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The map label for this gene is arsB [C]

Identifier: 78044124

GI number: 78044124

Start: 1803333

End: 1804610

Strand: Direct

Name: arsB [C]

Synonym: CHY_2019

Alternate gene names: 78044124

Gene position: 1803333-1804610 (Clockwise)

Preceding gene: 78043348

Following gene: 78042995

Centisome position: 75.09

GC content: 42.96

Gene sequence:

>1278_bases
ATGGGTCAATCGCTAATTGCCCTTACCATCTTTTTGGGGACCTATGCCTTAATTATTTCCGAAAAGCTTCACCGGGCCAT
TGCCGCACTTTTAGGCGGTACTTTATTAATTATTCTTGGAATTGTCTCTCAAGAAAAAGCAATCCACCACATCGACTGGA
ATACCCTGGGTCTCTTAATTGGCATGATGATTATTGTCGGCATTACCAAAAAAACAGGAGTCTTTCAGTACCTGGCGGTA
AAAGCGGTTAAATGGGCCAAAGGGGAGCCAGTTTATATTTTAATAGCTCTGGCTACCGTTACCGCCTTTTTATCGGCATT
TTTAGATAACGTTACAACAGTTTTACTGATTGTTCCGGTAACCTTCAATATAACTGACCGGCTGGGGATAAATCCTATTC
CCTTTCTTATTTCCCAGGTGTTAGCCAGTAACATCGGCGGTACCGCCACTTTAATCGGTGACCCGCCCAACATTATGATT
GGCAGCCAAACTCACTTGGACTTTTTAGATTTTCTTAAGAATTTAACTCCAGTCGTAGCAATAATCCATATTGCAACTAT
GTTTCTTTTTTATTTAATTTATCGTAAAGATTTTAATGTGTCAGCAGAATTAAAAAAGAAGTTACTTGATTTAAATGAAA
TTGACGAAATTAAAGATTTTGCCCTCTTAAAGAAAAGCCTTTTTGTCTTAGGCCTCGTCATTCTTGGCTTTATTTTGCAC
GGTACACTTGGTTTAGAATCGGCCACCATCGCCTTATTTGGTGCAGCGCTTTTATTAACCATCACCCGGGACGAGCCGGA
GGAAGTGCTTTTAACCGTGGAATGGCCTTCCATCTTTTTTTTCCTGGGTTTATTTATCGTGGTAGGAGGCCTTGTGGAAA
CGGGAGTTATCGACCGGGTAGCCCGCTGGAGCCTGGAAGCCACCAAAGGTAATTTCACTTTAACCGGGATGTTAATTCTC
TGGCTTTCGGCCATAGCTTCGGCATTTGTCGATAACATCCCCTTTGTGGCCACGATGATTCCGTTAATTCAGAAGATGGG
TGCTTTAGCCGGCATGACACCACAGGCTTTGGAGCCGCTGTGGTGGGCCTTATCTTTAGGCGCCTGCCTGGGCGGCAACG
GTACGATAATTGGCGCTTCAGCTAACGTGATTGTGGCGGGTTTAGCTGAGAAAAACGGCTATCCGATTTCGTTTATGGGT
TTTATGAAAATAGCCTTTCCTTTAATGCTGGTTTCGATAGTGATTTCCATGGGCTATCTTCTCCTGTTTTATTTTTAA

Upstream 100 bases:

>100_bases
GTTTTTAAATTATCAAACATTTACAAAGGGTTTATTATGTTTTAAGATGAATTTATGGTGACAATTACGGCTTGTGATTC
ACTAAAAGGGGGAGAAGGAA

Downstream 100 bases:

>100_bases
AACCATTTAAGCCGCGCTTTTGCGCGGCTTTTGTATTAAATTTGATACTTTTCTTTAATAAATGGTAAGATAAAAAATAA
AAAGCCCGGAGGTGTCTAAT

Product: arsenic transporter family protein

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MGQSLIALTIFLGTYALIISEKLHRAIAALLGGTLLIILGIVSQEKAIHHIDWNTLGLLIGMMIIVGITKKTGVFQYLAV
KAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPVTFNITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMI
GSQTHLDFLDFLKNLTPVVAIIHIATMFLFYLIYRKDFNVSAELKKKLLDLNEIDEIKDFALLKKSLFVLGLVILGFILH
GTLGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRVARWSLEATKGNFTLTGMLIL
WLSAIASAFVDNIPFVATMIPLIQKMGALAGMTPQALEPLWWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFMG
FMKIAFPLMLVSIVISMGYLLLFYF

Sequences:

>Translated_425_residues
MGQSLIALTIFLGTYALIISEKLHRAIAALLGGTLLIILGIVSQEKAIHHIDWNTLGLLIGMMIIVGITKKTGVFQYLAV
KAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPVTFNITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMI
GSQTHLDFLDFLKNLTPVVAIIHIATMFLFYLIYRKDFNVSAELKKKLLDLNEIDEIKDFALLKKSLFVLGLVILGFILH
GTLGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRVARWSLEATKGNFTLTGMLIL
WLSAIASAFVDNIPFVATMIPLIQKMGALAGMTPQALEPLWWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFMG
FMKIAFPLMLVSIVISMGYLLLFYF
>Mature_424_residues
GQSLIALTIFLGTYALIISEKLHRAIAALLGGTLLIILGIVSQEKAIHHIDWNTLGLLIGMMIIVGITKKTGVFQYLAVK
AVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPVTFNITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMIG
SQTHLDFLDFLKNLTPVVAIIHIATMFLFYLIYRKDFNVSAELKKKLLDLNEIDEIKDFALLKKSLFVLGLVILGFILHG
TLGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRVARWSLEATKGNFTLTGMLILW
LSAIASAFVDNIPFVATMIPLIQKMGALAGMTPQALEPLWWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFMGF
MKIAFPLMLVSIVISMGYLLLFYF

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=504, Percent_Identity=36.1111111111111, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI87082277, Length=305, Percent_Identity=25.9016393442623, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787039, Length=374, Percent_Identity=26.2032085561497, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581759, Length=501, Percent_Identity=35.3293413173653, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28574683, Length=501, Percent_Identity=35.3293413173653, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28574681, Length=501, Percent_Identity=35.3293413173653, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28574685, Length=501, Percent_Identity=35.3293413173653, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28574678, Length=501, Percent_Identity=35.3293413173653, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI19920704, Length=501, Percent_Identity=35.3293413173653, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI45550608, Length=487, Percent_Identity=35.1129363449692, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI221472711, Length=499, Percent_Identity=28.2565130260521, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24581764, Length=499, Percent_Identity=28.2565130260521, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI85724998, Length=484, Percent_Identity=30.1652892561983, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI62484377, Length=484, Percent_Identity=30.1652892561983, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24656008, Length=478, Percent_Identity=28.0334728033473, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 46012; Mature: 45881

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQSLIALTIFLGTYALIISEKLHRAIAALLGGTLLIILGIVSQEKAIHHIDWNTLGLLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCHHHHHHHH
GMMIIVGITKKTGVFQYLAVKAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPV
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEHEEEE
TFNITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMIGSQTHLDFLDFLKNLTPVVA
EEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHH
IIHIATMFLFYLIYRKDFNVSAELKKKLLDLNEIDEIKDFALLKKSLFVLGLVILGFILH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRV
HHCCCCHHHHHHHHHHHHEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ARWSLEATKGNFTLTGMLILWLSAIASAFVDNIPFVATMIPLIQKMGALAGMTPQALEPL
HHHHHEECCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
WWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFMGFMKIAFPLMLVSIVISMGYL
HHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLFYF
HHHCC
>Mature Secondary Structure 
GQSLIALTIFLGTYALIISEKLHRAIAALLGGTLLIILGIVSQEKAIHHIDWNTLGLLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCHHHHHHHH
GMMIIVGITKKTGVFQYLAVKAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPV
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEHEEEE
TFNITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMIGSQTHLDFLDFLKNLTPVVA
EEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHH
IIHIATMFLFYLIYRKDFNVSAELKKKLLDLNEIDEIKDFALLKKSLFVLGLVILGFILH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRV
HHCCCCHHHHHHHHHHHHEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ARWSLEATKGNFTLTGMLILWLSAIASAFVDNIPFVATMIPLIQKMGALAGMTPQALEPL
HHHHHEECCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
WWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFMGFMKIAFPLMLVSIVISMGYL
HHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLFYF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]