Click here to switch to the map view.

The map label for this gene is lon2 [H]

Identifier: 78044943

GI number: 78044943

Start: 282751

End: 284394

Strand: Direct

Name: lon2 [H]

Synonym: CHY_0329

Alternate gene names: 78044943

Gene position: 282751-284394 (Clockwise)

Preceding gene: 78042794

Following gene: 78044069

Centisome position: 11.77

GC content: 47.63

Gene sequence:

>1644_bases
ATGGACGGATTTAGCGGAATTTTAGCGGTGGGCCAAATTATTCTTTTAGCAGCAATTTTGGCCCTTCTCTTTTCTCAGGG
AAAAGCCCAGCAGGTAAATAAGAGTTATCTCGAGCGGGAAAGTGAAAAGGAGCTGGCTAAATTAAACCATTTACGCAGGA
TTTCTTTAACGGAACCATTAGCGGAAAAGACACGGCCGGAAAATTTTTCGGAAATCATCGGTCAGGAAGAAGGGATTGAA
GCTTTAAAAGCCGCATTATGCGGTCCCAATCCCCAGCATGTAATTTTATACGGACCACCGGGAGTAGGGAAAACAGCTGC
TGCCCGGCTGGTGTTAAAGGAAGCAATTAAAAGTCCCGCTTCTCCCTTTAAAGAAGGGGCTGCCTTTGTCGAGGTGGATG
CCACCTGTACCCGGTTTGACGAGCGGGGAATAGCCGATCCTCTTCTGGGCTCCGTTCACGACCCAATCTATCAGGGGGCA
GGGCCCTTAGGGATTGCCGGGATTCCCCAGCCTAAGCCGGGGGCTGTAACCAAAGCCCATGGGGGGATTTTATTTATTGA
TGAAATTGGGGAACTTCACCCGGTACAAATGAATAAGCTTTTAAAGGTTTTAGAAGACCGGAAGGTTTTTTTAGAAAGCG
CTTATTACTTTTCCGAAAATCCGGAAATTCCCCAGCATATTCATGAAATTTTTCAAAAAGGTCTGCCGGCGGATTTTCGT
TTAATTGGGGCAACCACCCGAAAGCCGGAAGAACTGCCACCGGCTTTAAGATCTCGGTGCGTGGAAATATTTTTTAAACC
CCTTGGCGATGAAGAAATTCGGGAAATTGCCCAAAATGCGGCAAAAAAGATAGGGATATCCCTTGGAAAGCATGCCCTGC
AAACAATTGTTAAATACGCCAACTCCGGGCGCGAAGCGGTTAATATCGTCCAGCTGGCGGCGGGGCTGGCGCTGGGGGAG
GGAAGAAAGAGGATTTTGGCAAGAGATGTGCTGTTCGTAGCCCGGGCGGGTAATTATCATCCAAAGCCCCAGATTGTTTT
ATCCGATGAGCCGGCGATAGGAAGGGCTCTGGGCCTTGCGGTGACTGGACCAAAAAGCGGTGCGGTTTTAGCCGTAGAAG
CATTGGCCGAACCTGCCGAAAACCTGCCCGGAAGTATCAACGTTTCCGGTATAATTGAAGAAGAAAAGTTTTCCCAAAGT
CATACCGAGCTTATTGCCCGCAGTAAAATTCGCGGGGCTCTTGATAATGTTTTTGCGGTTTTTCGAAGCCAAACGGGAAT
TAATCCCCAAAAATACGATATTTATTTTAACTTTCCGGCTCCCTGGCCGGTGGATGGTCCGTCGGCCGGGCTTGCCTTGC
TGGTAGCCCTTTATTCGGCAGTTTTCCGCTGTTTAATTCCGGCCAAAACCGCTTTTACCGGGGAAATTTCCCTTTTAGGT
GAAATTTGTCCCGTAGGCGGAATTCCCGATAAAATAGAAGCTGCAGTCAGGGCCGGAGTTAAAACTGTTTTTTTGCCCTG
GGGTAATTACCCCGAAGTAGAAGGAAATAAAAAAATAAACCTGGTTCCCGTAAAAAGTGTTGATGAAGCGTTAAATTATT
TATTTGCGGGAAAGGACCAATCCCTTCCTTCTTCCTTAGCTTGA

Upstream 100 bases:

>100_bases
TAACGGGAATTTTAATGTACCTGGTCTTTCGCAACGAAAATGAGTTAGATCTTTAAATAAACTGCCTCTTTCCGGTAATA
ATAGGAAAGAGGTGAGAAAA

Downstream 100 bases:

>100_bases
ACTTACTTTTTAGATTATTTTATGATAGAATAATGATACTCAAAAAGGGAGGTGGTTAGAAGTGGAAACAAGGGAATTAC
CGCTTTTGCCATTACGGGGC

Product: putative ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MDGFSGILAVGQIILLAAILALLFSQGKAQQVNKSYLERESEKELAKLNHLRRISLTEPLAEKTRPENFSEIIGQEEGIE
ALKAALCGPNPQHVILYGPPGVGKTAAARLVLKEAIKSPASPFKEGAAFVEVDATCTRFDERGIADPLLGSVHDPIYQGA
GPLGIAGIPQPKPGAVTKAHGGILFIDEIGELHPVQMNKLLKVLEDRKVFLESAYYFSENPEIPQHIHEIFQKGLPADFR
LIGATTRKPEELPPALRSRCVEIFFKPLGDEEIREIAQNAAKKIGISLGKHALQTIVKYANSGREAVNIVQLAAGLALGE
GRKRILARDVLFVARAGNYHPKPQIVLSDEPAIGRALGLAVTGPKSGAVLAVEALAEPAENLPGSINVSGIIEEEKFSQS
HTELIARSKIRGALDNVFAVFRSQTGINPQKYDIYFNFPAPWPVDGPSAGLALLVALYSAVFRCLIPAKTAFTGEISLLG
EICPVGGIPDKIEAAVRAGVKTVFLPWGNYPEVEGNKKINLVPVKSVDEALNYLFAGKDQSLPSSLA

Sequences:

>Translated_547_residues
MDGFSGILAVGQIILLAAILALLFSQGKAQQVNKSYLERESEKELAKLNHLRRISLTEPLAEKTRPENFSEIIGQEEGIE
ALKAALCGPNPQHVILYGPPGVGKTAAARLVLKEAIKSPASPFKEGAAFVEVDATCTRFDERGIADPLLGSVHDPIYQGA
GPLGIAGIPQPKPGAVTKAHGGILFIDEIGELHPVQMNKLLKVLEDRKVFLESAYYFSENPEIPQHIHEIFQKGLPADFR
LIGATTRKPEELPPALRSRCVEIFFKPLGDEEIREIAQNAAKKIGISLGKHALQTIVKYANSGREAVNIVQLAAGLALGE
GRKRILARDVLFVARAGNYHPKPQIVLSDEPAIGRALGLAVTGPKSGAVLAVEALAEPAENLPGSINVSGIIEEEKFSQS
HTELIARSKIRGALDNVFAVFRSQTGINPQKYDIYFNFPAPWPVDGPSAGLALLVALYSAVFRCLIPAKTAFTGEISLLG
EICPVGGIPDKIEAAVRAGVKTVFLPWGNYPEVEGNKKINLVPVKSVDEALNYLFAGKDQSLPSSLA
>Mature_547_residues
MDGFSGILAVGQIILLAAILALLFSQGKAQQVNKSYLERESEKELAKLNHLRRISLTEPLAEKTRPENFSEIIGQEEGIE
ALKAALCGPNPQHVILYGPPGVGKTAAARLVLKEAIKSPASPFKEGAAFVEVDATCTRFDERGIADPLLGSVHDPIYQGA
GPLGIAGIPQPKPGAVTKAHGGILFIDEIGELHPVQMNKLLKVLEDRKVFLESAYYFSENPEIPQHIHEIFQKGLPADFR
LIGATTRKPEELPPALRSRCVEIFFKPLGDEEIREIAQNAAKKIGISLGKHALQTIVKYANSGREAVNIVQLAAGLALGE
GRKRILARDVLFVARAGNYHPKPQIVLSDEPAIGRALGLAVTGPKSGAVLAVEALAEPAENLPGSINVSGIIEEEKFSQS
HTELIARSKIRGALDNVFAVFRSQTGINPQKYDIYFNFPAPWPVDGPSAGLALLVALYSAVFRCLIPAKTAFTGEISLLG
EICPVGGIPDKIEAAVRAGVKTVFLPWGNYPEVEGNKKINLVPVKSVDEALNYLFAGKDQSLPSSLA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=195, Percent_Identity=34.8717948717949, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786643, Length=472, Percent_Identity=24.364406779661, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 58783; Mature: 58783

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGFSGILAVGQIILLAAILALLFSQGKAQQVNKSYLERESEKELAKLNHLRRISLTEPL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AEKTRPENFSEIIGQEEGIEALKAALCGPNPQHVILYGPPGVGKTAAARLVLKEAIKSPA
HHHCCCCCHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
SPFKEGAAFVEVDATCTRFDERGIADPLLGSVHDPIYQGAGPLGIAGIPQPKPGAVTKAH
CHHHCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECC
GGILFIDEIGELHPVQMNKLLKVLEDRKVFLESAYYFSENPEIPQHIHEIFQKGLPADFR
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEE
LIGATTRKPEELPPALRSRCVEIFFKPLGDEEIREIAQNAAKKIGISLGKHALQTIVKYA
EEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSGREAVNIVQLAAGLALGEGRKRILARDVLFVARAGNYHPKPQIVLSDEPAIGRALGLA
HCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHEEEE
VTGPKSGAVLAVEALAEPAENLPGSINVSGIIEEEKFSQSHTELIARSKIRGALDNVFAV
EECCCCCCEEEHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRSQTGINPQKYDIYFNFPAPWPVDGPSAGLALLVALYSAVFRCLIPAKTAFTGEISLLG
HHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EICPVGGIPDKIEAAVRAGVKTVFLPWGNYPEVEGNKKINLVPVKSVDEALNYLFAGKDQ
HHCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCC
SLPSSLA
CCCCCCC
>Mature Secondary Structure
MDGFSGILAVGQIILLAAILALLFSQGKAQQVNKSYLERESEKELAKLNHLRRISLTEPL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AEKTRPENFSEIIGQEEGIEALKAALCGPNPQHVILYGPPGVGKTAAARLVLKEAIKSPA
HHHCCCCCHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
SPFKEGAAFVEVDATCTRFDERGIADPLLGSVHDPIYQGAGPLGIAGIPQPKPGAVTKAH
CHHHCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECC
GGILFIDEIGELHPVQMNKLLKVLEDRKVFLESAYYFSENPEIPQHIHEIFQKGLPADFR
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEE
LIGATTRKPEELPPALRSRCVEIFFKPLGDEEIREIAQNAAKKIGISLGKHALQTIVKYA
EEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSGREAVNIVQLAAGLALGEGRKRILARDVLFVARAGNYHPKPQIVLSDEPAIGRALGLA
HCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHEEEE
VTGPKSGAVLAVEALAEPAENLPGSINVSGIIEEEKFSQSHTELIARSKIRGALDNVFAV
EECCCCCCEEEHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRSQTGINPQKYDIYFNFPAPWPVDGPSAGLALLVALYSAVFRCLIPAKTAFTGEISLLG
HHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EICPVGGIPDKIEAAVRAGVKTVFLPWGNYPEVEGNKKINLVPVKSVDEALNYLFAGKDQ
HHCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCC
SLPSSLA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]