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The map label for this gene is uvrC

Identifier: 78044731

GI number: 78044731

Start: 232950

End: 234773

Strand: Direct

Name: uvrC

Synonym: CHY_0267

Alternate gene names: 78044731

Gene position: 232950-234773 (Clockwise)

Preceding gene: 78042837

Following gene: 78043283

Centisome position: 9.7

GC content: 41.34

Gene sequence:

>1824_bases
TTGACATTATGGGAAAAAGTCAAGAATTTACCCGACAGTCCCGGAGTTTATCTTTATAAAGACGAAAAGGGCGAGGTTAT
TTACGTTGGCAAGGCTAAAAACCTGAAAAATCGGGTGCGTTCGTACTTTCAACCTCCGGAAAAACTTTTGCCTAAAACCA
GGGTAATGATGGAAAAAGCAAGGGACATCGAAGTGATTATTACTTCTACGGAAGTAGAAGCTTTAATTTTAGAACAAAAC
CTCATAAAAAGATACCGGCCCCGGTATAATATTTTGCTGAAAGACGATAAGTCTTATCCTTACCTGAAAATTACCGGTGA
AGAGTTTCCCCGGCTTTTAATTACCCGCAGGGTAGTTAATGATGGTGGACGCTACTTTGGTCCGTACCCCGATGCGGGTG
CGTTAAACGAAACGTACAAGCTTTTACGGTCAATATTTAAATTTCGCACCTGTACCCCAACGATTTTTGCCCAGAAGAAG
CGTCCCTGCTTAAACTTTCATATAAAAAAATGTTCCGCCCCCTGTGCCGGGGAAATTAGCCGGGAAGAATATTTTAAAGA
AATCGAAATGGTGGTAGATTTTTTGGAAGGCAGGGGCGAAAATTTAATTAAAAAATTAAAAAAAGAAATGGCCATAGCTT
CTGATAATCTCGAATTTGAACGAGCGGCAAAATTAAGGGACCAGATCTTAGCTTTGGAAAAAATTTTGGCGAAACAAAAG
ATTTCCCGTGGCCAGAGAAATGCCGATGTAGTGGTTGTTGCTAACAGGGAAAACCTGGGGGTAGGATTGATTTTTGTTAT
TCGCCAGGGGAATTTATTAGGGCAGAAAGTTTATACCTTTACCGGCGAGATGGAAACCGGGGAGCTTTTAAATCAAGTTT
TAGTAACCCACTATGGAGAGGCCAAAGAAGTTCCTGTTGAAATTATCCTGTCAACCAGGGAAAATTTAGATGAAGAATTT
CTCAATTCCTGGTTTGAACTTAAATTTGGGAAAAAGCCCAAATTTACGGTCCCGAAGCGGGGAGAAAAATTTGAACTTTT
AAAAATGGCTTTAGAAAATGTAAACTTTACTCTGGATGAAAAAATTAAATTAAATGAAAAGAAACAATTGTTAAACGAAA
AGGCTTTAATGGACTTAAAAGAAGCCTTAAACCTTCCGGTGGTTCCAAGAAGAATTGAAGGATACGACATTTCCCACCTG
GCTGGAACGGGAACGGTAGCATCAATGGTGGTATTTATTGACGGTGAGCCGGTAAAGGGAAAATACCGGCGTTTTGCCAT
CCGCAGTGCGGCCAATGATGACTATACCGCGATGTTTGAAGCGGTTTTGCGGCGCTTTAAAAAGTACCTTGCTTTACAGG
AAGAGGGAGGAGCCGATGGCTCTTTTGAAGAGCTGCCGGATTTAGTGTTGATCGATGGCGGAAAAGGACAGTTGAACGCG
GCTATGGATGCTTTAAAAGAAACTAATCTTCTGGGGAAGTTTACGGTAATTGCCCTTGCCAAGGAGCAGGAGGAAATTTT
TCTTCCCGGGAAAAAGGACTCTCTTTTATTGACACAGGACCGGGAAGGTTTAAAATTGTTACAAAGGGTACGAGATGAGG
CCCACCGTTTTGCCAGAGGTTACCAGGAAAAAAAGCGGGTTAAAACCCTTGCTTCTCTTTTAGAGCAAGTAGAAGGAATT
GGTCCCAAAAGGCGAAAACAACTTCTTAATAAATTTGGCAGCATTAAAAACCTTAGAGAAGCAACGGTTGAAGAGATTAC
AGCGGTTCCCGGAATTACCCGGGAAATAGCAGAAAGATTAAAAGAGCTTTTGGAAATGGAGTGA

Upstream 100 bases:

>100_bases
AAGTCAGGCAATTTTTAAAGAATTTTTCGGAAGGAGTCCGAGGTTCTGTAGATGTGAAAGGCTGGTTTTTAAAGCGAATG
GAGCAAGTGAGGGATTAAAG

Downstream 100 bases:

>100_bases
TTTTTTGCGGTACCGATTATTAGCTGTGGACCTGGATGATACTTTTTTAAACAAGGAATTGCAGGTTTCGCCACGGGTAC
AACAAGCGGTGATAGAGGCT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MTLWEKVKNLPDSPGVYLYKDEKGEVIYVGKAKNLKNRVRSYFQPPEKLLPKTRVMMEKARDIEVIITSTEVEALILEQN
LIKRYRPRYNILLKDDKSYPYLKITGEEFPRLLITRRVVNDGGRYFGPYPDAGALNETYKLLRSIFKFRTCTPTIFAQKK
RPCLNFHIKKCSAPCAGEISREEYFKEIEMVVDFLEGRGENLIKKLKKEMAIASDNLEFERAAKLRDQILALEKILAKQK
ISRGQRNADVVVVANRENLGVGLIFVIRQGNLLGQKVYTFTGEMETGELLNQVLVTHYGEAKEVPVEIILSTRENLDEEF
LNSWFELKFGKKPKFTVPKRGEKFELLKMALENVNFTLDEKIKLNEKKQLLNEKALMDLKEALNLPVVPRRIEGYDISHL
AGTGTVASMVVFIDGEPVKGKYRRFAIRSAANDDYTAMFEAVLRRFKKYLALQEEGGADGSFEELPDLVLIDGGKGQLNA
AMDALKETNLLGKFTVIALAKEQEEIFLPGKKDSLLLTQDREGLKLLQRVRDEAHRFARGYQEKKRVKTLASLLEQVEGI
GPKRRKQLLNKFGSIKNLREATVEEITAVPGITREIAERLKELLEME

Sequences:

>Translated_607_residues
MTLWEKVKNLPDSPGVYLYKDEKGEVIYVGKAKNLKNRVRSYFQPPEKLLPKTRVMMEKARDIEVIITSTEVEALILEQN
LIKRYRPRYNILLKDDKSYPYLKITGEEFPRLLITRRVVNDGGRYFGPYPDAGALNETYKLLRSIFKFRTCTPTIFAQKK
RPCLNFHIKKCSAPCAGEISREEYFKEIEMVVDFLEGRGENLIKKLKKEMAIASDNLEFERAAKLRDQILALEKILAKQK
ISRGQRNADVVVVANRENLGVGLIFVIRQGNLLGQKVYTFTGEMETGELLNQVLVTHYGEAKEVPVEIILSTRENLDEEF
LNSWFELKFGKKPKFTVPKRGEKFELLKMALENVNFTLDEKIKLNEKKQLLNEKALMDLKEALNLPVVPRRIEGYDISHL
AGTGTVASMVVFIDGEPVKGKYRRFAIRSAANDDYTAMFEAVLRRFKKYLALQEEGGADGSFEELPDLVLIDGGKGQLNA
AMDALKETNLLGKFTVIALAKEQEEIFLPGKKDSLLLTQDREGLKLLQRVRDEAHRFARGYQEKKRVKTLASLLEQVEGI
GPKRRKQLLNKFGSIKNLREATVEEITAVPGITREIAERLKELLEME
>Mature_606_residues
TLWEKVKNLPDSPGVYLYKDEKGEVIYVGKAKNLKNRVRSYFQPPEKLLPKTRVMMEKARDIEVIITSTEVEALILEQNL
IKRYRPRYNILLKDDKSYPYLKITGEEFPRLLITRRVVNDGGRYFGPYPDAGALNETYKLLRSIFKFRTCTPTIFAQKKR
PCLNFHIKKCSAPCAGEISREEYFKEIEMVVDFLEGRGENLIKKLKKEMAIASDNLEFERAAKLRDQILALEKILAKQKI
SRGQRNADVVVVANRENLGVGLIFVIRQGNLLGQKVYTFTGEMETGELLNQVLVTHYGEAKEVPVEIILSTRENLDEEFL
NSWFELKFGKKPKFTVPKRGEKFELLKMALENVNFTLDEKIKLNEKKQLLNEKALMDLKEALNLPVVPRRIEGYDISHLA
GTGTVASMVVFIDGEPVKGKYRRFAIRSAANDDYTAMFEAVLRRFKKYLALQEEGGADGSFEELPDLVLIDGGKGQLNAA
MDALKETNLLGKFTVIALAKEQEEIFLPGKKDSLLLTQDREGLKLLQRVRDEAHRFARGYQEKKRVKTLASLLEQVEGIG
PKRRKQLLNKFGSIKNLREATVEEITAVPGITREIAERLKELLEME

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=613, Percent_Identity=38.3360522022839, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1788037, Length=183, Percent_Identity=25.6830601092896, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CARHZ (Q3AFE5)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359139.1
- ProteinModelPortal:   Q3AFE5
- STRING:   Q3AFE5
- GeneID:   3727854
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0267
- NMPDR:   fig|246194.3.peg.278
- TIGR:   CHY_0267
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- BioCyc:   CHYD246194:CHY_0267-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69489; Mature: 69358

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLWEKVKNLPDSPGVYLYKDEKGEVIYVGKAKNLKNRVRSYFQPPEKLLPKTRVMMEKA
CCHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCHHHHCCHHHHHHHHC
RDIEVIITSTEVEALILEQNLIKRYRPRYNILLKDDKSYPYLKITGEEFPRLLITRRVVN
CCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHH
DGGRYFGPYPDAGALNETYKLLRSIFKFRTCTPTIFAQKKRPCLNFHIKKCSAPCAGEIS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHEEEHHCCCCCCCCCH
REEYFKEIEMVVDFLEGRGENLIKKLKKEMAIASDNLEFERAAKLRDQILALEKILAKQK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ISRGQRNADVVVVANRENLGVGLIFVIRQGNLLGQKVYTFTGEMETGELLNQVLVTHYGE
HHCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC
AKEVPVEIILSTRENLDEEFLNSWFELKFGKKPKFTVPKRGEKFELLKMALENVNFTLDE
CCCCCHHEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
KIKLNEKKQLLNEKALMDLKEALNLPVVPRRIEGYDISHLAGTGTVASMVVFIDGEPVKG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCCCC
KYRRFAIRSAANDDYTAMFEAVLRRFKKYLALQEEGGADGSFEELPDLVLIDGGKGQLNA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCHHH
AMDALKETNLLGKFTVIALAKEQEEIFLPGKKDSLLLTQDREGLKLLQRVRDEAHRFARG
HHHHHHHHCCHHHEEEEEEECCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
YQEKKRVKTLASLLEQVEGIGPKRRKQLLNKFGSIKNLREATVEEITAVPGITREIAERL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHH
KELLEME
HHHHCCC
>Mature Secondary Structure 
TLWEKVKNLPDSPGVYLYKDEKGEVIYVGKAKNLKNRVRSYFQPPEKLLPKTRVMMEKA
CHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCHHHHCCHHHHHHHHC
RDIEVIITSTEVEALILEQNLIKRYRPRYNILLKDDKSYPYLKITGEEFPRLLITRRVVN
CCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHH
DGGRYFGPYPDAGALNETYKLLRSIFKFRTCTPTIFAQKKRPCLNFHIKKCSAPCAGEIS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHEEEHHCCCCCCCCCH
REEYFKEIEMVVDFLEGRGENLIKKLKKEMAIASDNLEFERAAKLRDQILALEKILAKQK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ISRGQRNADVVVVANRENLGVGLIFVIRQGNLLGQKVYTFTGEMETGELLNQVLVTHYGE
HHCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC
AKEVPVEIILSTRENLDEEFLNSWFELKFGKKPKFTVPKRGEKFELLKMALENVNFTLDE
CCCCCHHEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
KIKLNEKKQLLNEKALMDLKEALNLPVVPRRIEGYDISHLAGTGTVASMVVFIDGEPVKG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCCCC
KYRRFAIRSAANDDYTAMFEAVLRRFKKYLALQEEGGADGSFEELPDLVLIDGGKGQLNA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCHHH
AMDALKETNLLGKFTVIALAKEQEEIFLPGKKDSLLLTQDREGLKLLQRVRDEAHRFARG
HHHHHHHHCCHHHEEEEEEECCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
YQEKKRVKTLASLLEQVEGIGPKRRKQLLNKFGSIKNLREATVEEITAVPGITREIAERL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHH
KELLEME
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA