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The map label for this gene is groEL

Identifier: 78044694

GI number: 78044694

Start: 714805

End: 716427

Strand: Direct

Name: groEL

Synonym: CHY_0807

Alternate gene names: 78044694

Gene position: 714805-716427 (Clockwise)

Preceding gene: 78044510

Following gene: 78043721

Centisome position: 29.76

GC content: 47.5

Gene sequence:

>1623_bases
ATGGCTGGCAAACAAATATTATTTAGAGAAGATGCCCGGAGAGCTTTAGAAAGAGGCGTAAACGCTCTGGCAGATGCGGT
AAAGGTTACTCTTGGTCCGAAAGGCCGTAACGTTGTTTTAGAAAAGAAATTTGGTTCACCGCAAATTATTAACGACGGTG
TTTCCATTGCTCGGGAAATTGAACTTGCTGACCCTGTAGAAAACATGGGAGCGCAGCTTGTAAAAGAAGTTGCTACCAAA
ACCAACGATGTAGCCGGTGACGGTACTACCACCGCTACCGTTTTGGCTCAGGCTATCATTCGGGAAGGCTTAAAGAACGT
TACTGCCGGTGCCAACCCGATGATTTTACGGAAAGGTATTGAAAAAGCTGTTGCCAAAGCGGTAGAAGAAATTAAGGCTA
TTGCCAAGCCGGTAGAAACTTCCGAAGCTATCGCCCAGGTTGCTGCAATTTCTGCTAACGACGAGGAAATCGGTAAGCTA
ATTGCTGAAGCAATGGAAAAAGTGGGTAAAGACGGGGTTATCACCGTAGAAGAGTCCCAGGGTCTTGGCACTACCTTAGA
AGTAGTTGAAGGTATGAGCTTTGACCGGGGTTACATTTCTCCTTACATGATTACCGACCCCGATAAGATGGAAGCTATTT
TAAACGATCCTTACATCCTCATCACCGATAAGAAGATTTCCGCGATTGCTGACTTACTGCCGATTTTAGAAAAAGTTGTG
CAAACCGGTAAGCCCCTTTTAATCATTGCTGAAGATGTCGAAGGGGAAGCTCTCGCTACCCTGGTTGTGAACAAACTGCG
CGGTACCTTGACCTGTGTCGCTGTAAAAGCTCCCGGCTTTGGTGACCGGAGAAAGGCTATGCTTGAAGATATCGCCATCC
TCACCAACGGCCAGGTGGTAAGCGAAGAGCTTGGCTTTAAGCTCGAAAATGCTACCCTTTCGATGCTCGGTCGGGCTAAG
CAAGTCCGGGTTAAGAAAGAAGAAACCATCATTGTTGGTGGTCAAGGTTCTCCGGAAGCTATTGAAAAGCGGATTGCTCA
AATCAAGAAGCAAATCGAAGAAACCACTTCCGATTTTGACCGGGAAAAATTACAGGAGCGTCTGGCTAAGCTTGCCGGTG
GCGTAGCGGTAATCCAGGTAGGTGCTGCTACCGAAACCGAAATGAAAGAAAAGAAACTCCGCATTGAAGACGCTTTGAAC
GCTACCCGGGCAGCGGTGGAAGAAGGTATTGTAGCTGGTGGTGGCACAACCTACATCCACATCATTAAGGCTTTGGAAGA
GCTTGAAAAGACCGCTACCGGCGATGAAAGAACCGGTATCGCCATTGTCCGGAAAGCTTTAGAAGAACCCTTAAAGCAAA
TTGCTATTAACGCTGGCTTAGAGGGTTCGGTCATCGTTGAAAAGGTTAAGACCTTACCGGTAGGCCATGGCTTCAACGCT
CTAACCGAAGAATATGTTGACATGATAGCTGCTGGTATTGTTGACCCGGCTAAGGTCACCCGGAGTGCTTTACAAAACGC
TGCCTCCGTTGCTGCTATGCTCCTCACCACGGAAGCTTTGGTGGCTGAAAAGCCGGAAAAAGAAAAGAAAGGCCCTGACA
TGCCCAACATGGACATGATGTAA

Upstream 100 bases:

>100_bases
GTACCGAAGTGAAAATTGATGGTGAAGAGTATTTAATCTTACGGGAAAGCGATATCCTCGGGATTTTAGAATAAAAAACA
CAAAAAAAGGAGGGGTATAA

Downstream 100 bases:

>100_bases
AACCTTATAACCGGAGCGTAAAGGCTCCGGTTTTTTTATGGATTAAAAACATAATAGTTGACAGGATTAGTAGGAATTAA
TATAATGGGTTTAGAAGGAC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAGKQILFREDARRALERGVNALADAVKVTLGPKGRNVVLEKKFGSPQIINDGVSIAREIELADPVENMGAQLVKEVATK
TNDVAGDGTTTATVLAQAIIREGLKNVTAGANPMILRKGIEKAVAKAVEEIKAIAKPVETSEAIAQVAAISANDEEIGKL
IAEAMEKVGKDGVITVEESQGLGTTLEVVEGMSFDRGYISPYMITDPDKMEAILNDPYILITDKKISAIADLLPILEKVV
QTGKPLLIIAEDVEGEALATLVVNKLRGTLTCVAVKAPGFGDRRKAMLEDIAILTNGQVVSEELGFKLENATLSMLGRAK
QVRVKKEETIIVGGQGSPEAIEKRIAQIKKQIEETTSDFDREKLQERLAKLAGGVAVIQVGAATETEMKEKKLRIEDALN
ATRAAVEEGIVAGGGTTYIHIIKALEELEKTATGDERTGIAIVRKALEEPLKQIAINAGLEGSVIVEKVKTLPVGHGFNA
LTEEYVDMIAAGIVDPAKVTRSALQNAASVAAMLLTTEALVAEKPEKEKKGPDMPNMDMM

Sequences:

>Translated_540_residues
MAGKQILFREDARRALERGVNALADAVKVTLGPKGRNVVLEKKFGSPQIINDGVSIAREIELADPVENMGAQLVKEVATK
TNDVAGDGTTTATVLAQAIIREGLKNVTAGANPMILRKGIEKAVAKAVEEIKAIAKPVETSEAIAQVAAISANDEEIGKL
IAEAMEKVGKDGVITVEESQGLGTTLEVVEGMSFDRGYISPYMITDPDKMEAILNDPYILITDKKISAIADLLPILEKVV
QTGKPLLIIAEDVEGEALATLVVNKLRGTLTCVAVKAPGFGDRRKAMLEDIAILTNGQVVSEELGFKLENATLSMLGRAK
QVRVKKEETIIVGGQGSPEAIEKRIAQIKKQIEETTSDFDREKLQERLAKLAGGVAVIQVGAATETEMKEKKLRIEDALN
ATRAAVEEGIVAGGGTTYIHIIKALEELEKTATGDERTGIAIVRKALEEPLKQIAINAGLEGSVIVEKVKTLPVGHGFNA
LTEEYVDMIAAGIVDPAKVTRSALQNAASVAAMLLTTEALVAEKPEKEKKGPDMPNMDMM
>Mature_539_residues
AGKQILFREDARRALERGVNALADAVKVTLGPKGRNVVLEKKFGSPQIINDGVSIAREIELADPVENMGAQLVKEVATKT
NDVAGDGTTTATVLAQAIIREGLKNVTAGANPMILRKGIEKAVAKAVEEIKAIAKPVETSEAIAQVAAISANDEEIGKLI
AEAMEKVGKDGVITVEESQGLGTTLEVVEGMSFDRGYISPYMITDPDKMEAILNDPYILITDKKISAIADLLPILEKVVQ
TGKPLLIIAEDVEGEALATLVVNKLRGTLTCVAVKAPGFGDRRKAMLEDIAILTNGQVVSEELGFKLENATLSMLGRAKQ
VRVKKEETIIVGGQGSPEAIEKRIAQIKKQIEETTSDFDREKLQERLAKLAGGVAVIQVGAATETEMKEKKLRIEDALNA
TRAAVEEGIVAGGGTTYIHIIKALEELEKTATGDERTGIAIVRKALEEPLKQIAINAGLEGSVIVEKVKTLPVGHGFNAL
TEEYVDMIAAGIVDPAKVTRSALQNAASVAAMLLTTEALVAEKPEKEKKGPDMPNMDMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=50.5681818181818, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=50.5681818181818, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI5453607, Length=546, Percent_Identity=23.2600732600733, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI38455427, Length=492, Percent_Identity=23.1707317073171, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI58331173, Length=216, Percent_Identity=25.462962962963, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=63.8941398865785, Blast_Score=646, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=49.0530303030303, Blast_Score=487, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=48.8151658767773, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI25144674, Length=171, Percent_Identity=27.4853801169591, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=54.0952380952381, Blast_Score=527, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322350, Length=547, Percent_Identity=22.8519195612431, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322446, Length=171, Percent_Identity=32.1637426900585, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=50.2846299810247, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=50.2846299810247, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=48.5768500948767, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=48.5768500948767, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=48.5768500948767, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=43.1558935361217, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=36.4839319470699, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=36.4839319470699, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI24645179, Length=526, Percent_Identity=23.1939163498099, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583944, Length=152, Percent_Identity=28.2894736842105, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_CARHZ (Q3ADX3)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359661.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q3ADX3
- SMR:   Q3ADX3
- STRING:   Q3ADX3
- GeneID:   3727816
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0807
- NMPDR:   fig|246194.3.peg.994
- TIGR:   CHY_0807
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   MAAKEIL
- ProtClustDB:   PRK00013
- BioCyc:   CHYD246194:CHY_0807-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57606; Mature: 57474

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGKQILFREDARRALERGVNALADAVKVTLGPKGRNVVLEKKFGSPQIINDGVSIAREI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCEECCCHHHHHHH
ELADPVENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREGLKNVTAGANPMILRKGI
HHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EKAVAKAVEEIKAIAKPVETSEAIAQVAAISANDEEIGKLIAEAMEKVGKDGVITVEESQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
GLGTTLEVVEGMSFDRGYISPYMITDPDKMEAILNDPYILITDKKISAIADLLPILEKVV
CCCHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
QTGKPLLIIAEDVEGEALATLVVNKLRGTLTCVAVKAPGFGDRRKAMLEDIAILTNGQVV
HCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEE
SEELGFKLENATLSMLGRAKQVRVKKEETIIVGGQGSPEAIEKRIAQIKKQIEETTSDFD
HHHHCCEECHHHHHHHCCHHHHEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
REKLQERLAKLAGGVAVIQVGAATETEMKEKKLRIEDALNATRAAVEEGIVAGGGTTYIH
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IIKALEELEKTATGDERTGIAIVRKALEEPLKQIAINAGLEGSVIVEKVKTLPVGHGFNA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHH
LTEEYVDMIAAGIVDPAKVTRSALQNAASVAAMLLTTEALVAEKPEKEKKGPDMPNMDMM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
AGKQILFREDARRALERGVNALADAVKVTLGPKGRNVVLEKKFGSPQIINDGVSIAREI
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCEECCCHHHHHHH
ELADPVENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREGLKNVTAGANPMILRKGI
HHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EKAVAKAVEEIKAIAKPVETSEAIAQVAAISANDEEIGKLIAEAMEKVGKDGVITVEESQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
GLGTTLEVVEGMSFDRGYISPYMITDPDKMEAILNDPYILITDKKISAIADLLPILEKVV
CCCHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
QTGKPLLIIAEDVEGEALATLVVNKLRGTLTCVAVKAPGFGDRRKAMLEDIAILTNGQVV
HCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEE
SEELGFKLENATLSMLGRAKQVRVKKEETIIVGGQGSPEAIEKRIAQIKKQIEETTSDFD
HHHHCCEECHHHHHHHCCHHHHEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
REKLQERLAKLAGGVAVIQVGAATETEMKEKKLRIEDALNATRAAVEEGIVAGGGTTYIH
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IIKALEELEKTATGDERTGIAIVRKALEEPLKQIAINAGLEGSVIVEKVKTLPVGHGFNA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHH
LTEEYVDMIAAGIVDPAKVTRSALQNAASVAAMLLTTEALVAEKPEKEKKGPDMPNMDMM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA