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The map label for this gene is lldD [H]

Identifier: 78045666

GI number: 78045666

Start: 126802

End: 127968

Strand: Reverse

Name: lldD [H]

Synonym: XCV0110

Alternate gene names: 78045666

Gene position: 127968-126802 (Counterclockwise)

Preceding gene: 78045667

Following gene: 78045663

Centisome position: 2.47

GC content: 67.69

Gene sequence:

>1167_bases
ATGATCATTTCCGCCGCTTCCGACTACCGCGCCGCTGCGCAAGCACGCCTGCCGCCCTTCCTGTTCCATTACATCGATGG
CGGCGCGTATGCCGAACACACCTTGCGGCGCAATGTCTCGGACCTGGCAGATGTAGCGCTGCGCCAGCGGGTGCTGCGCA
ATATGTCGGATCTGCGCCTGAGCACCGAGCTGTTCGGCGAAACCCTGGCGATGCCGGTGGCATTGGCGCCGGTCGGCCTC
ACCGGCATGTATGCACGCCGCGGCGAAGTGCAGGCCGCGCGTGCGGCGGCCGCGCGCGGCATTCCCTTCACCCTGTCCAC
GGTGTCGGTGTGCCCGATCGAAGAAGTGGCGCCGGCCATCGAACGGCCGATGTGGTTCCAGCTCTATGTGCTCAAGGACC
GTGGCTTCATGCGCAATGCGCTGGAACGGGCCAAGGCCGCGGGCGTGACCACGCTGGTGTTCACCGTGGACATGCCCACG
CCGGGCGCGCGCTACCGCGATGCGCACTCGGGCATGAGCGGGCCCAATGCCTCGCTGCGGCGCATGCTGCAGGCAGTGAC
GCACCCCCGCTGGGCGTGGGACGTGGGCTTGCTCGGCAGGCCGCACGATCTGGGCAACATCTCCGCCTACCGCGGCAGCC
CCACCGGCCTGCAGGATTACATCGGCTGGCTGGGCGCCAACTTCGACCCGTCCATTGCCTGGAAAGACCTGGAATGGATC
CGCGAATTCTGGACCGGGCCGATGGTGATCAAGGGCATCCTGGACCCGGAGGACGCACGCGATGCGGTGCGCTTCGGCGC
CGACGGCATCGTGGTCTCCAACCACGGCGGCCGTCAGCTCGACGGCGTGCTGTCCAGCGCACGCGCGCTGCCGGCCATTG
CCGATGCGGTAAAGGGCGAACTGAAGATTCTGGCCGATTCGGGCATCCGCAGCGGGCTGGATGTGGTGCGCATGCTCGCG
CTCGGTGCCGATGCGGTATTGCTGGGCCGCGCGTTCGTCTACGCGCTGGCGGCCGCCGGGCAGGCCGGCGTGGAAAACCT
GCTGACCCTGATCGAAAAGGAAATGCGCGTGGCGATGACGCTGACCGGCACGCATTCCATCGCCGAGATCAGCGCCGACG
CGTTGAGCCGGGTGACGCGCGAGCGGGCAGAGACGATCTCGCCTTGA

Upstream 100 bases:

>100_bases
CATCCAGACCTAGAGTGCCGACTCGCTGCCCCGGTGCCGTGCCGTCTTGGATGGATCGTCTTACACTCGGCCGCTCCCCG
CCGCTGCCGTCCCGTCTTCG

Downstream 100 bases:

>100_bases
CGCCGCAAGACCGTCGCGCGTGATCGAGCGCTGTGAGCGGTTCGCCAGGCAGCTGACAGAAAGTGCCTCACCATTCGCGG
CCAAGCGCGCGCCGACAGGC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIISAASDYRAAAQARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGRPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIAEISADALSRVTRERAETISP

Sequences:

>Translated_388_residues
MIISAASDYRAAAQARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGRPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIAEISADALSRVTRERAETISP
>Mature_388_residues
MIISAASDYRAAAQARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGRPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIAEISADALSRVTRERAETISP

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=365, Percent_Identity=35.8904109589041, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=34.4086021505376, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=34.4086021505376, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1790033, Length=375, Percent_Identity=85.8666666666667, Blast_Score=668, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=370, Percent_Identity=34.0540540540541, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=283, Percent_Identity=33.2155477031802, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323587, Length=383, Percent_Identity=30.0261096605744, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=35.656836461126, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=35.656836461126, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=35.656836461126, Blast_Score=212, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41916; Mature: 41916

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISAASDYRAAAQARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRL
CEECCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
ERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLR
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAVTHPRWAWDVGLLGRPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEE
LTGTHSIAEISADALSRVTRERAETISP
EECCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIISAASDYRAAAQARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRL
CEECCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
ERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLR
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAVTHPRWAWDVGLLGRPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEE
LTGTHSIAEISADALSRVTRERAETISP
EECCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]