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The map label for this gene is thlA [H]

Identifier: 78042981

GI number: 78042981

Start: 1145592

End: 1146773

Strand: Direct

Name: thlA [H]

Synonym: CHY_1288

Alternate gene names: 78042981

Gene position: 1145592-1146773 (Clockwise)

Preceding gene: 78043724

Following gene: 78044634

Centisome position: 47.7

GC content: 44.5

Gene sequence:

>1182_bases
ATGCAGGAGGTAGTAATTTTAAGTGCGGTGAGGACTGCTATAGGCAAATTCGGAGGTAGCTTAAAAGACATTCCTGCTGC
AGAATTGGGGGCTATCGTTATAAAAGAAGCTTTGGTGAGAGCTCAAATACCACCTGCAGAGGTAGATGAAGTTATTTTTG
GGAATGTCTTACAAGCTGGACAAGGGCAAAATCCAGCGCGTCAGGCGGCTATTAAGGCAGGCATTCCGGTAGATATTCCG
GCAATGACTGTAAATATGGTTTGTGGCTCCGGTTTACGGTCTGTCAGTTTAGCAGCTACTCTTATTGCTGCAGGGGAAGC
TGATCTTATTGTCGCAGGCGGGATGGAAAATATGTCTGCTGCTCCCTATGCCATACCCGGAGCACGTTGGGGTACACGCA
TGGGGGATGGAAAGATTGTTGATTTGATGATTAAGGATGGTCTATGGGATGCTTTTTATGACTACCATATGGGGATTACT
GCTGAAAATTTGGCAGAACGCTATAATATAAGCCGGGAAGAACAAGACAGATTTGCTTTAGAAAGTCAACGGCGAGCTGA
AAAAGCAATTAAAGAAGGACGTTTCCGTGATGAGATTGTTCCGGTGAAGTTACCTCAGCGGAAAGGAGAACCTCTTGAAT
TTGTTCAAGATGAGAACCCGCGTTTTGATACTACTCTTGAAGCGTTAGCAAAGTTAAAGCCAGCATTTAAAGAAGGTGGA
ACAGTAACTGCCGGCAATGCATCAAGCATAAATGACGGTGCTGCGGCATTGGTAATAGCTTCCAGCAAAAAAGCTGAGAG
TTTGGGAATTAAACCAATGGCTGTTATTCGGAGTTGGGGAGCTACCGGGGTAGATCCAAGTATTATGGGGATCGGTCCTG
TTGGAGCTACTCGTAAAGCGTTAAAGAGAGCAGGCTTAACAATTGCTGATATAGATTTAGTAGAAGCTAATGAAGCTTTT
GCAGCTCAAGCCCTTGCAGTAGCTAAGGAGTTAGAACTTGACTTAAGTAAAACTAATGTAAATGGTGGTGCTATTGCTTT
AGGTCACCCGATTGGTGCAAGCGGGGCAAGAATTCTTGTAACTTTGCTTCATGAGATGAAAAAATCAAATAGCCGCTATG
GCCTGGCTACGTTGTGCATTGGTGGCGGTATGGGAGTAGCAGCTATAGTAGAAAAAGCTTAG

Upstream 100 bases:

>100_bases
GAGTAATTTAAAGGGGGGTAGATCATTAAATTGAAAACTTAAAATTAGAATTAAGTTGCTTCTATTAGCTGTATTTAAAG
TTGAGAGGAGGAGGCTTACT

Downstream 100 bases:

>100_bases
ATGAACATTGATTCTTAGGGTGAATTATGATGAAAAAATCAATAAATGCAATTGTTATTAATGAAAATGATAATGTGGCT
ACGGTTATTGAGGATATAAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MQEVVILSAVRTAIGKFGGSLKDIPAAELGAIVIKEALVRAQIPPAEVDEVIFGNVLQAGQGQNPARQAAIKAGIPVDIP
AMTVNMVCGSGLRSVSLAATLIAAGEADLIVAGGMENMSAAPYAIPGARWGTRMGDGKIVDLMIKDGLWDAFYDYHMGIT
AENLAERYNISREEQDRFALESQRRAEKAIKEGRFRDEIVPVKLPQRKGEPLEFVQDENPRFDTTLEALAKLKPAFKEGG
TVTAGNASSINDGAAALVIASSKKAESLGIKPMAVIRSWGATGVDPSIMGIGPVGATRKALKRAGLTIADIDLVEANEAF
AAQALAVAKELELDLSKTNVNGGAIALGHPIGASGARILVTLLHEMKKSNSRYGLATLCIGGGMGVAAIVEKA

Sequences:

>Translated_393_residues
MQEVVILSAVRTAIGKFGGSLKDIPAAELGAIVIKEALVRAQIPPAEVDEVIFGNVLQAGQGQNPARQAAIKAGIPVDIP
AMTVNMVCGSGLRSVSLAATLIAAGEADLIVAGGMENMSAAPYAIPGARWGTRMGDGKIVDLMIKDGLWDAFYDYHMGIT
AENLAERYNISREEQDRFALESQRRAEKAIKEGRFRDEIVPVKLPQRKGEPLEFVQDENPRFDTTLEALAKLKPAFKEGG
TVTAGNASSINDGAAALVIASSKKAESLGIKPMAVIRSWGATGVDPSIMGIGPVGATRKALKRAGLTIADIDLVEANEAF
AAQALAVAKELELDLSKTNVNGGAIALGHPIGASGARILVTLLHEMKKSNSRYGLATLCIGGGMGVAAIVEKA
>Mature_393_residues
MQEVVILSAVRTAIGKFGGSLKDIPAAELGAIVIKEALVRAQIPPAEVDEVIFGNVLQAGQGQNPARQAAIKAGIPVDIP
AMTVNMVCGSGLRSVSLAATLIAAGEADLIVAGGMENMSAAPYAIPGARWGTRMGDGKIVDLMIKDGLWDAFYDYHMGIT
AENLAERYNISREEQDRFALESQRRAEKAIKEGRFRDEIVPVKLPQRKGEPLEFVQDENPRFDTTLEALAKLKPAFKEGG
TVTAGNASSINDGAAALVIASSKKAESLGIKPMAVIRSWGATGVDPSIMGIGPVGATRKALKRAGLTIADIDLVEANEAF
AAQALAVAKELELDLSKTNVNGGAIALGHPIGASGARILVTLLHEMKKSNSRYGLATLCIGGGMGVAAIVEKA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=52.9411764705882, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=46.969696969697, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=45.5470737913486, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=45.0632911392405, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=36.150234741784, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI194353979, Length=250, Percent_Identity=37.6, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=57.1428571428571, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.8142493638677, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=47.5, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=43, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=33.9024390243902, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=48.2051282051282, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=37.8516624040921, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=40.3553299492386, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=34.2723004694836, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=31.2182741116751, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=45.7286432160804, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=40.5541561712846, Blast_Score=254, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=53.8265306122449, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=46.4102564102564, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=44.5012787723785, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=33.5680751173709, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41117; Mature: 41117

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEVVILSAVRTAIGKFGGSLKDIPAAELGAIVIKEALVRAQIPPAEVDEVIFGNVLQAG
CCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
QGQNPARQAAIKAGIPVDIPAMTVNMVCGSGLRSVSLAATLIAAGEADLIVAGGMENMSA
CCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCC
APYAIPGARWGTRMGDGKIVDLMIKDGLWDAFYDYHMGITAENLAERYNISREEQDRFAL
CCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHH
ESQRRAEKAIKEGRFRDEIVPVKLPQRKGEPLEFVQDENPRFDTTLEALAKLKPAFKEGG
HHHHHHHHHHHCCCCCCCEECEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHCHHHHCCC
TVTAGNASSINDGAAALVIASSKKAESLGIKPMAVIRSWGATGVDPSIMGIGPVGATRKA
EEECCCCCCCCCCCEEEEEECCCCHHHCCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHH
LKRAGLTIADIDLVEANEAFAAQALAVAKELELDLSKTNVNGGAIALGHPIGASGARILV
HHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCHHHHHH
TLLHEMKKSNSRYGLATLCIGGGMGVAAIVEKA
HHHHHHHHCCCCCCEEEEEECCCCCHHHHEECC
>Mature Secondary Structure
MQEVVILSAVRTAIGKFGGSLKDIPAAELGAIVIKEALVRAQIPPAEVDEVIFGNVLQAG
CCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
QGQNPARQAAIKAGIPVDIPAMTVNMVCGSGLRSVSLAATLIAAGEADLIVAGGMENMSA
CCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCC
APYAIPGARWGTRMGDGKIVDLMIKDGLWDAFYDYHMGITAENLAERYNISREEQDRFAL
CCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHH
ESQRRAEKAIKEGRFRDEIVPVKLPQRKGEPLEFVQDENPRFDTTLEALAKLKPAFKEGG
HHHHHHHHHHHCCCCCCCEECEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHCHHHHCCC
TVTAGNASSINDGAAALVIASSKKAESLGIKPMAVIRSWGATGVDPSIMGIGPVGATRKA
EEECCCCCCCCCCCEEEEEECCCCHHHCCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHH
LKRAGLTIADIDLVEANEAFAAQALAVAKELELDLSKTNVNGGAIALGHPIGASGARILV
HHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCHHHHHH
TLLHEMKKSNSRYGLATLCIGGGMGVAAIVEKA
HHHHHHHHCCCCCCEEEEEECCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]