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The map label for this gene is capA [H]

Identifier: 78044135

GI number: 78044135

Start: 661139

End: 662062

Strand: Direct

Name: capA [H]

Synonym: CHY_0750

Alternate gene names: 78044135

Gene position: 661139-662062 (Clockwise)

Preceding gene: 78043238

Following gene: 78043072

Centisome position: 27.53

GC content: 41.02

Gene sequence:

>924_bases
TTGCGCAGGGTAAAAATTATTTTTTTAACTTTTTTACTGGCAATTACCTTAACTAAAGCTTTTGCCAGTGCAGCTTCTCC
GGCAAAGGAAATTAAACTTGTCTTTTTGGGTGATGTCTTAGCCGGCGGCAACTTAAATTATTACTACCAAAAATACGGCT
ATGATTATCCCTGGCAGAAGGTTAAAAAGTATTTTCAGGGTAAGCTTGTTTTTGCCAATTTAGAAAGCTGTATTTCTCTT
CGGGGAAAGCCCGAAAGGAAAAAATACACTTTTCGGGGTCGACCGGAATTTTTAAAGGCTATGAAAAAGGCAGGAGTTAC
GGCGGTTTCGGTTGCAAATAACCACTCTGCGGATTATGGGCTGATAAGTCTTTATGATACCCTTGGCTACTTACGTCAAG
AAGGGATTTACTACTCAGGGGCAGGAAGGGATGTTTATATCACGGAAATCCCCTGGCAGGGATATAAAATTGGTTTTCTT
GCTTTTTCCCGGGTAATTCCTTCAACTGCCTGGGTGGCAAGCCCCAAAAAAACGGGAATCTGGTCTATTTATGAGCCGAA
TGTCGGTAAAATCTTAAAGTTAATCTGCGAAAATGATGCTAAATACGATCTTTTAGTGGTAAGCGTTCACTGGGGAGTGG
AGAGGGATTTAACCCCAAATCCACCTGAAATAAAACTTGCCCATAAACTGGTTGAAGCGGGAGCCGATGTGGTGATGGGC
CATCACCCGCATGTTGTGCAAAGGTATGAAATTTATAAAGGTAGACCAATCTTTTACAGCCTGGGTAACTTTATATTTAC
TTCCAGTGGTAATAAAGAAACTGCAAAAACTGTTATTGCTGAAGCGGTATTTACGGGAAGGAAACTAAAAAGTGTGGAGG
TTAGGCATGGAGAAATAAAAAGAGGCCAGCCGGTCATTAAATAA

Upstream 100 bases:

>100_bases
GGTTACGGGATATGACGAGCGGGGAAGGGTAAAAGCTGAAGATGGGGTAGTCTTGCAGGATAGGGGTTTCCAGCATTTTT
AATTATGAGGTGGAAGATAT

Downstream 100 bases:

>100_bases
TAATCCCCGGTTTTTACCGGGGATTTTTCCTCAATCTTTAAGTTTGCCAGCAAAATATGCTTCATACGCGGACAAGTCAA
AATAGCCGTGCCCGCTTAAA

Product: CapA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRRVKIIFLTFLLAITLTKAFASAASPAKEIKLVFLGDVLAGGNLNYYYQKYGYDYPWQKVKKYFQGKLVFANLESCISL
RGKPERKKYTFRGRPEFLKAMKKAGVTAVSVANNHSADYGLISLYDTLGYLRQEGIYYSGAGRDVYITEIPWQGYKIGFL
AFSRVIPSTAWVASPKKTGIWSIYEPNVGKILKLICENDAKYDLLVVSVHWGVERDLTPNPPEIKLAHKLVEAGADVVMG
HHPHVVQRYEIYKGRPIFYSLGNFIFTSSGNKETAKTVIAEAVFTGRKLKSVEVRHGEIKRGQPVIK

Sequences:

>Translated_307_residues
MRRVKIIFLTFLLAITLTKAFASAASPAKEIKLVFLGDVLAGGNLNYYYQKYGYDYPWQKVKKYFQGKLVFANLESCISL
RGKPERKKYTFRGRPEFLKAMKKAGVTAVSVANNHSADYGLISLYDTLGYLRQEGIYYSGAGRDVYITEIPWQGYKIGFL
AFSRVIPSTAWVASPKKTGIWSIYEPNVGKILKLICENDAKYDLLVVSVHWGVERDLTPNPPEIKLAHKLVEAGADVVMG
HHPHVVQRYEIYKGRPIFYSLGNFIFTSSGNKETAKTVIAEAVFTGRKLKSVEVRHGEIKRGQPVIK
>Mature_307_residues
MRRVKIIFLTFLLAITLTKAFASAASPAKEIKLVFLGDVLAGGNLNYYYQKYGYDYPWQKVKKYFQGKLVFANLESCISL
RGKPERKKYTFRGRPEFLKAMKKAGVTAVSVANNHSADYGLISLYDTLGYLRQEGIYYSGAGRDVYITEIPWQGYKIGFL
AFSRVIPSTAWVASPKKTGIWSIYEPNVGKILKLICENDAKYDLLVVSVHWGVERDLTPNPPEIKLAHKLVEAGADVVMG
HHPHVVQRYEIYKGRPIFYSLGNFIFTSSGNKETAKTVIAEAVFTGRKLKSVEVRHGEIKRGQPVIK

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 34615; Mature: 34615

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVKIIFLTFLLAITLTKAFASAASPAKEIKLVFLGDVLAGGNLNYYYQKYGYDYPWQK
CCEEEHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECEEECCCCCEEEHCCCCCCCHHH
VKKYFQGKLVFANLESCISLRGKPERKKYTFRGRPEFLKAMKKAGVTAVSVANNHSADYG
HHHHHCCCEEEEEHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCCC
LISLYDTLGYLRQEGIYYSGAGRDVYITEIPWQGYKIGFLAFSRVIPSTAWVASPKKTGI
HHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCEEEHHHHHHHHCCCCCEECCCCCCCE
WSIYEPNVGKILKLICENDAKYDLLVVSVHWGVERDLTPNPPEIKLAHKLVEAGADVVMG
EEEECCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEC
HHPHVVQRYEIYKGRPIFYSLGNFIFTSSGNKETAKTVIAEAVFTGRKLKSVEVRHGEIK
CCCCHHHHHHHHCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
RGQPVIK
CCCCCCC
>Mature Secondary Structure
MRRVKIIFLTFLLAITLTKAFASAASPAKEIKLVFLGDVLAGGNLNYYYQKYGYDYPWQK
CCEEEHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECEEECCCCCEEEHCCCCCCCHHH
VKKYFQGKLVFANLESCISLRGKPERKKYTFRGRPEFLKAMKKAGVTAVSVANNHSADYG
HHHHHCCCEEEEEHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCCC
LISLYDTLGYLRQEGIYYSGAGRDVYITEIPWQGYKIGFLAFSRVIPSTAWVASPKKTGI
HHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCEEEHHHHHHHHCCCCCEECCCCCCCE
WSIYEPNVGKILKLICENDAKYDLLVVSVHWGVERDLTPNPPEIKLAHKLVEAGADVVMG
EEEECCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEC
HHPHVVQRYEIYKGRPIFYSLGNFIFTSSGNKETAKTVIAEAVFTGRKLKSVEVRHGEIK
CCCCHHHHHHHHCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
RGQPVIK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]