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The map label for this gene is cct1 [H]

Identifier: 78043200

GI number: 78043200

Start: 355739

End: 357304

Strand: Direct

Name: cct1 [H]

Synonym: CHY_0413

Alternate gene names: 78043200

Gene position: 355739-357304 (Clockwise)

Preceding gene: 78043787

Following gene: 78044836

Centisome position: 14.81

GC content: 46.3

Gene sequence:

>1566_bases
TTGAAAAAAGAAAACCAAACCCAGGAAATTGAAGAACGCTATCAGGCCCTTTTTTCCAATGCAGCAGCGGTAAAAGCCTT
AACCCAGGTGGTGGCCAATAGCTTGGGACCCAAGGGCCTGGATGCGATGTTGGTGGATAGATTTGGGGAAGTGGTGGTTA
CCAACGACGGAGTAACGATTTTGACTTTAATGGATGCCCAGCATCCGGCAGCCCGAATGGTCGTTAATATGGCCCGGGCT
CAGGAGAGGGAAGTGGGGGATGGTACTACTACGGCTGCAGTTTTAGCCGGAGCGCTGGTTTCTGAAGGAGTAAACCAGAT
TTTAAAAGGGGTTCCGGTTTCCAAAGTTTTAGCGGGAATGAACCGGGCGTTAAATCACGCTCTTTTCCTCATAAGAAAAA
ATGCGATTAAGGTAGGAAGTATTACCGACGACAGGCTATTGGCGGCGGCCAAAATTGCCGGACGGGGTGATGAAAGGGTT
GCTGCTATCCTGCGGGATGCGGCAGCAATGTTAGAAGATAAACTTCAAGATCCCGGGTTTAAATTAGCCGATTTGGTCTT
GGCAAAAGTTGGGGCCGATACTACGCTTATTCCGGGAGTGGTTATTAATAAGTCGCCCTTATGGGAGGAAGGATCGCAAA
AACTTCAGGAAGTTCGCCTTTTGGTTCTCGATGATGGTCTTTACCCCGAAGAAGTAGAAGAAGAAGCCCTTGCTTCCGAA
GCCGGATTTGAGCAGTATTTAAAAAACCAGAAAATATTTCAGGAAAATCTCAAAAAACTAAAAGAATTAGGGGTCAAGCT
AATCTTATTGACCCGGGGAATCAGCGATATTGCCGAAGAGTTTTGTTACGAAAATGAAATAATGGTTATAACCCGCATTA
CCCAGAAAGAATTAAAAAGGGTTTTAGAGTTTACCGGAGCCCGGGCGGCCAAAAGAACTTCTTTAAATAAGCCGGTAGAA
GAGTTGCAGAAAATGCTGGGTTATGCCCGAACCTGCTTTTATGATTCCCGGCTGGATTTTACCATTATTGAAGGAGGCGC
CGGAAAAGCTACCGCCACGGTTTTAATTGGAGCGGCTACCGATGAGGTGGTGGATGAACAGGAAAGAATTGCTAAAGATG
CGGCCGGAAGTTTTGCCGCCGCTTACCGCTCCGGGGTTTTGCCCGGAGGGGGAGCTTTCTTCCTCTACTTAAGCCGGGAA
GTGGAAAGCTTGAAAAATCGCTTGCCCGGTATGGAAAGCTACGGTGTTATGGCTTTTTCGGAAGCTCTTAAAGTTCCCTT
TCGGGTGATGGCGGAGAATGCCGGTTTTAACGGGCTGGAAAAGTTGGGGGACTTAATGACCCTGCAGGTCCAAAAAAATA
ACTACGCTTTGGGATTAGATTTTGAAACCGGTGAGTTTATCGATATGATAGCCGGCGGAGTGGTTGATCCTGCTGAAGTG
GTTTACCAGGCAGTAAAAAATGCCAGCGAGGTAGCTATTTCGTTATTGAAAATTAATACCATAATTAAAATGAAAGATTA
CGAAGTTTTAAAGGAAGGGGAGCAGGAAGATGGAGGAAAAAGATAA

Upstream 100 bases:

>100_bases
GCGTATGGAATACGCTAAAACCGTGGCGACGGTGGAGTTTTTAAGTAAGTACTTGTCGGAAATTATTGGTAATAAAAACT
TTTAACAGGAGGATTTAAGG

Downstream 100 bases:

>100_bases
AGAGGAAAAAGTAACCGGAGAAAATTTGGAACCGGAAGATAAAAATTTGGAACAGGAAGATAAAGAGGAGGTTGTCGGGC
CCCAGGAGGAACAACAAATT

Product: thermosome subunit alpha

Products: NA

Alternate protein names: Heat shock protein CCT1 [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MKKENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARA
QEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERV
AAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASE
AGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVE
ELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSRE
VESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEV
VYQAVKNASEVAISLLKINTIIKMKDYEVLKEGEQEDGGKR

Sequences:

>Translated_521_residues
MKKENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARA
QEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERV
AAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASE
AGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVE
ELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSRE
VESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEV
VYQAVKNASEVAISLLKINTIIKMKDYEVLKEGEQEDGGKR
>Mature_521_residues
MKKENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVNMARA
QEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERV
AAILRDAAAMLEDKLQDPGFKLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASE
AGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVE
ELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSRE
VESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEV
VYQAVKNASEVAISLLKINTIIKMKDYEVLKEGEQEDGGKR

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI24307939, Length=510, Percent_Identity=28.2352941176471, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI63162572, Length=526, Percent_Identity=26.2357414448669, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI57863257, Length=529, Percent_Identity=28.1663516068053, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI38455427, Length=526, Percent_Identity=26.8060836501901, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI5453607, Length=508, Percent_Identity=26.1811023622047, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI48762932, Length=516, Percent_Identity=27.3255813953488, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI58761484, Length=482, Percent_Identity=24.896265560166, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI261399877, Length=485, Percent_Identity=25.5670103092783, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI5453603, Length=526, Percent_Identity=26.615969581749, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI58331173, Length=517, Percent_Identity=24.3713733075435, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI4502643, Length=529, Percent_Identity=25.5198487712665, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI302058290, Length=509, Percent_Identity=23.7721021611002, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI261399875, Length=440, Percent_Identity=23.6363636363636, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI57863259, Length=284, Percent_Identity=28.5211267605634, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI302058292, Length=514, Percent_Identity=22.568093385214, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI58331185, Length=254, Percent_Identity=25.1968503937008, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI58331171, Length=526, Percent_Identity=23.574144486692, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI41399285, Length=148, Percent_Identity=31.7567567567568, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI31542947, Length=148, Percent_Identity=31.7567567567568, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=523, Percent_Identity=24.8565965583174, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25148561, Length=511, Percent_Identity=25.6360078277886, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25144674, Length=519, Percent_Identity=27.5529865125241, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17532601, Length=525, Percent_Identity=27.2380952380952, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17532603, Length=510, Percent_Identity=26.2745098039216, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17564182, Length=521, Percent_Identity=26.4875239923225, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71998178, Length=541, Percent_Identity=25.1386321626617, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI25147750, Length=528, Percent_Identity=26.7045454545455, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144678, Length=533, Percent_Identity=24.202626641651, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32566944, Length=443, Percent_Identity=26.410835214447, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555558, Length=526, Percent_Identity=25.4752851711027, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144680, Length=426, Percent_Identity=22.3004694835681, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71981457, Length=326, Percent_Identity=23.9263803680982, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193210679, Length=139, Percent_Identity=32.3741007194245, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322446, Length=526, Percent_Identity=26.2357414448669, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320418, Length=547, Percent_Identity=27.0566727605119, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322524, Length=525, Percent_Identity=28.1904761904762, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322350, Length=526, Percent_Identity=27.5665399239544, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320393, Length=539, Percent_Identity=25.417439703154, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6320058, Length=533, Percent_Identity=25.140712945591, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322452, Length=532, Percent_Identity=24.0601503759398, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322049, Length=531, Percent_Identity=24.2937853107345, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323288, Length=531, Percent_Identity=26.7419962335217, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24649027, Length=517, Percent_Identity=28.2398452611219, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24649029, Length=517, Percent_Identity=28.2398452611219, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24583944, Length=517, Percent_Identity=26.4990328820116, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17647245, Length=508, Percent_Identity=26.7716535433071, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24652903, Length=506, Percent_Identity=26.6798418972332, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19921848, Length=523, Percent_Identity=26.7686424474187, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24647512, Length=528, Percent_Identity=26.7045454545455, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24647510, Length=528, Percent_Identity=26.7045454545455, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24645179, Length=512, Percent_Identity=24.0234375, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI18858175, Length=531, Percent_Identity=26.3653483992467, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28571140, Length=531, Percent_Identity=26.3653483992467, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859933, Length=533, Percent_Identity=24.953095684803, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=25.1908396946565, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=25.1908396946565, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=25.1908396946565, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=26.9961977186312, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=26.9961977186312, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56627; Mature: 56627

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCEEE
LTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGM
EEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
NRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGF
HHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
KLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASE
HHHHHHHHHHCCCCEECCCEEECCCCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHH
AGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKR
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHHH
VLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAAT
HHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEECCH
DEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFS
HHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCHHHHH
EALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEV
HHHHCCHHHHHCCCCCCHHHHHCCEEEEEEECCCEEEEEECCCCHHHHHHHCCCCCHHHH
VYQAVKNASEVAISLLKINTIIKMKDYEVLKEGEQEDGGKR
HHHHHHCHHHHHHHHHHHHHHHEECCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKKENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCEEE
LTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGM
EEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
NRALNHALFLIRKNAIKVGSITDDRLLAAAKIAGRGDERVAAILRDAAAMLEDKLQDPGF
HHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
KLADLVLAKVGADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASE
HHHHHHHHHHCCCCEECCCEEECCCCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHH
AGFEQYLKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKELKR
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHHH
VLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGGAGKATATVLIGAAT
HHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEECCH
DEVVDEQERIAKDAAGSFAAAYRSGVLPGGGAFFLYLSREVESLKNRLPGMESYGVMAFS
HHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCHHHHH
EALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEV
HHHHCCHHHHHCCCCCCHHHHHCCEEEEEEECCCEEEEEECCCCHHHHHHHCCCCCHHHH
VYQAVKNASEVAISLLKINTIIKMKDYEVLKEGEQEDGGKR
HHHHHHCHHHHHHHHHHHHHHHEECCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9335278 [H]