGCAAGCTTCCCGAAGGATTGGCAGGCAGCCTGTATCGCAAT
GGCCCTGCCTGGACCGAGCGCGCCGGGTTCCGCTACGAACACTGGTTCGATGGCGATGGCATGGTGCATCGCTGGCAGCT
GGGCGGCACCCAGGTGCAGCACGTCGGGCGCATGGTGGCGACGCATAAATTCACCCAGGAACAGCAGGCCGGACGTTTTC
TGTATCGCGCCGCTGGCACCTCCGTGCCCGACATGCAGCCGGTCCGCAATAACGACGACGTCAACACCGCCAATACCTCG
GTGGCGATGCTCAATGGCCGGTTGTTCGCATTATGGGAAGCGGGATCGGCGATCGAGCTGGATCCGGATGCGTTGCGCAC
GCTCGGCCCGGTGACCTGGCGCGACGATCTGGCTGCGATGCCGTTTTCCGCACACCCATTGATCGACCGCGACGGCAGCG
CATGGAACTTCGGCTCAATCAATGCGGCAGGCGCCAGCGGCGTGGTGCTCTGGCACCTGGGCGCAGATGCCACGTTGCGT
CACGTGCAGCTGCTGCACACCGACGCCCCCGGCTATATGCACAGCTTTGCCATGACAGATCGGCATTTGATTCTGGTCAT
GGCGCCGTACCGCCGGCTGGACGGCGAGGGCGCGTTCTTCGAAAGACTGCGCTTTACGCCCGAAGCGCCATCGCGGATTG
CGGTGGTGCCCAAGGATGCGTTGGACCAACCACGCTGGTTTGAAGCCGACTTTGCGGTGGCATACCACTTTGCCGACGCC
TATGCGCATCGCGACCGCATCGTGGTGCGCGCCATCGTGTACGACGATCCGGAGCAGGCGCGCTCGCCAATGCGTGCGGC
CATGCACGGCGACCCGGCGGCCGCACCATCACAGGTGCAACTGCGCAGCCTGCATCTGGACCTGAGCAACGGCCGCGCGC
ACTGGCAGCCGCATCCGGTGGATAATCTGGAATTGCCGTTGTACGACCGCCGCACCCCGACCACCACCGGCGCACGCCTG
TATGCGCCATGCATCGATGGGCCCGACAACTCGCCGTTCCTCAATGCCGTGGCCGGCTATGACCTGGAACGCGACCGCCG
CCAGGTGCATCGCTACGGGCCGGACGTGCTGGCCGAGGAACATGTGTTCGTCCCCAGGCCCGGCAGCGACCGCCCAGACG
ATGGCTGGTTGGTCGGCACCGTGCTGGACACCCGCCGCGGCCGCACCGGGCTGATGGTGCTGGACGCACGACATATCGAT
GCCGGGCCGGTGGCCCAGGCATGGCTTCCGTACGCGCTACCGCTAGGGTTTCACGGGCATTTTGCGCCCGCCTAG

Upstream 100 bases:

>100_bases
GCAAGCCTGGCTTCGACGAGATCGTCTTCGACCTGCCGGCCAGCGGGAAGCGCATCAGCGTGCAAATGCGCTGACACCGG
CACGCGATAGGAGCGCTGCC

Downstream 100 bases:

>100_bases
GCGGGCGCACAGCAACGGGCATGGCACTGCGTCGAGCCACATCCAGACCTAGAGTGCCGACTCGCTGCCCCGGTGCCGTG
CCGTCTTGGATGGATCGTCT

Product: putative lignostilbene-alpha,beta-dioxygenase

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MHRRRFLQSLLAAGGSAALGSWMLRSLPAHAAEAAAFHTQLQRTPWLLGWRSVTSPTFGPTTTAVQGKLPEGLAGSLYRN
GPAWTERAGFRYEHWFDGDGMVHRWQLGGTQVQHVGRMVATHKFTQEQQAGRFLYRAAGTSVPDMQPVRNNDDVNTANTS
VAMLNGRLFALWEAGSAIELDPDALRTLGPVTWRDDLAAMPFSAHPLIDRDGSAWNFGSINAAGASGVVLWHLGADATLR
HVQLLHTDAPGYMHSFAMTDRHLILVMAPYRRLDGEGAFFERLRFTPEAPSRIAVVPKDALDQPRWFEADFAVAYHFADA
YAHRDRIVVRAIVYDDPEQARSPMRAAMHGDPAAAPSQVQLRSLHLDLSNGRAHWQPHPVDNLELPLYDRRTPTTTGARL
YAPCIDGPDNSPFLNAVAGYDLERDRRQVHRYGPDVLAEEHVFVPRPGSDRPDDGWLVGTVLDTRRGRTGLMVLDARHID
AGPVAQAWLPYALPLGFHGHFAPA

Sequences:

>Translated_504_residues
MHRRRFLQSLLAAGGSAALGSWMLRSLPAHAAEAAAFHTQLQRTPWLLGWRSVTSPTFGPTTTAVQGKLPEGLAGSLYRN
GPAWTERAGFRYEHWFDGDGMVHRWQLGGTQVQHVGRMVATHKFTQEQQAGRFLYRAAGTSVPDMQPVRNNDDVNTANTS
VAMLNGRLFALWEAGSAIELDPDALRTLGPVTWRDDLAAMPFSAHPLIDRDGSAWNFGSINAAGASGVVLWHLGADATLR
HVQLLHTDAPGYMHSFAMTDRHLILVMAPYRRLDGEGAFFERLRFTPEAPSRIAVVPKDALDQPRWFEADFAVAYHFADA
YAHRDRIVVRAIVYDDPEQARSPMRAAMHGDPAAAPSQVQLRSLHLDLSNGRAHWQPHPVDNLELPLYDRRTPTTTGARL
YAPCIDGPDNSPFLNAVAGYDLERDRRQVHRYGPDVLAEEHVFVPRPGSDRPDDGWLVGTVLDTRRGRTGLMVLDARHID
AGPVAQAWLPYALPLGFHGHFAPA
>Mature_504_residues
MHRRRFLQSLLAAGGSAALGSWMLRSLPAHAAEAAAFHTQLQRTPWLLGWRSVTSPTFGPTTTAVQGKLPEGLAGSLYRN
GPAWTERAGFRYEHWFDGDGMVHRWQLGGTQVQHVGRMVATHKFTQEQQAGRFLYRAAGTSVPDMQPVRNNDDVNTANTS
VAMLNGRLFALWEAGSAIELDPDALRTLGPVTWRDDLAAMPFSAHPLIDRDGSAWNFGSINAAGASGVVLWHLGADATLR
HVQLLHTDAPGYMHSFAMTDRHLILVMAPYRRLDGEGAFFERLRFTPEAPSRIAVVPKDALDQPRWFEADFAVAYHFADA
YAHRDRIVVRAIVYDDPEQARSPMRAAMHGDPAAAPSQVQLRSLHLDLSNGRAHWQPHPVDNLELPLYDRRTPTTTGARL
YAPCIDGPDNSPFLNAVAGYDLERDRRQVHRYGPDVLAEEHVFVPRPGSDRPDDGWLVGTVLDTRRGRTGLMVLDARHID
AGPVAQAWLPYALPLGFHGHFAPA

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI74027270, Length=512, Percent_Identity=23.828125, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI82617628, Length=310, Percent_Identity=24.1935483870968, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI82617624, Length=310, Percent_Identity=24.1935483870968, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4506591, Length=237, Percent_Identity=24.0506329113924, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32564756, Length=514, Percent_Identity=24.124513618677, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71998242, Length=242, Percent_Identity=26.0330578512397, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646669, Length=319, Percent_Identity=20.6896551724138, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 55809; Mature: 55809

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRRRFLQSLLAAGGSAALGSWMLRSLPAHAAEAAAFHTQLQRTPWLLGWRSVTSPTFGP
CCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC
TTTAVQGKLPEGLAGSLYRNGPAWTERAGFRYEHWFDGDGMVHRWQLGGTQVQHVGRMVA
CCCEECCCCCCCCCCHHHCCCCCCHHHCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHH
THKFTQEQQAGRFLYRAAGTSVPDMQPVRNNDDVNTANTSVAMLNGRLFALWEAGSAIEL
HHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCCEEEE
DPDALRTLGPVTWRDDLAAMPFSAHPLIDRDGSAWNFGSINAAGASGVVLWHLGADATLR
CHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
HVQLLHTDAPGYMHSFAMTDRHLILVMAPYRRLDGEGAFFERLRFTPEAPSRIAVVPKDA
EEEEEECCCCCHHHHHHCCCCEEEEEEECHHHCCCCCHHHHHHCCCCCCCCEEEEECHHH
LDQPRWFEADFAVAYHFADAYAHRDRIVVRAIVYDDPEQARSPMRAAMHGDPAAAPSQVQ
CCCCCEECCCCEEEEHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCEE
LRSLHLDLSNGRAHWQPHPVDNLELPLYDRRTPTTTGARLYAPCIDGPDNSPFLNAVAGY
EEEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHCC
DLERDRRQVHRYGPDVLAEEHVFVPRPGSDRPDDGWLVGTVLDTRRGRTGLMVLDARHID
CCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCC
AGPVAQAWLPYALPLGFHGHFAPA
CCCHHHHHCCCEECCCCCCCCCCC
>Mature Secondary Structure
MHRRRFLQSLLAAGGSAALGSWMLRSLPAHAAEAAAFHTQLQRTPWLLGWRSVTSPTFGP
CCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC
TTTAVQGKLPEGLAGSLYRNGPAWTERAGFRYEHWFDGDGMVHRWQLGGTQVQHVGRMVA
CCCEECCCCCCCCCCHHHCCCCCCHHHCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHH
THKFTQEQQAGRFLYRAAGTSVPDMQPVRNNDDVNTANTSVAMLNGRLFALWEAGSAIEL
HHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCCEEEE
DPDALRTLGPVTWRDDLAAMPFSAHPLIDRDGSAWNFGSINAAGASGVVLWHLGADATLR
CHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
HVQLLHTDAPGYMHSFAMTDRHLILVMAPYRRLDGEGAFFERLRFTPEAPSRIAVVPKDA
EEEEEECCCCCHHHHHHCCCCEEEEEEECHHHCCCCCHHHHHHCCCCCCCCEEEEECHHH
LDQPRWFEADFAVAYHFADAYAHRDRIVVRAIVYDDPEQARSPMRAAMHGDPAAAPSQVQ
CCCCCEECCCCEEEEHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCEE
LRSLHLDLSNGRAHWQPHPVDNLELPLYDRRTPTTTGARLYAPCIDGPDNSPFLNAVAGY
EEEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHCC
DLERDRRQVHRYGPDVLAEEHVFVPRPGSDRPDDGWLVGTVLDTRRGRTGLMVLDARHID
CCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCC
AGPVAQAWLPYALPLGFHGHFAPA
CCCHHHHHCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]