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The map label for this gene is fnr [H]

Identifier: 78043177

GI number: 78043177

Start: 338526

End: 339167

Strand: Direct

Name: fnr [H]

Synonym: CHY_0394

Alternate gene names: 78043177

Gene position: 338526-339167 (Clockwise)

Preceding gene: 78044545

Following gene: 78044875

Centisome position: 14.1

GC content: 44.08

Gene sequence:

>642_bases
ATGGAAAACTGGGAGGTTTTAAAAAAGATACCCCTTTTCGGGGAGCTTTCCCCGGATGATTTAAAGGAAATCGGGAATCT
TCTTTATTCCCGCCGGCTGAAAAAAGGACAAATTTTGTTTTCCGAAGGGGACCCGGGGGCGGCAGTATACTTTTTAAAAA
GCGGGCGGATTAAGCTCTATAAAGAGGACCGGGAAGGCCGGGAACACATCCTTCATTATGTTGAACCGGGAGATATTTTT
GCCGAAGTGGTGCTATTTTCCAAGCGTCCTTATCCTGCCACCGCCGAGGTTATAGAGCCGGGGGAAGTCCTGGTAATTCC
CAACGAGGAAATGGAGAACCTCTTGAAAAAACGCGGAGAAATTGCGTTAAATCTCATCAAGGTGCTGTTGTATCGTTTAG
ATTTAGCCAATCAAAAAATTAAAGAGTTAGCGTTAAAAGATAGTTTAGCCCGGGTATGTAGCGTTCTCTTACGCTACGGC
CCGGTAATTAATCTTTCCCAGCAGGAAATAGCCAATTTAGCCGGGGTTTCCCGGGAAACGGCCAGTCGAATAATAAATGA
GTTTAAACGTTTAGGAGTACTTCGGGCCGAAGGGCGGAGCTTAGAAATTATAAATTATGACAAATTAAAAGATTTCTCTT
AA

Upstream 100 bases:

>100_bases
TAAATACGCCGAAAATAAAAGAATTGACCGCCGATAAAAAAATTATTAAAGTTATTATAGTACCGGAAAAATTAATTAAT
ATTGTGGTAGCGGGGTAACA

Downstream 100 bases:

>100_bases
ATACTTTTTTCACAAAAAAGGAATTGGGCGAGTTTAAGCGAACTTTGTTTAATAGAAAAAGTTAATACCCCACTCTACGG
GTGCCCGGAAGGGTTAAAAG

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MENWEVLKKIPLFGELSPDDLKEIGNLLYSRRLKKGQILFSEGDPGAAVYFLKSGRIKLYKEDREGREHILHYVEPGDIF
AEVVLFSKRPYPATAEVIEPGEVLVIPNEEMENLLKKRGEIALNLIKVLLYRLDLANQKIKELALKDSLARVCSVLLRYG
PVINLSQQEIANLAGVSRETASRIINEFKRLGVLRAEGRSLEIINYDKLKDFS

Sequences:

>Translated_213_residues
MENWEVLKKIPLFGELSPDDLKEIGNLLYSRRLKKGQILFSEGDPGAAVYFLKSGRIKLYKEDREGREHILHYVEPGDIF
AEVVLFSKRPYPATAEVIEPGEVLVIPNEEMENLLKKRGEIALNLIKVLLYRLDLANQKIKELALKDSLARVCSVLLRYG
PVINLSQQEIANLAGVSRETASRIINEFKRLGVLRAEGRSLEIINYDKLKDFS
>Mature_213_residues
MENWEVLKKIPLFGELSPDDLKEIGNLLYSRRLKKGQILFSEGDPGAAVYFLKSGRIKLYKEDREGREHILHYVEPGDIF
AEVVLFSKRPYPATAEVIEPGEVLVIPNEEMENLLKKRGEIALNLIKVLLYRLDLANQKIKELALKDSLARVCSVLLRYG
PVINLSQQEIANLAGVSRETASRIINEFKRLGVLRAEGRSLEIINYDKLKDFS

Specific function: It is involved in the activation of genes necessary for anaerobic respiration [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=175, Percent_Identity=26.2857142857143, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1787595, Length=211, Percent_Identity=24.1706161137441, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24266; Mature: 24266

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENWEVLKKIPLFGELSPDDLKEIGNLLYSRRLKKGQILFSEGDPGAAVYFLKSGRIKLY
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCEEEE
KEDREGREHILHYVEPGDIFAEVVLFSKRPYPATAEVIEPGEVLVIPNEEMENLLKKRGE
ECCCCCHHHHEECCCCHHHHHHHHHHCCCCCCCCHHEECCCCEEEECCHHHHHHHHHHHH
IALNLIKVLLYRLDLANQKIKELALKDSLARVCSVLLRYGPVINLSQQEIANLAGVSRET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHH
ASRIINEFKRLGVLRAEGRSLEIINYDKLKDFS
HHHHHHHHHHCCCEECCCCEEEEEEHHCCCCCC
>Mature Secondary Structure
MENWEVLKKIPLFGELSPDDLKEIGNLLYSRRLKKGQILFSEGDPGAAVYFLKSGRIKLY
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCEEEE
KEDREGREHILHYVEPGDIFAEVVLFSKRPYPATAEVIEPGEVLVIPNEEMENLLKKRGE
ECCCCCHHHHEECCCCHHHHHHHHHHCCCCCCCCHHEECCCCEEEECCHHHHHHHHHHHH
IALNLIKVLLYRLDLANQKIKELALKDSLARVCSVLLRYGPVINLSQQEIANLAGVSRET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHH
ASRIINEFKRLGVLRAEGRSLEIINYDKLKDFS
HHHHHHHHHHCCCEECCCCEEEEEEHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8846791; 9384377 [H]