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The map label for this gene is atoB [H]

Identifier: 78044570

GI number: 78044570

Start: 1213541

End: 1214722

Strand: Direct

Name: atoB [H]

Synonym: CHY_1355

Alternate gene names: 78044570

Gene position: 1213541-1214722 (Clockwise)

Preceding gene: 78044790

Following gene: 78043620

Centisome position: 50.53

GC content: 45.35

Gene sequence:

>1182_bases
ATGGAAGAAGTTGTAATAGTTAGTGCCGTTAGAACTCCCATTGGCAGTTTTTTGGGTAGCCTTGCCCAAACTCCGGCAGT
GGATTTGGGAGCGCTTGTTATTAAAGAAAGTCTAAACCGCATTAACCTTGCGCCCCGGTTTGTCGATGAGGTTATCATGG
GAAACGTTTTGCAGGCAGGATTAGGCCAGAACCCAGCCCGGCAGGCAGCTATAAAAGCAGGAATACCCCAGGAAGTACCT
GCTTTTACAGTAAACAAAGTTTGCGGTTCAGGATTAAAATCCGTCGGACTGGCTTATCAGGCAATAGCAACAGGTGATGC
CGATATCGTTGTCGCCGGGGGAATGGAAAACATGTCTTTAGCACCTTACGTCTTGCCCAAAGCCAGGACAGGTTACCGCA
TGGGGCATGATACCCTGATAGATTCCATGATTAAAGATGGCTTATGGTGTGCTTTTACCGATGTGCATATGGGTATTACC
GCGGAAAATATAGCCGAAAAATACAATATAACCCGCGAAGAACAGGATAAATTTGCCCTGCAAAGTCAGGAAAGAGCTAT
AAAAGCAATTGATGAAGGAAAGTTTAAAGAAGAAATCGTTCCCGTAATCATCCCCCAGAAAAAAGGAGAACCCCTGGTAT
TTTCCACCGATGAATTTCCCAAACGCGGTACATCCCTGGAAAAACTTGCCGCTCTAAAACCGGCCTTCAAAAAAGATGGT
ACCGTAACTGCCGGAAATGCCTCGGGAATTAACGATGGAGCTGCTGCGGTTGTAGTTATGTCAGCAAAAAAAGCTCAAGA
GTTAAATATTAAACCCTTGGCTGTTATCCGCGGTTATGCAGCTGCGGGAGTAGATCCTGCCTATATGGGTTTAGGCCCAA
TACCTGCCACCCGCAAAGCCCTTAAAAAAGCCAATTTAACCGTTTCGGACTTGGGGCTTATTGAAGCAAACGAAGCTTTT
GCCGCCCAGGCTTTAGCGGTAATTAAAGAGCTCGAATTAAATCCGGAAATAACTAATGTCAACGGTGGTGCCATAGCGTT
AGGTCACCCCATAGGAGCCTCGGGAGCTCGAATATTGGTAACCTTATTACATGAGATGCAAAAACGTAATACAAAATACG
GTTTAGCAACCTTGTGTATCGGTGGCGGCCAAGGATTTGCTTTAGTAGTTGAAAAAGTTTAA

Upstream 100 bases:

>100_bases
AAGAGGAGATTGGCTTTAATTATACTTCTTGGGGTGTAGACCAACAACTACACCCCCATTTTTCAACTATGAAAAATGTT
TTAGAGGGGGAGAATGGTAA

Downstream 100 bases:

>100_bases
AAGCCGGAAATTCCGGCTTTTTTTCTTTGGTTTAAAGTGGTAAAATTTTGGGTAAAGAAAAAGGAGGTTATAACTATTTT
TTTAGTTAGCGCTTGTTTAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MEEVVIVSAVRTPIGSFLGSLAQTPAVDLGALVIKESLNRINLAPRFVDEVIMGNVLQAGLGQNPARQAAIKAGIPQEVP
AFTVNKVCGSGLKSVGLAYQAIATGDADIVVAGGMENMSLAPYVLPKARTGYRMGHDTLIDSMIKDGLWCAFTDVHMGIT
AENIAEKYNITREEQDKFALQSQERAIKAIDEGKFKEEIVPVIIPQKKGEPLVFSTDEFPKRGTSLEKLAALKPAFKKDG
TVTAGNASGINDGAAAVVVMSAKKAQELNIKPLAVIRGYAAAGVDPAYMGLGPIPATRKALKKANLTVSDLGLIEANEAF
AAQALAVIKELELNPEITNVNGGAIALGHPIGASGARILVTLLHEMQKRNTKYGLATLCIGGGQGFALVVEKV

Sequences:

>Translated_393_residues
MEEVVIVSAVRTPIGSFLGSLAQTPAVDLGALVIKESLNRINLAPRFVDEVIMGNVLQAGLGQNPARQAAIKAGIPQEVP
AFTVNKVCGSGLKSVGLAYQAIATGDADIVVAGGMENMSLAPYVLPKARTGYRMGHDTLIDSMIKDGLWCAFTDVHMGIT
AENIAEKYNITREEQDKFALQSQERAIKAIDEGKFKEEIVPVIIPQKKGEPLVFSTDEFPKRGTSLEKLAALKPAFKKDG
TVTAGNASGINDGAAAVVVMSAKKAQELNIKPLAVIRGYAAAGVDPAYMGLGPIPATRKALKKANLTVSDLGLIEANEAF
AAQALAVIKELELNPEITNVNGGAIALGHPIGASGARILVTLLHEMQKRNTKYGLATLCIGGGQGFALVVEKV
>Mature_393_residues
MEEVVIVSAVRTPIGSFLGSLAQTPAVDLGALVIKESLNRINLAPRFVDEVIMGNVLQAGLGQNPARQAAIKAGIPQEVP
AFTVNKVCGSGLKSVGLAYQAIATGDADIVVAGGMENMSLAPYVLPKARTGYRMGHDTLIDSMIKDGLWCAFTDVHMGIT
AENIAEKYNITREEQDKFALQSQERAIKAIDEGKFKEEIVPVIIPQKKGEPLVFSTDEFPKRGTSLEKLAALKPAFKKDG
TVTAGNASGINDGAAAVVVMSAKKAQELNIKPLAVIRGYAAAGVDPAYMGLGPIPATRKALKKANLTVSDLGLIEANEAF
AAQALAVIKELELNPEITNVNGGAIALGHPIGASGARILVTLLHEMQKRNTKYGLATLCIGGGQGFALVVEKV

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=54.70737913486, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=47.3282442748092, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=46.4467005076142, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=43.5443037974684, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=34.2657342657343, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=33.7595907928389, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=63.7055837563452, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=59.4387755102041, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=46.6334164588529, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=44.5, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=36.2352941176471, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=48.3375959079284, Blast_Score=351, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=42.0918367346939, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=41.3705583756345, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=32.6340326340326, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=32.48730964467, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=47.3551637279597, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=36.8421052631579, Blast_Score=222, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=55.470737913486, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=48.2142857142857, Blast_Score=337, Evalue=7e-93,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=43.6868686868687, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=32.6291079812207, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41319; Mature: 41319

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEVVIVSAVRTPIGSFLGSLAQTPAVDLGALVIKESLNRINLAPRFVDEVIMGNVLQAG
CCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGQNPARQAAIKAGIPQEVPAFTVNKVCGSGLKSVGLAYQAIATGDADIVVAGGMENMSL
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHEEECCCCCEEEECCCCCCCC
APYVLPKARTGYRMGHDTLIDSMIKDGLWCAFTDVHMGITAENIAEKYNITREEQDKFAL
CCEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHH
QSQERAIKAIDEGKFKEEIVPVIIPQKKGEPLVFSTDEFPKRGTSLEKLAALKPAFKKDG
HHHHHHHHHHHCCCHHHCCCEEEEECCCCCCEEECCCCCCCCCCCHHHHHHHCCHHCCCC
TVTAGNASGINDGAAAVVVMSAKKAQELNIKPLAVIRGYAAAGVDPAYMGLGPIPATRKA
CEEECCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHCHHHCCCCHHHHCCCCCCHHHHH
LKKANLTVSDLGLIEANEAFAAQALAVIKELELNPEITNVNGGAIALGHPIGASGARILV
HHHCCCCHHHCCEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHEMQKRNTKYGLATLCIGGGQGFALVVEKV
HHHHHHHHCCCCCCEEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MEEVVIVSAVRTPIGSFLGSLAQTPAVDLGALVIKESLNRINLAPRFVDEVIMGNVLQAG
CCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGQNPARQAAIKAGIPQEVPAFTVNKVCGSGLKSVGLAYQAIATGDADIVVAGGMENMSL
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHEEECCCCCEEEECCCCCCCC
APYVLPKARTGYRMGHDTLIDSMIKDGLWCAFTDVHMGITAENIAEKYNITREEQDKFAL
CCEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHH
QSQERAIKAIDEGKFKEEIVPVIIPQKKGEPLVFSTDEFPKRGTSLEKLAALKPAFKKDG
HHHHHHHHHHHCCCHHHCCCEEEEECCCCCCEEECCCCCCCCCCCHHHHHHHCCHHCCCC
TVTAGNASGINDGAAAVVVMSAKKAQELNIKPLAVIRGYAAAGVDPAYMGLGPIPATRKA
CEEECCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHCHHHCCCCHHHHCCCCCCHHHHH
LKKANLTVSDLGLIEANEAFAAQALAVIKELELNPEITNVNGGAIALGHPIGASGARILV
HHHCCCCHHHCCEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHEMQKRNTKYGLATLCIGGGQGFALVVEKV
HHHHHHHHCCCCCCEEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]